Posttraumatic Stress Symptoms, Quality of Life, and Stress Burden in Caregivers of Patients With Severe Mental Illness: An Underestimated Health Concern

Rady, Ahmed; Mouloukheya, T.; Gamal, Eman

doi:10.3389/fpsyt.2021.623499

Cited by 11 publications

(13 citation statements)

References 50 publications

(27 reference statements)

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“…Furthermore, the prevalence of probable PTSD in this study (12.1%) exceeded the general lifetime prevalence of PTSD (worldwide between 1.3 and 8.8%; ( 31 )) and in the Netherlands (7.4%; ( 30 )). These findings are in line with previous research which showed that a severe or chronic illness of a relative can be experienced as a traumatic stressor and has been associated with manifestations of PTSD symptomatology ( 32 – 34 ). In addition, as hypothesized, family members who reported PWS-related trauma scored higher on PTSD symptoms than participants who experienced a different, non PWS-related traumatic event.…”

Section: Discussionsupporting

confidence: 93%

Family Matters: Trauma and Quality of Life in Family Members of Individuals With Prader-Willi Syndrome

et al. 2022

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BackgroundPrader-Willi syndrome (PWS) is a potentially life threatening, genetic developmental disorder that requires lifelong medical treatment and behavioral management. PWS has a major impact on the patient's social environment. In this study, we have explored traumatic life events and symptoms of posttraumatic stress disorder (PTSD) in family members of individuals with PWS. We have also assessed quality of life in relation to trauma manifestations. In addition, we have evaluated demographic characteristics such as living setting of PWS patients as well as PWS symptom severity.MethodsData of this observational study were obtained by means of the Life Events Checklist DMS-5, the Posttraumatic Stress Disorder Checklist DSM-5, the abbreviated World Health Organization Quality of Life questionnaire, the Lancashire Quality of Life Profile questionnaire, and a short demographic inventory. The study sample includes 98 adults aged 19 to 80 years (M = 49, SD = 15), who are relatives of 69 individuals with PWS aged 0 to 58 years (M = 19, SD = 13). Participants were recruited via the two Dutch patient associations PWS and the Dutch Digital Center of Expertise PWS.ResultsLife time prevalence of traumatic events (93%) was higher in family members of PWS patients (“PWS relatives”) than in the general Dutch population (81%). Of those who reported any traumatic event, almost half reported PWS-related events. The prevalence of probable PTSD was higher in PWS relatives (12.1%) than the general lifetime prevalence of PTSD (worldwide, and in the Netherlands 7.4%). Predominant trauma symptoms in PWS relatives were “negative changes in arousal and reactivity” and “negative changes in cognition and mood;” both significantly negatively related to quality of life. Symptom severity of PWS individuals, as well as the associated trauma symptom severity of their relatives increased with age of the PWS individual. The presence of trauma symptoms was less frequent among relatives of PWS individuals living in a care facility.ConclusionsHaving a relative with PWS is associated with higher prevalence of traumatic experiences and greater vulnerability to PTSD. Raising awareness in health care professionals of trauma symptoms in PWS relatives may contribute to effective treatment of their psychosocial stress. In addition, timely interventions might prevent family members from developing psychopathology like PTSD.

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Section: Discussionsupporting

confidence: 93%

Family Matters: Trauma and Quality of Life in Family Members of Individuals With Prader-Willi Syndrome

et al. 2022

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“…A total of 5034 caregivers from 23 countries were included in the analysis. Six studies were conducted in Nigeria [ 18 , 40 , 41 , 42 , 43 , 44 ], five studies in Brazil [ 45 , 46 , 47 , 48 , 49 ], three studies each in Nepal [ 50 , 51 , 52 ] and Turkey [ 53 , 54 , 55 ], two studies each in Hong Kong [ 56 , 57 ], the USA [ 58 , 59 ], and Taiwan [ 60 , 61 ], and one study each in Africa [ 62 ], China [ 63 ], Chile [ 64 ], Egypt [ 65 ], Greece [ 66 ], India [ 67 ], Ireland [ 68 ], Italy [ 69 ], Japan [ 70 ], Jordan [ 71 ], Kuwait [ 72 ], Poland [ 73 ], Portugal [ 74 ], Singapore [ 75 ], Spain [ 76 ], and the Netherlands [ 77 ]. In terms of study setting, 11 studies were conducted in the community, 18 studies in the hospital, and nine studies in the clinic (refer to Table S2 ).…”

Section: Resultsmentioning

confidence: 99%

“… Pooled prevalence of caregiver burden among caregivers of patients with mental illness [ 18 , 40 , 41 , 44 , 48 , 49 , 50 , 51 , 52 , 54 , 55 , 56 , 58 , 59 , 60 , 62 , 63 , 64 , 65 , 68 , 69 , 70 , 71 , 72 , 75 , 77 ]. …”

