Posttraumatic Vasospasm Detected by Continuous Brain Tissue Oxygen Monitoring: Treatment with Intraarterial Verapamil and Balloon Angioplasty

Shahlaie, Kiarash; Boggan, James E.; Latchaw, Richard E.; Cheng, Jin; Muizelaar, J. Paul

doi:10.1007/s12028-008-9138-z

Cited by 29 publications

(13 citation statements)

References 90 publications

(150 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cerebral vasoconstriction underlies numerous pathologic conditions, including cerebral vasospasm, ischemia after aneurysmal subarachnoid hemorrhage (Jordan and Nyquist, 2010), the reversible cerebral vasoconstriction syndrome associated with nonaneurysmal subarachnoid hemorrhage, pregnancy, or exposure to certain drugs (Sattar et al, 2010), posttraumatic cerebral vasospasm after traumatic brain injury (Shahlaie et al, 2009), and abrupt-onset severe headaches (Ju and Schwedt, 2010). In addition, cerebral vasoconstriction and hypertension may coexist (Sekine et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Cerebrovascular Dilation via Selective Targeting of the Cholane Steroid-Recognition Site in the BK Channel β1-Subunit by a Novel Nonsteroidal Agent

et al. 2013

View full text Add to dashboard Cite

The Ca 21 /voltage-gated K 1 large conductance (BK) channel b1 subunit is particularly abundant in vascular smooth muscle. By determining their phenotype, BK b1 allows the BK channels to reduce myogenic tone, facilitating vasodilation. The endogenous steroid lithocholic acid (LCA) dilates cerebral arteries via BK channel activation, which requires recognition by a BK b1 site that includes Thr169. Whether exogenous nonsteroidal agents can access this site to selectively activate b1-containing BK channels and evoke vasodilation remain unknown. We performed a chemical structure database similarity search using LCA as a template, along with a two-step reaction to generate sodium 3-hydroxyolean-12-en-30-oate (HENA). HENA activated the BK (cbv1 1 b1) channels cloned from rat cerebral artery myocytes with a potency (EC 50 5 53 mM) similar to and an efficacy (Â2.5 potentiation) significantly greater than that of LCA.This HENA action was replicated on native channels in rat cerebral artery myocytes. HENA failed to activate the channels made of cbv1 1 b2, b3, b4, or b1T169A, indicating that this drug selectively targets b1-containing BK channels via the BK b1 steroid-sensing site. HENA (3-45 mM) dilated the rat and C57BL/ 6 mouse pressurized cerebral arteries. Consistent with the electrophysiologic results, this effect was larger than that of LCA. HENA failed to dilate the arteries from the KCNMB1 knockout mouse, underscoring BK b1's role in HENA action. Finally, carotid artery-infusion of HENA (45 mM) dilated the pial cerebral arterioles via selective BK-channel targeting. In conclusion, we have identified for the first time a nonsteroidal agent that selectively activates b1-containing BK channels by targeting the steroid-sensing site in BK b1, rendering vasodilation.

show abstract

Section: Introductionmentioning

confidence: 99%

Cerebrovascular Dilation via Selective Targeting of the Cholane Steroid-Recognition Site in the BK Channel β1-Subunit by a Novel Nonsteroidal Agent

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Meanwhile exclusive traumatic subarachnoid hemorrhage patients' studies showed no difference in either mortality or poor outcome between placebo and Calcium Channel blockers groups (18). Repeated radiological or Trans Cranial Doppler (TCD) plus consequential serial clinical non invasive continuous monitoring in deteriorating patients may guide decision making as regards treatment effectiveness especially in the dilemma of absent evidence based evaluation (15).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Traumatic Subarachnoid Hemorrhage in Developed and Developing Communities

El-Fiki¹,

El-Ghandour²

2015

World Neurosurgery

View full text Add to dashboard Cite

“…[25]. Один из потенциальных ме-ханизмов снижения PbtO 2 , несмотря на нормальные величины ВЧД и ЦПД, пос-ттравматический вазоспазм, ведущий фактор вторичной травмы, его отмеча-ют у 20-50% пациентов [31][32][33].…”

Section: рисunclassified

Monitoring and treatment of severe traumatic brain injury

Кардаш¹,

Cherniy²,

Gorodnik³

et al. 2014

Ukr Neurosurg J

View full text Add to dashboard Cite

Posttraumatic Vasospasm Detected by Continuous Brain Tissue Oxygen Monitoring: Treatment with Intraarterial Verapamil and Balloon Angioplasty

Abstract: Posttraumatic vasospasm should be included in the differential diagnosis of cerebral hypoxia (e.g., low P(bt)O(2)) following TBI. Management strategies for PTV may include early, aggressive intraarterial therapies including drug infusion and balloon angioplasty.

Cited by 29 publications

References 90 publications

Cerebrovascular Dilation via Selective Targeting of the Cholane Steroid-Recognition Site in the BK Channel β1-Subunit by a Novel Nonsteroidal Agent

Cerebrovascular Dilation via Selective Targeting of the Cholane Steroid-Recognition Site in the BK Channel β1-Subunit by a Novel Nonsteroidal Agent

Traumatic Subarachnoid Hemorrhage in Developed and Developing Communities

Monitoring and treatment of severe traumatic brain injury

Contact Info

Product

Resources

About