Potassium bromate in bread, health risks to bread consumers and toxicity symptoms amongst bakers in Bamenda, North West Region of Cameroon

Ncheuveu, Nkwatoh Therese; Fon, Tayebatu  Percline; Navti, Lifoter Kenneth

doi:10.1016/j.heliyon.2023.e13146

Cited by 6 publications

(4 citation statements)

References 25 publications

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“…Potassium bromate (PB) has been widely used as a food additive and a processing and maturing agent at the industrial level. It has been used in many consumer items such as beverages, cosmetics, food packaging, mouth hygiene products, and pharmaceuticals since its discovery in 1900 [ 1 , 2 ]. During processing with the compound in these industries, traces of it get into the living system.…”

Section: Introductionmentioning

confidence: 99%

Zinc Oxide Nanoparticles Blunt Potassium-Bromate-Induced Renal Toxicity by Reinforcing the Redox System

et al. 2023

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Potassium bromate (PB) is a general food additive, a significant by-product during water disinfection, and a carcinogen (Class II B). The compound emits toxicity depending on the extent of its exposure and dose through consumable items. The current study targeted disclosing the ameliorative efficacy of zinc oxide nanoparticles (ZnO NPs) prepared by green technology in PB-exposed Swiss albino rats. The rats were separated into six treatment groups: control without any treatment (Group I), PB alone (Group II), ZnO alone (Group III), ZnO NP alone (Group IV), PB + ZnO (Group V), and PB + ZnO NPs (Group VI). The blood and kidney samples were retrieved from the animals after following the treatment plan and kept at −20 °C until further analysis. Contrary to the control (Group I), PB-treated rats (Group II) exhibited a prominent trend in alteration in the established kidney function markers and disturbed redox status. Further, the analysis of the tissue and nuclear DNA also reinforced the biochemical results of the same treatment group. Hitherto, Groups III and IV also showed moderate toxic insults. However, Group VI showed a significant improvement from the PB-induced toxic insults compared to Group II. Hence, the present study revealed the significant therapeutic potential of the NPs against PB-induced nephrotoxicity in vivo, pleading for their usage in medicines having nephrotoxicity as a side effect or in enhancing the safety of the industrial use of PB.

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Section: Introductionmentioning

confidence: 99%

Zinc Oxide Nanoparticles Blunt Potassium-Bromate-Induced Renal Toxicity by Reinforcing the Redox System

et al. 2023

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“…Metal‐catalysed oxidation of pea protein increased the aggregation stability of the droplets during emulsification, and the structural interface of pea protein milk was more uniform (Hinderink et al ., 2020). Potassium bromate is used as an oxidant for bread making, which has a positive effect on bread, such as increasing its volume, improving air chamber structure and retaining carbon dioxide (Shanmugavel et al ., 2020; Ncheuveu Nkwatoh et al ., 2023). In addition, protein oxidation is often thought to be related to lipid oxidation, and lipid oxidation products could accelerate protein oxidation in food (Ahmad et al ., 2023; Najamuddin et al ., 2023).…”

Section: Introductionmentioning

confidence: 99%

Protein oxidation‐induced changes in the physicochemical properties and quality of plant food

Wu,

Ji,

Xue

et al. 2024

Int J of Food Sci Tech

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SummaryProtein oxidation is widely present in food systems and is susceptible to internal factors involving lipids and enzymes as well as external factors such as temperature and oxygen promoters. Protein oxidation leads to modification of the peptide skeletons and amino acid side chains, which in turn alters the structural characteristics of proteins, including protein cleavage, aggregation and derivative formation, and severely affects their physicochemical properties and bioavailability, thereby reducing the edible and storage qualities of foods. This review summarises the main factors that cause and regulate oxidation of plant protein, the effects of protein oxidation on food quality and strategies to ameliorate protein over‐oxidation, aiming to provide meaningful information for the development of high‐quality plant protein products.

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“…Multiple organ damage including liver, kidney, and the central nervous system have been reported. It has also been shown that KBrO3 is carcinogenic in human and experimental animals (Kurokawa et al, 1990;Ncheuveu et al, 2023). In view of these toxic effects, many countries including Canada, Nigeria, and India have banned the use of potassium bromate as food additive.…”

Section: Introductionmentioning

confidence: 99%

Administration of combined exogenous L-arginine and ascorbic acid attenuates potassium bromate-induced renal and hepatic toxicity

Kolawole,

Bakare,

Ayankunle

et al. 2024

njpr

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Background: The use of potassium bromate (KBrO3) as food additive is still widespread and there is need to search for agents with protective effect against KBrO3-induced toxicity. Objective: In this study, the protective effects of L-arginine, ascorbic acid, and their combined regimen on KBrO3-induced renal and hepatic toxicity were investigated in Wistar rats. Methods: Five groups of male rats were used for the study. Group A was given distilled water (control), and group B was treated with KBrO3 only. In addition to KBrO3, groups C, D, and E were given L-arginine, ascorbic acid, and combined L-arginine and ascorbic acid respectively. After 28-day treatment, blood samples were taken for biochemical analysis; liver and kidney were harvested for histological examination. Results: KBrO3 significantly (p < 0.05) raised serum levels of creatinine, urea, ALT, and AST compared to distilled water-treated control. Levels of SOD, CAT, and GPx were also significantly reduced. No significant changes in these parameters were observed with ascorbic acid and L-arginine given separately. Treatment with combined regimen of L-arginine and ascorbic acid resulted in significant (p < 0.05) reduction in the serum levels of creatinine, AST and ALT, and significant increase in the serum levels of SOD, CAT and GPx compared to the control. The distortions induced by KBrO3 in the structural architecture of renal and hepatic tissues were largely reduced in rats treated with combined ascorbic acid and L-arginine. Conclusion: The study showed that L-arginine and ascorbic acid synergistically attenuate KBrO3-induced renal and hepatic toxicity.

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Potassium bromate in bread, health risks to bread consumers and toxicity symptoms amongst bakers in Bamenda, North West Region of Cameroon

Cited by 6 publications

References 25 publications

Zinc Oxide Nanoparticles Blunt Potassium-Bromate-Induced Renal Toxicity by Reinforcing the Redox System

Zinc Oxide Nanoparticles Blunt Potassium-Bromate-Induced Renal Toxicity by Reinforcing the Redox System

Protein oxidation‐induced changes in the physicochemical properties and quality of plant food

Administration of combined exogenous L-arginine and ascorbic acid attenuates potassium bromate-induced renal and hepatic toxicity

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