Postural instability as a measure of sedative drug response.

1. Blood pressure regulation was studied in 12 healthy elderly subjects after double‐blind randomised administration of placebo, 15 mg and 30 mg temazepam at 10.00 h and 22.00 h. 2. Supine and standing heart rate and blood pressure were measured after daytime administration and supine measurements were obtained during sleep. 3. Temazepam caused a fall in systolic blood pressure and an increase in heart rate after morning administration. These changes were greater in the standing position and were dose‐dependent; for standing blood pressure and heart rate 1 h after administration there was a 7 mm Hg fall and 6 beats min‐ 1 increase after 15 mg temazepam and a 10 mm Hg fall and 8 beats min‐1 increase after 30 mg temazepam. Temazepam magnified the fall in systolic blood pressure and increase in heart rate that occurred with standing. Temazepam enhanced the fall in systolic blood pressure that occurred during sleep (mean +/‐ s.d.; placebo: ‐23 +/‐ 10 mm Hg, 15 mg temazepam: ‐31 +/‐ 13 mm Hg, 30 mg temazepam: ‐36 +/‐ 14 mm Hg). 4. These changes in blood pressure regulation caused by temazepam may have clinical importance in some elderly individuals.

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“…Adverse effects on postural balance reflexes and cognition are well described (Evans & Jarvis, 1973;Swift, 1984 …”

Section: Resultsmentioning

confidence: 99%

Effect of temazepam on blood pressure regulation in healthy elderly subjects.

Ford

Hoffman

Blaschke

1990

Brit J Clinical Pharma

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“…The most notable result of this study was how little effect quite high doses of alcohol had on the psychomotor tests used. This cannot be attributed to a general lack of sensitivity of the tests, since previous studies have shown that they are easily capable of detecting the effects of moderate doses of other central depressant drugs (Hindmarch, 1979;Scott, Fagan and Tiplady, 1982;Fagan, Scott and Tiplady, 1984;Swift, 1984). Figure 5 shows a composite graph of results of body sway, measured in our laboratory, after the highest ethanol dose compared with results associated with normal clinical doses of amitriptyline, temazepam, chlormethiazole and zimelidine.…”

Section: Resultsmentioning

confidence: 99%

Effects of Ethanol on Psychomotor Performance

Fagan

Tiplady²,

Scott

1987

British Journal of Anaesthesia

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“…we were unable to demonstrate any effect with oxazepam alone might be explained by the doseresponse relationship, the oxazepam dose being too small (Swift et al, 1984 …”

Section: Kinetic Studymentioning

confidence: 58%

Single dose pharmacokinetics and pharmacodynamics of oral oxazepam during concomitant administration of propranolol and labetalol.

Sonne

Døssing

Loft

et al. 1990

Brit J Clinical Pharma

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1 The oral kinetics of oxazepam after a single 15 mg oral dose was investigated in six healthy volunteers before and during concomitant administration of the ,-adrenoceptor antagonists propranolol (80 mg) and labetalol (200 mg) (racemates). 2 A possible pharmacodynamic interaction between oxazepam and the 13-adrenoceptor antagonists was examined using a simple reaction time test (SRT) and by measurement of postural sway. 3 The kinetics of oxazepam were not affected significantly by propranolol or labetalol, although oxazepam and labetalol share the glucuronidation pathway.4 The SRT was increased by combination of both 0-adrenoceptor antagonists with oxazepam, with the greatest increase after the coadministration of oxazepam with propranolol. Administration of the P-adrenoceptor antagonists alone had no significant effect. 5 Postural sway was affected significantly only by the combination of oxazepam and propranolol.

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Postural instability as a measure of sedative drug response.

Abstract: 1 Methods of varying complexity have been devised to measure movements involved in the control of posture (sway). 2 Dose-related effects of centrally acting drugs on postural sway have been demonstrated.

Cited by 45 publications

References 17 publications

Effect of temazepam on blood pressure regulation in healthy elderly subjects.

Effect of temazepam on blood pressure regulation in healthy elderly subjects.

Effects of Ethanol on Psychomotor Performance

Single dose pharmacokinetics and pharmacodynamics of oral oxazepam during concomitant administration of propranolol and labetalol.

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