Potassium ion chemical ionization and other uses of an alkali thermionic emitter in mass spectrometry

Bombick, D.D.; Pinkston, J. David; Allison, John

doi:10.1021/ac00267a022

Cited by 53 publications

(16 citation statements)

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“…Several research groups have actively attempted to detect many organic complexes by attaching alkali metal ions to the sample molecules; 8,9 however, all these experiments have generally been employed to investigate the chemical ionization reac-tions rather than to provide a complementary tool to identify the chemical species. No special attempt has been made so far to increase the instrumental sensitivity, and currently, no alkali metal ion attachment mass spectrometer is available commercially as a complete instrument.…”

Section: Introductionmentioning

confidence: 99%

Lithium ion attachment mass spectrometry: Instrumentation and features

Selvin

Fujii

2001

Review of Scientific Instruments

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Articles you may be interested inTransportable real-time single-particle ion trap mass spectrometer Rev. Sci. Instrum. 76, 064102 (2005); 10.1063/1.1938607 Corona discharge ion mobility spectrometry at reduced pressures Rev. Sci. Instrum. 75, 4656 (2004); 10.1063/1.1809301 Ion preparation systems for atomic isobar reduction in accelerator mass spectrometry AIP Conf. Development of an electrostatic ion guide in chemical ionization mass spectrometry Rev. Sci. Instrum. 69, 4002 (1998); 10.1063/1.1149223Fourier transform ion cyclotron resonance mass spectrometry AIP Conf.The design and construction of a lithium ion attachment mass spectrometer that is used to study the occurrence of free radical intermediates and molecular and atomic species ͑which are not found under ordinary conditions͒ on a real-time basis in the gas phase are described. The newly developed device exhibits several advantages over conventional mass spectrometers. The performance of this equipment was extensively tested and optimized, and experimental tests show that the efficiency and sensitivity of the instrument are moderately high. The main applications and possible future perspectives of this approach are briefly reviewed.

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Section: Introductionmentioning

confidence: 99%

Lithium ion attachment mass spectrometry: Instrumentation and features

Selvin

Fujii

2001

Review of Scientific Instruments

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“…Ions, such as Na + , leave the sur face and combine in the gas phase with desorbed neu tral molecules via ion-dipole interactions [9,14], Several interesting studies have also been done on IR and thermal desorption of neutrals using postionization techniques. Allison et al [15] and Röllgen et al [16] showed that the emitted neutrals could be ionized in the gas phase by using an intersecting Reprint requests to Dr. J. Grotemeyer, Institut für Physi kalische und Theoretische Chemie, Technische Universität München, Lichtenbergstraße 4, D-8046 Garching, BRD.…”

Section: Introductionmentioning

confidence: 99%

Infrared Desorption of Neutral Molecules Embedded in Transparent Matrices

Beavis

Lindner

Grotemeyer

et al. 1988

Zeitschrift Für Naturforschung A

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I n f r a r e d D e s o r p tio n o f N e u t r a l M o le c u le s E m b e d d e d in T r a n s p a r e n t M a tr ic e s R.C. Beavis, J. Lindner, J. Grotemeyer, and E.W. Schlag Institut für Physikalische und Theoretische Chemie, Technische Universität München Z. Naturforsch. 43a, 1083Naturforsch. 43a, -1090Naturforsch. 43a, (1988; received July 25, 1988 The desorption of intact molecules by pulsed IR irradiation is shown to depend on the IR absorption of the matrix. IR transparent matrices, such as NaCl or NH4N03, increase the total yield and the shot-to-shot stability of the sample. IR absorbing matrices decrease the yield of intact molecules and increase the amount of pyrolysis products.Using semi-transparent sugar matrices with dipeptide samples, the most intense fragment, i.e. the parent molecule having lost 18 u, is suppressed. This fragment is formed by pyrolysis during IR desorption. Three other prominent fragments are caused by the UV photoionization step.The experimental results suggest that a model involving bulk stresses and strain may be necessary to explain the observations.

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“…Since the 1,2-elimination mechanism is inconsistent with the experimental results for peptides, alternative degradation mechanisms were considered. Since Hshifts are frequently involved in the thermal degradation of peptides, as well as other thermally labile molecules [3,15], determining the source of the shifting H is key to determining the mechanism. This can be done using deuterium labeling.…”

Section: The Primary Thermal Degradation Processes Of Peptidesmentioning

confidence: 99%

“…In this article, we present K+ ionization of desorbed species (K+IDS) for the characterization of the primary thermal degradation chemistry of peptides. K + IDS is a desorption/ionization technique for mass spectrometry that was introduced in 1984 [3]. It is based on the use of rapid heating of an analyte to produce, in the gas phase, intact analyte molecules and thermal degradation products.…”

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confidence: 99%

Characterization of the primary thermal degradation processes of peptides using the mass spectrometric technique K⁺IDS, K⁺ ionization of desorbed species

Allison

1994

J. Am. Soc. Mass Spectrom.

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The mass spectrometric technique of K(+) ionization of desorbed species, K(+)IDS, is used here to characterize the primary thermal degradation chemistry of small peptides. In this technique, a small amount of a compound is rapidly heated in the condensed phase. Desorption of the intact molecule can occur. Also, thermal degradation products are formed which quickly desorb as well, rather than remain on the surface and undergo subsequent chemistry. The desorbed molecules form adducts with gas phase K(+) ions, and a mass spectrum is obtained. Deuterium labeling experiments, and the use of derivatizing reagents, allows for the thermal degradation chemistry of small peptides to be elucidated. Apparently, skeletal bond cleavages are accompanied by H-shifts, although the hydrogen atoms shift from "remote" sites, brought into close proximity with the fragmenting skeletal bond via secondary interactions. Experimental results are presented that allow for correlations between thermal degradation chemistry and the resulting K(+)IDS mass spectra to be made.

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Potassium ion chemical ionization and other uses of an alkali thermionic emitter in mass spectrometry

Cited by 53 publications

References 20 publications

Lithium ion attachment mass spectrometry: Instrumentation and features

Lithium ion attachment mass spectrometry: Instrumentation and features

Infrared Desorption of Neutral Molecules Embedded in Transparent Matrices

Characterization of the primary thermal degradation processes of peptides using the mass spectrometric technique K⁺IDS, K⁺ ionization of desorbed species

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Potassium ion chemical ionization and other uses of an alkali thermionic emitter in mass spectrometry

Cited by 53 publications

References 20 publications

Lithium ion attachment mass spectrometry: Instrumentation and features

Lithium ion attachment mass spectrometry: Instrumentation and features

Infrared Desorption of Neutral Molecules Embedded in Transparent Matrices

Characterization of the primary thermal degradation processes of peptides using the mass spectrometric technique K+IDS, K+ ionization of desorbed species

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Product

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Characterization of the primary thermal degradation processes of peptides using the mass spectrometric technique K⁺IDS, K⁺ ionization of desorbed species