Posttraumatic Stress Disorder and Comorbid Major Depression

Blanchard, Edward B.; Buckley, Todd C.; Hickling, Edward J.; Taylor, Ann E.

doi:10.1016/s0887-6185(97)00047-9

Cited by 222 publications

(156 citation statements)

References 13 publications

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“…Research in nonVeteran samples has found that PTSD and depression comorbidity is associated with significantly worse major role functioning than PTSD alone [12] and significantly worse social and occupational functioning than is associated with only PTSD or neither disorder [13]. The few studies conducted with Veterans have produced a similar pattern of findings.…”

Section: Introductionmentioning

confidence: 95%

Impact of comorbid depression on quality of life in male combat Veterans with posttraumatic stress disorder

et al. 2015

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Abstract-For Veterans with posttraumatic stress disorder (PTSD), depression is a highly comorbid condition. Both conditions have been associated with decreased quality of life, and research suggests that comorbid PTSD and depression may result in worse quality of life than PTSD alone. However, research is needed to elucidate the effect of comorbidity on a broader variety of quality of life domains. In this study, we used baseline data of 158 male combat Veterans taking part in a PTSD treatment trial and examined the unique relationships between quality of life domains and PTSD symptom clusters, major depressive disorder (MDD) diagnosis, and self-reported depressive symptoms. Veterans with comorbid PTSD-MDD reported significantly worse satisfaction-related quality of life than those with PTSD alone, although this finding was largely attributable to PTSD numbing symptoms. Subsequent analyses comparing the effect of numbing symptoms to depressive symptoms revealed that depression exerted a stronger influence, although numbing symptoms were still uniquely associated with quality of life. We discuss implications for treatment and research, as well as the need to address negative affect in Veterans with PTSD.

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Section: Introductionmentioning

confidence: 95%

Impact of comorbid depression on quality of life in male combat Veterans with posttraumatic stress disorder

et al. 2015

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“…[22][23][24][25][26] The Veterans Health Administration (VA) recently mandated nationwide primary care screening for depression and implemented a performance measure to gauge care quality vis-à-vis depression clinical practice guideline concordance. 27 Aside from directing the practitioner to assess for comorbid psychiatric conditions, VA and other depression guidelines approach MDD and PTSD as separate entities with distinct pathogenesis and treatment indications.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Depression–PTSD Comorbidity: Implications for Clinical Practice Guidelines and Primary Care-based Interventions

et al. 2007

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“…This result suggests that there is no symptom overlap. Other studies 32,33 have also found correlations between PTSD and depression, but their results indicated that the co-occurrence cannot be explained by the symptom overlap. Blanchard et al 32 found that PTSD and depression were different disorders.…”

Section: Discussionmentioning

confidence: 91%

“…Other studies 32,33 have also found correlations between PTSD and depression, but their results indicated that the co-occurrence cannot be explained by the symptom overlap. Blanchard et al 32 found that PTSD and depression were different disorders. When both diagnoses were met, victims of motor vehicle accidents showed more subjective distress and higher social malfunction than victims with PTSD, but not in the diagnosis of depression.…”

Section: Discussionmentioning

confidence: 91%

“…When both diagnoses were met, victims of motor vehicle accidents showed more subjective distress and higher social malfunction than victims with PTSD, but not in the diagnosis of depression. 32 On the basis of the multiple regression analysis, only dysphoria and expectations for the future significantly predicted PTSD controlling for all other predictors. This result indicates that being dysphoric and having lesser expectations for the future predict PTSD, thus supporting the assumption that PTSD and depression are related yet different reactions to trauma.…”

Section: Discussionmentioning

confidence: 96%

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Post-traumatic stress disorder and emotional distress in persons with spinal cord lesion

Nielsen

2003

Spinal Cord

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Study design: Questionnaire. Objective: To evaluate the prevalence of post-traumatic stress disorder (PTSD) and emotional distress in persons with recent onset of spinal cord lesion. Setting: Denmark. Methods: A total of 69 patients with paraplegia or tetraplegia from two rehabilitation centres in Denmark filled in the questionnaire. PTSD and emotional distress were assessed using the Harvard Trauma Questionnaire and the Medical-Based Emotional Distress Scale, 83 days on average after the spinal cord lesion. The level of neurological lesion and completeness were recorded adhering to the International Standards for Neurological Classification of Spinal Cord Injury. Results: The prevalence of PTSD was 20%. Patients with PTSD experienced significantly more symptoms of depression and more emotional distress than patients without PTSD. Age and neurological level were related to PTSD in patients with traumatic injuries, but not in patients with nontraumatic lesions. Conclusions: Persons with a recent onset of spinal cord lesions are at increased risk of having PTSD, and comorbidities such as depression and other symptoms of emotional distress.

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Posttraumatic Stress Disorder and Comorbid Major Depression

Cited by 222 publications

References 13 publications

Impact of comorbid depression on quality of life in male combat Veterans with posttraumatic stress disorder

Impact of comorbid depression on quality of life in male combat Veterans with posttraumatic stress disorder

Prevalence of Depression–PTSD Comorbidity: Implications for Clinical Practice Guidelines and Primary Care-based Interventions

Post-traumatic stress disorder and emotional distress in persons with spinal cord lesion

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