Section: Figurementioning

confidence: 99%

“… Subgroup forest plot on the study setting (Community: [ 50 , 58 , 64 , 68 , 69 , 70 , 75 , 77 ]; Clinic: [ 40 , 49 , 54 , 56 , 59 , 71 ]; Hospital: [ 18 , 41 , 44 , 48 , 51 , 52 , 55 , 60 , 62 , 63 , 65 , 72 ]). …”

Section: Figurementioning

confidence: 99%

“… Subgroup forest plot on the types of measurement used (Zarit: [ 44 , 50 , 51 , 52 , 55 , 56 , 58 , 60 , 63 , 71 , 72 , 75 , 77 ]; Others: [ 6 , 18 , 40 , 41 , 48 , 49 , 54 , 62 , 64 , 65 , 68 , 69 , 70 ]). …”

Section: Figurementioning

confidence: 99%

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Caregiver Burden among Caregivers of Patients with Mental Illness: A Systematic Review and Meta-Analysis

et al. 2022

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Due to the increasing importance of caregivers in the treatment outcomes of patients with mental illness, this study aimed to systematically review studies investigating the former’s caregiver burden and determine its prevalence. An open search, without filters, was conducted. Articles were selected from Medline, Scopus, and PubMed from inception to 30 April 2022 using the PRISMA protocol. Subgroup analyses examined the between-group differences by study setting, measurements used, and disorder type. A total of 5034 caregivers from 23 countries were included in this review. Thirty-nine studies were included in the systematic review, and, among them, twenty-six were deemed eligible for meta-analysis. The overall pooled prevalence of caregiver burden among caregivers of individuals with mental illness was 31.67% (95% CI = 26.22–37.12). Pooled prevalence was the highest among care recipients receiving treatment in a hospital setting (36.06%; 95%CI = 22.50–49.63), followed by the community and clinic settings. Caregiver prevalence values were higher for burden measured using the Zarit Burden Interview (38.05%; 95%CI = 27.68–48.43). compared with other instruments, and for carers of care recipients with psychosis (35.88%; 95%CI = 27.03–44.72) compared with those without. Thus, targeted interventions should focus on caregivers of patients in hospital settings and with psychotic symptoms.

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Comparison Between Burden of Care Partners of Individuals with Alzheimer’s Disease Versus Individuals with Other Chronic Diseases

2023

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Background: Caregiving in Alzheimer's disease (AD) is often provided by informal care partners, who spend more hours per week on average than care partners of individuals with conditions other than AD. However, the burden of care in partners of individuals with AD has not been systematically compared to that of other chronic diseases. Objective: The current study therefore aims to compare the care partner burden of AD to that of other chronic diseases through a systematic literature review. Methods: Data was collected from journal articles published in the last 10 years, using two unique search strings in PubMed and analysed using pre-defined patient-reported outcome measures (PROMs) including the EQ-5D-5L, GAD-7, GHQ-12, PHQ-9, WPAI and the ZBI. The data was grouped according to the included PROMs and the diseases studied. The number of participants in the studies reporting burden of caregiving in AD was adjusted to reflect the number of participants in studies reporting care partner burden in other chronic diseases. Results: All results in this study are reported as a mean value and standard deviation (SD). The ZBI measurement was the most frequently used PROM to collect care partner burden (15 studies) and showed a moderate burden (mean 36.80, SD 18.35) on care partners of individuals with AD, higher than most of the other included diseases except for those characterized by psychiatric symptoms (mean scores 55. 92 and 59.11). Other PROMs such as PHQ-9 (six studies) and GHQ-12 (four studies) showed a greater burden on care partners of individuals with other chronic diseases such as heart failure, haematopoietic cell transplantations, cancer and depression compared to AD. Likewise, GAD-7 and EQ-5D-5L measurements showed a lesser burden on care partners of individuals with AD compared to care partners of individuals with anxiety, cancer, asthma and chronic obstructive pulmonary disease. The current study suggests that care partners of individuals with AD experience a moderate burden, but M. Demirbas (&)

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Posttraumatic Stress Symptoms, Quality of Life, and Stress Burden in Caregivers of Patients With Severe Mental Illness: An Underestimated Health Concern

Cited by 11 publications

References 50 publications

Family Matters: Trauma and Quality of Life in Family Members of Individuals With Prader-Willi Syndrome

Family Matters: Trauma and Quality of Life in Family Members of Individuals With Prader-Willi Syndrome

Caregiver Burden among Caregivers of Patients with Mental Illness: A Systematic Review and Meta-Analysis

Comparison Between Burden of Care Partners of Individuals with Alzheimer’s Disease Versus Individuals with Other Chronic Diseases

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