Posttraumatic epilepsy may be a state in which underlying epileptogenicity involves focal cortical dysplasia

Sakakura, Kazuki; Fujimoto, Ayataka; Arai, Yoshifumi; Ichikawa, Naoki; Sato, Keishiro; Baba, Shimpei; Inenaga, Chikanori; Matsumura, Akira; Ishikawa, Eiichi; Enoki, Hideo; Okanishi, Tohru

doi:10.1016/j.yebeh.2020.107352

Cited by 7 publications

(5 citation statements)

References 32 publications

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“…Indeed, these may share some similar pathogenicity. 3 Also, while a 4-layered cortex is identified in this neonatal FL model, similar to that seen in tissue from patients with PMG, it is not known how closely these fine microcircuit changes recapitulate what happens in patients. Regardless, the insights gleaned from this study regarding circuit reorganization leading to epileptogenesis are exciting and may lead to modifications of surgical approaches for some patients and inform new therapeutic avenues.…”

Section: Commentarymentioning

confidence: 79%

“… 2 Some studies suggest that the mechanisms for epileptogenesis may be similar in these different instances. 3 Often, refractory epilepsies of extratemporal origin are found to be associated with a focal cortical malformation on pathology. One such focal cortical malformation with a particularly high rate of refractory epilepsy is polymicrogyria (PMG).…”

Section: Commentarymentioning

confidence: 99%

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Seizing After Freezing: Layer-, Site-, and Cell-Type-Specific Rewiring Mediates Epileptogenesis Following Cortical Freeze Lesion in Mouse

Buchanan¹

2021

Epilepsy Curr

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Section: Commentarymentioning

confidence: 79%

Section: Commentarymentioning

confidence: 99%

Seizing After Freezing: Layer-, Site-, and Cell-Type-Specific Rewiring Mediates Epileptogenesis Following Cortical Freeze Lesion in Mouse

Buchanan¹

2021

Epilepsy Curr

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“…We therefore considered that the epileptic seizures had not involved rupture of the dermoid cyst. Epileptic seizures were naturally considered to potentially involve the interplay of the FCD and dermoid cysts in the brain parenchyma [ 15 , 16 , 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

Non-Ruptured Temporal Lobe Dermoid Cyst Concomitant with Focal Cortical Dysplasia Causing Temporal Lobe Epilepsy—A Case Report and Literature Review

et al. 2021

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Background: Intracranial dermoid cyst is a rare, benign, nonneoplastic tumor-like lesion that could cause seizures, headache, and hydrocephalus. We hypothesized that the temporal lobe dermoid cyst in combination with other factors were causing the epileptic seizure. Methods: We encountered a 17-year-old girl with anti-seizure medication-resistant epilepsy secondary to dermoid cyst located in the temporal region depicted on magnetic resonance imaging (MRI). She showed neither symptoms of meningitis nor rupture of the cyst according to serial MRI. We hypothesized that temporal lobe dermoid cyst in combination with other factors, such as focal cortical dysplasia (FCD), etc., was causing epileptic seizures in this case. She underwent dermoid cyst removal surgery with resection of the tip of the antero-inferior temporal lobe. Results: Histopathological study showed multiple small intramedullary dermoid cysts in the left antero-inferior temporal lobe in addition to MRI lesions and FCD. Conclusion: A patient with medically intractable epilepsy secondary to left temporal lobe dermoid cyst showed multiple intramedullary dermoid cysts and focal cortical dysplasia that might have interacted to create epileptogenicity. To our knowledge, this is the first case report of dermoid cyst concomitant with FCD.

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“…We also note that our patient required a hemispherotomy for complete seizure control and improvement in alertness; the propagation of abnormal electrical activities via other pathways (e.g., the anterior commissure) might disrupt the function on the unaffected hemisphere. While the etiology is a neonatal thalamic injury, lateralized hemispheric epilepsy network existed beyond the lesion [19][20][21]. Therefore, surgery would be considered to be one of the treatment options in case of lateralized EEG findings in addition to MR changes.…”

Section: Discussionmentioning

confidence: 99%

Successful Hemispherotomy in a Patient with Encephalopathy with Continuous Spikes and Waves during Sleep Related to Neonatal Thalamic Hemorrhage: A Case Report with Intracranial Electroencephalogram Findings

et al. 2021

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Neonatal thalamic hemorrhage is a strong risk factor for developing encephalopathy with continuous spikes and waves during sleep (ECSWS), even when not accompanied by widespread cortical destruction. The efficacy and indication of resective epilepsy surgery in such patients has not yet been reported. A 4-year-old boy was diagnosed with ECSWS based on strong epileptiform activation during sleep and neurocognitive deterioration. He had a history of left thalamic hemorrhage related to a straight sinus thrombosis during the newborn period. He presented with daily absence seizures that were refractory to medical treatment. At age 5, he underwent intracranial electroencephalogram (EEG) recording using depth and subdural strip electrodes placed in the left thalamus and over bilateral cortex, respectively. Interictal and ictal epileptiform discharges were observed in the thalamus, always preceded by discharges in the left or right parietal lobe. Left hemispherotomy successfully normalized the EEG of his unaffected hemisphere and extinguished his seizures. This is the first case report documenting resective epilepsy surgery in a patient with ECSWS due to neonatal thalamic injury without widespread cerebral destruction. Based on intracranial EEG findings, his injured thalamus did not directly generate the EEG abnormalities or absence seizures on its own. Patients with ipsilateral neonatal thalamic injury and even mild lateralized cortical changes may be candidates for resective or disconnective surgery for ECSWS.

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Posttraumatic epilepsy may be a state in which underlying epileptogenicity involves focal cortical dysplasia

Cited by 7 publications

References 32 publications

Seizing After Freezing: Layer-, Site-, and Cell-Type-Specific Rewiring Mediates Epileptogenesis Following Cortical Freeze Lesion in Mouse

Seizing After Freezing: Layer-, Site-, and Cell-Type-Specific Rewiring Mediates Epileptogenesis Following Cortical Freeze Lesion in Mouse

Non-Ruptured Temporal Lobe Dermoid Cyst Concomitant with Focal Cortical Dysplasia Causing Temporal Lobe Epilepsy—A Case Report and Literature Review

Successful Hemispherotomy in a Patient with Encephalopathy with Continuous Spikes and Waves during Sleep Related to Neonatal Thalamic Hemorrhage: A Case Report with Intracranial Electroencephalogram Findings

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