Posttraumatic stress disorder symptomatology in the course of allogeneic HSCT: a prospective study

Esser, Peter; Kuba, Katharina; Scherwath, Angela; Schirmer, Lena; Schulz-Kindermann, Frank; Dinkel, Andreas; Balck, Friedrich; Koch, Uwe; Kröger, Nicolaus; Götze, Heide; Mehnert, Anja

doi:10.1007/s11764-016-0579-7

Cited by 30 publications

(24 citation statements)

References 29 publications

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“…39 In a sample of hematopoietic cell transplant survivors, 15% met criteria for PTSD over a period from pre-transplant to one year post. 40 Survivors who were younger, diagnosed with later stage disease and recent completion of cancer treatment were at risk for PTSD. 38 Pain was associated with higher PTSD levels as well as being female.…”

Section: Anxiety and Depression In Different Populations Of Survivorsmentioning

confidence: 99%

Anxiety and Depression in Cancer Survivors

Syrjala

2017

Medical Clinics of North America

243

146

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Synopsis Most cancer survivors adjust well to life after cancer but some experience persisting negative mood such as cancer-related fears, post-traumatic stress, anxiety, or depression. Mood fluctuations may not reach criteria for a clinical diagnosis but sub-clinical symptoms can interfere with quality of life. Females, and adolescents and young adults are particularly at risk for mood disturbances. Behavioral interventions such as cognitive behavioral therapy and pharmacological treatments can effectively treat these distressing emotions. Much of the research on managing emotional needs after cancer has been completed with breast cancer survivors and more work is needed with diverse groups of survivors.

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Section: Anxiety and Depression In Different Populations Of Survivorsmentioning

confidence: 99%

Anxiety and Depression in Cancer Survivors

Syrjala

2017

Medical Clinics of North America

243

146

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“…These estimates of PTSD symptomatology are consistent with other studies in HCT recipients. 4 A smaller yet meaningful number of patients (i.e., 5% to 28%) meet criteria for clinically-significant PTSD symptomatology (hereafter referred to as PTSD). 3–8 Interestingly, rates of PTSD appear to be relatively consistent independent of time since transplant, suggesting that PTSD may be chronic in some patients.…”

Section: Introductionmentioning

confidence: 99%

“…3–8 Interestingly, rates of PTSD appear to be relatively consistent independent of time since transplant, suggesting that PTSD may be chronic in some patients. 4–7, 9, 10 Estimates of PTSD in HCT recipients have also remained relatively constant since the first studies conducted in the late 1990‟s, despite advances in transplant and supportive care. 8 Risk factors for PTSD have included longer length of hospital stay, pain, distress, more negative appraisals of the transplant, and lack of social support.…”

Section: Introductionmentioning

confidence: 99%

“…8 Risk factors for PTSD have included longer length of hospital stay, pain, distress, more negative appraisals of the transplant, and lack of social support. 4, 11–13 Data are mixed regarding associations with age, gender, marital status, transplant type, and history of acute graft versus host disease (GVHD). 3, 4, 6, 7 The presence of comorbidities and disease relapse have not been found to be associated with PTSD.…”

Section: Introductionmentioning

confidence: 99%

“…4, 11–13 Data are mixed regarding associations with age, gender, marital status, transplant type, and history of acute graft versus host disease (GVHD). 3, 4, 6, 7 The presence of comorbidities and disease relapse have not been found to be associated with PTSD. 3 Nevertheless, previous studies have tended to be relatively small, limiting statistical power to detect associations, and conducted relatively soon after transplant.…”

Section: Introductionmentioning

confidence: 99%

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Rates and Risk Factors for Post-Traumatic Stress Disorder Symptomatology among Adult Hematopoietic Cell Transplant Recipients and Their Informal Caregivers

Liang

Lee

Storer

et al. 2019

Biology of Blood and Marrow Transplantation

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Hematopoietic cell transplant (HCT) can cause significant distress in patients and their informal caregivers. Despite advances in reduced-intensity conditioning and supportive care, few recent studies have reported rates of clinically significant post-traumatic stress disorder (PTSD) symptomatology. Goals of the current study were to examine rates of PTSD and distress in patients and caregivers and to identify sociodemographic and clinical risk factors for PTSD. As part of an annual survivorship survey, 2157 HCT recipients and their caregivers were mailed self-report measures of PTSD and distress. Patients also completed self-report measures of sociodemographic information (eg, age, sex, employment status). Clinical variables (eg, time since transplant, transplant type) were captured in the transplant database. A total of 691 recipients (56% age 60 or above at the time of survey, 47% women, median 10.1 years post-HCT) and 333 caregivers provided PTSD data and were included in the current analyses. More caregivers reported PTSD (6.6%) than patients (3.3%; P = .02). Patients or caregivers who had PTSD reported significantly higher distress related to uncertainty, family strain, medical demands, finances, identity, and health burden (P < .0001) compared with those without PTSD. Patient but not caregiver PTSD was associated with more recent transplant (P = .01 and P = .16, respectively). Rates of PTSD are relatively low in long-term survivors of HCT and their caregivers. Nevertheless, results are consistent with other studies of cancer caregiving suggesting that caregivers often experience greater distress than patients. Timely referral to psychosocial services should be offered to both HCT recipients and caregivers reporting symptoms of PTSD.

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