Potassium homeostasis during disease progression of Alzheimer’s Disease
Evgeniia Samokhina,
Armaan Mangat,
Chandra S. Malladi
et al.
Abstract:Alzheimers disease (AD) is an age-dependent neurodegenerative disorder characterized by neuronal loss leading to dementia and ultimately death. Whilst the loss of neurons is central to the disease, it is becoming clear that glia, specifically astrocytes, contribute to the onset and progression of neurodegeneration. Astrocytic role in retaining ion homeostasis in the extracellular milieu is fundamental for multiple brain functions, including synaptic plasticity and neuronal excitability, which are compromised d… Show more
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