Postural Tachycardia Syndrome

Grubb, Blair P.; Karabin, Beverly

doi:10.1161/circulationaha.107.761650

Cited by 42 publications

(52 citation statements)

References 1 publication

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“…In a recent discussion of POTS, 39 Grubb divided patients with POTS into 2 physiological groups on the basis of the redistribution of blood volume 40 or a hyperadrenergic state of uncertain origin. 41,42 Contributions may also arise from changes in hematocrit and in blood viscosity.…”

Section: Why Are “Positive” Tilt Test Results Similar (Early On) In Fmentioning

confidence: 99%

Postural Tachycardia Syndrome and Reflex Syncope: Similarities and Differences

Stewart

2009

The Journal of Pediatrics

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Section: Why Are “Positive” Tilt Test Results Similar (Early On) In Fmentioning

confidence: 99%

Postural Tachycardia Syndrome and Reflex Syncope: Similarities and Differences

Stewart

2009

The Journal of Pediatrics

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“…It is not associated with chronic debilitating conditions such as prolonged bed rest or the use of medications known to diminish vascular or autonomic tone. [1] The syndrome is an abnormal physiological state that is commonly due to an inability of the peripheral vasculature to maintain adequate resistance in the face of orthostatic stress resulting in excessive pooling of blood in the more dependent areas of the body. [2–4] This functional decline in circulatory volume will elicit a compensatory increase in heart rate and myocardial contractility.…”

Section: Introductionmentioning

confidence: 99%

Postural orthostatic tachycardia syndrome is associated with platelet storage pool deficiency

Gunning¹,

Karabin

Blomquist³

et al. 2016

Medicine

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Mechanisms have been postulated to explain postural orthostatic tachycardia syndrome (POTS), however, the etiology of this often debilitating disorder remains unknown. We conducted a retrospective case–control study of 181 POTS patients who exhibited/reported bleeding symptoms for a specific platelet (PL) dysfunction disorder, delta granule storage pool deficiency (δ-SPD).Patients were included only if results of blood tests for δ-SPD were available. Electron microscopy was utilized to diagnose δ-SPD. An ELISA assay was used to determine serotonin (5HT) concentration in PLs and medical record review was employed to collect patients’ clinical symptoms.The most common bleeding symptom was easy bruising (71%) but frequent nose bleeds, heavy menstrual bleeding, and a family history of bleeding were also commonly reported. Of the patients studied, 81% were diagnosed with δ-SPD. Our investigation of 5HT concentration extracted from PLs revealed significantly lower levels of 5HT in POTS patients when compared to that of control subjects. Our data suggest that patients with POTS have significant comorbidities including bleeding symptoms and/or family bleeding histories, and have diminished PL 5HT levels supporting the hypothesis that POTS is a low 5HT level disorder. While we describe a significant relationship with POTS and δ-SPD, this finding does not constitute an etiology for POTS.Our results establish an additional comorbidity frequently seen in POTS that could explain a number of disparate symptoms often affecting the severity of POTS.

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“…Grubb and Karabin [15] indicate that the symptoms of POTS can result from the inability to maintain constriction of the blood vessels in the lower body while in an upright position. Grubb [1] further defines the symptoms as palpitations, fatigue, lightheadedness, exercise intolerance, diminished concentration, and presyncope, which greatly impact normal functioning.…”

Section: Clinical Diagnosismentioning

confidence: 99%

“…While there are many symptoms identified in POTS patients, the diagnostics revolve around the key symptom, palpitations, which occur with an upright posture [7,13,15,29,30,31,41,42,43]. Much of the literature is focused on measuring the scale changes in heart rate and blood pressure, using the Valsalva maneuver [13,29,30] or HUTT [7,13,14,29,30,31,41,42,43].…”

Section: Synthesis Of the Literaturementioning

confidence: 99%

Postural Orthostatic Tachycardia Syndrome (POTS): Assess, Diagnose, and Evaluate for POTS Treatment (ADEPT)

Schmidt¹,

Karabin

Malone

2017

Integr Med Int

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Background/Aims: Postural orthostatic tachycardia syndrome (POTS) is often identified as being clinically underdiagnosed and undertreated, resulting in unnecessary costs and poorer patient outcomes. Method: Through a literature search, the information has been synthesized, supporting the creation of a POTS diagnostic screening tool that can be implemented within the psychiatric outpatient clinic. Results: POTS patients are often referred to psychiatry for the treatment of chronic fatigue and anxiety disorders. Psychiatric professionals are in a position to prescreen for POTS in patients with orthostatic intolerance. Conclusion: A diagnostic prescreening tool helps to identify patients with POTS so they can be referred for proper treatment, improving their functionality and quality of life, and decreasing the healthcare burden.

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Postural Tachycardia Syndrome

Cited by 42 publications

References 1 publication

Postural Tachycardia Syndrome and Reflex Syncope: Similarities and Differences

Postural Tachycardia Syndrome and Reflex Syncope: Similarities and Differences

Postural orthostatic tachycardia syndrome is associated with platelet storage pool deficiency

Postural Orthostatic Tachycardia Syndrome (POTS): Assess, Diagnose, and Evaluate for POTS Treatment (ADEPT)

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