Posture of Healthy Subjects Modulated by Transcutaneous Spinal Cord Stimulation

Shamantseva, Natalia; Timofeeva, Olga; Gvozdeva, Alisa; Andreeva, Irina; Moshonkina, Tatiana

doi:10.3390/life13091909

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…The electrodes were placed on the skin -cathodes over the spinal motor centers, at the level of C3-C5, T11-T12 or L1-L2 vertebrae, and anodes over the iliac crests or clavicles [1]. Many studies with healthy subjects have shown that tSCS modulates spinal neuronal networks, manifested by changes in locomotion and posture [14][15][16][17].…”

Section: Transcutaneous Spinal Cord Stimulationmentioning

confidence: 99%

Non-Invasive Spinal Cord Stimulation for Motor Rehabilitation of Patients with Spinal Muscular Atrophy Treated with Orphan Drugs

Moshonkina,

Novikov,

Maldova

et al. 2024

Preprint

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Spinal muscular atrophy (SMA) is an orphan disease characterized by progressive degeneration of spinal alpha motor neurons. In recent years, nusinersen and several other drugs have been approved for the treatment of this disease. Transcutaneous spinal cord stimulation (tSCS) modulates spinal neuronal networks, resulting in changes in locomotion and posture in patients with severe spinal cord injury and stroke. We hypothesize that tSCS can activate motor neurons that are intact and restored by medication, slow the decline in motor activity, and contribute to the development of motor skills in SMA patients. Thirty-seven children and adults with SMA types 2 and 3 participated in the study. The median duration of drug treatment was over 20 months. Application of tSCS was performed during physical therapy for 20-40 minutes per day for ~12 days. Outcome measures were specific SMA motor scales, goniometry of contractured joints, forced vital capacity. Significant increases in motor function, improved respiratory function, and decreased contracture were observed in both types 2 and 3 SMA participants. The magnitude of functional changes was not associated with participants age. Further studies are needed to elucidate the reasons for the beneficial effects of spinal cord electrical stimulation in SMA.

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Section: Transcutaneous Spinal Cord Stimulationmentioning

confidence: 99%

Non-Invasive Spinal Cord Stimulation for Motor Rehabilitation of Patients with Spinal Muscular Atrophy Treated with Orphan Drugs

Moshonkina,

Novikov,

Maldova

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Subsequent studies have validated this concept. Many studies with healthy subjects have shown that tSCS modulates spinal neuronal networks, manifested by changes in locomotion and posture [ 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Non-Invasive Spinal Cord Stimulation for Motor Rehabilitation of Patients with Spinal Muscular Atrophy Treated with Orphan Drugs

Novikov,

Maldova,

Shamantseva

et al. 2024

Biomedicines

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Spinal muscular atrophy (SMA) is an orphan disease characterized by the progressive degeneration of spinal alpha motor neurons. In recent years, nusinersen and several other drugs have been approved for the treatment of this disease. Transcutaneous spinal cord stimulation (tSCS) modulates spinal neuronal networks, resulting in changes in locomotion and posture in patients with severe spinal cord injury and stroke. We hypothesize that tSCS can activate motor neurons that are intact and restored by medication, slow the decline in motor activity, and contribute to the development of motor skills in SMA patients. Thirty-seven children and adults with SMA types 2 and 3 participated in this study. The median duration of drug treatment was over 20 months. The application of tSCS was performed during physical therapy for 20–40 min per day for ~12 days. Outcome measures were specific SMA motor scales, goniometry of contractured joints, and forced vital capacity. Significant increases in motor function, improved respiratory function, and decreased contracture were observed in both type 2 and 3 SMA participants. The magnitude of functional changes was not associated with participant age. Further studies are needed to elucidate the reasons for the beneficial effects of spinal cord electrical stimulation on SMA.

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Transcutaneous spinal cord stimulation modulates quiet standing in healthy adults: stimulation site and cognitive style matter

Shamantseva,

Timofeeva,

Semenova

et al. 2024

Front. Neurosci.

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The study explored the effects of transcutaneous electrical spinal cord stimulation (tES) on postural control. Subjects were divided into field-dependent (FD) and field-independent (FI) groups according to their cognitive style. FD subjects use an exteroceptive afferent stream for spatial orientation, while FI subjects use an interoceptive stream. In darkness, vertical posture is maintained by head-trunk stabilization in FD subjects and by independent movements of body segments in FI subjects. Previously, we showed that tES at the L1-L2 vertebral level decreased postural stability in FD subjects. Now, stimulation was applied at the T11-T12 vertebral level (midline, above the left or right dorsal roots). Quiet standing was assessed using stabilometry in 18 FD and FI participants. Participants stood on a force platform in soundproof chamber with eyes closed during tES. Midline and left tES significantly improved postural stability by up to 28% in FD participants, while posture did not change significantly in FI participants. Pronounced differences between the effects of T11-T12 and L1-L2 stimulation are associated with selective topographical activation of proximal and distal leg muscles during tES of the lumbar enlargement. This study highlights the importance of considering cognitive style in postural control research.

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Posture of Healthy Subjects Modulated by Transcutaneous Spinal Cord Stimulation

Cited by 3 publications

References 31 publications

Non-Invasive Spinal Cord Stimulation for Motor Rehabilitation of Patients with Spinal Muscular Atrophy Treated with Orphan Drugs

Non-Invasive Spinal Cord Stimulation for Motor Rehabilitation of Patients with Spinal Muscular Atrophy Treated with Orphan Drugs

Non-Invasive Spinal Cord Stimulation for Motor Rehabilitation of Patients with Spinal Muscular Atrophy Treated with Orphan Drugs

Transcutaneous spinal cord stimulation modulates quiet standing in healthy adults: stimulation site and cognitive style matter

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