Posttreatment prognosis of patients with esthesioneuroblastoma

Abstract

A biopsy should always be obtained in cases suspected of EN because histology is a strong prognostic indicator and will help guide appropriate treatment. Unimodal surgery and combined surgery/radiotherapy appear to be of equivalent efficacy with respect to survival in patients with EN. Chemotherapy should be considered in high-grade EN.

Long-Term Outcome of Esthesioneuroblastoma: Hyams Grade Predicts Patient Survival

“…6 These findings have been confirmed in a large meta-analysis published in 2010 by Kane et al 4 Further, Kane et al found, as previously published by our institution, that higher grade pathology (by Hyams criteria) may predict poorer prognosis. 4,7 This finding, however, has not been confirmed by a direct retrospective or prospectively conducted trial in a similar manner. Further, some institutions as recently as 2006 advocated no pathologic interpretation beyond confirming ENB and therefore do not report a Hyams grade, since it is believed ENB grade is of no prognostic significance.…”

“…12 This series is unique in that over 75% of the ENB presented as Kadish C or D, which is substantially higher than most reported series, which typically report 50% or less. 4,9,12,15 We agree with Dulguerov et al that the current staging systems lack distinction specifically within the Kadish C cohort, such as distinguishing dural transgression; however, due to low numbers, even within this series it is difficult to firmly differentiate this subset of tumors. 2,12 However, it may be useful to divide Kadish C lesion postoperatively by whether or not negative margins could be achieved, or whether it is simply unresectable.…”

“…The median age was 50, with a range of 12 to 91 years. 4 There was no evidence of a bimodal distribution, as has been described in the literature. A slight male predominance is frequently reported and is the case in this series (56% male).…”

Genetic and molecular alterations in olfactory neuroblastoma: implications for pathogenesis, prognosis and treatment

“…Other studies showed usefulness of adjuvant chemotherapy, especially in Kadish stage C high grade ONB [9]. Cisplatin-based chemotherapy, usually with etoposide, is an accepted mode of treatment in advanced, recurrent, especially high grade cases [10–13], but also non-platinum schemes (irinotecan, docetaxel, doxorubicin, ifosfamide, vincristine) were described to be effective [14]. Currently no studies are available showing correlation of expression of certain proteins regarding the response to chemotherapy.…”

Atypical Olfactory Neuroblastoma Presenting as Sinonasal Polyposis with Nasopharyngeal Extension: A Case Report

“…Chemotherapy can be used in an adjuvant or neoadjuvant attempt and also in the metastatic phase or recurrent or advanced disease, although its effectiveness has still not been established. Such multimodality therapy has become the most common approach to esthesioneuroblastoma [13] [14].…”