Posttraumatic Bacillus cereus Endophthalmitis: Clinical Characteristics and Antibiotic Susceptibilities

Mei, Feng; Lin, Jiaqi; Liu, Manli; Yang, Yao; Lin, Xiaofeng; Duan, Fang

doi:10.1155/2021/6634179

Cited by 7 publications

(6 citation statements)

References 32 publications

(19 reference statements)

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“…Intraocular injection of vancomycin and ceftazidime, combined with systemic administration of cefuroxime, cefazolin, or clindamycin, can reduce the rate of enucleation after trauma. 94 , 95 , 96 Systemic intravenous vancomycin combined with cefepime, tobramycin, or ofloxacin can reduce the incidence of post‐traumatic endophthalmitis. 97 It has been reported that hypersensitivity caused by intravitreal vancomycin may lead to haemorrhagic obstructive retinal vasculitis (HORV).…”

Section: Resultsmentioning

confidence: 99%

“…Combined vitreous injection of vancomycin and ceftazidime during surgical treatment has a certain effect on postoperative visual acuity improvement in patients with open globe injury and endophthalmitis. Intraocular injection of vancomycin and ceftazidime, combined with systemic administration of cefuroxime, cefazolin, or clindamycin, can reduce the rate of enucleation after trauma [94][95][96]. Systemic intravenous vancomycin combined with cefepime, tobramycin, or ofloxacin can reduce the incidence of post-traumatic endophthalmitis 97.…”

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confidence: 99%

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Guideline for the treatment of no light perception eyes induced by mechanical ocular trauma

Yan

Yang

et al. 2022

J Evidence Based Medicine

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Severe mechanical ocular trauma with no light perception (NLP) predicts a poor prognosis of visual acuity and enucleation of the eyeball. Since the innovative treatment concept of exploratory vitreoretinal surgery has developed and treatment technology has advanced, the outcomes of severe ocular trauma treatment in NLP patients have greatly improved. However, there remains a lack of unified standards for the determination, surgical indication, and timing of vitrectomy in NLP eye treatment. To address these problems, we aimed to create evidence‐based medical guidelines for the diagnosis, treatment, and prognosis of mechanical ocular trauma with NLP. Sixteen relevant recommendations for mechanical ocular trauma with NLP were obtained, and a consensus was reached. Each recommendation was explained in detail to guide the treatment of mechanical ocular trauma associated with NLP.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Guideline for the treatment of no light perception eyes induced by mechanical ocular trauma

Yan

Yang

et al. 2022

J Evidence Based Medicine

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“…We know that many variables, such as the course of disease, the virulence of microorganisms, the location of trauma, inflammation, injury degree of trauma, and retinal detachment, could influence FBCVA of PTBE. 4 , 32 , 33 …”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Value of Triggering Receptor Expressed on Myeloid Cells-1 in Post-Traumatic Bacterial Endophthalmitis

Tang

Zhang

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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Purpose To determine whether soluble-triggering receptor expressed on myeloid cells-1 (sTREM-1) could serve as a reliable diagnostic biomarker of post-traumatic bacterial endophthalmitis (PTBE). Methods Thirty-two patients (32 eyes) clinically diagnosed having PTBE were further divided into a culture-positive (CP) group and a culture-negative (CN) group. Sixty-two patients (62 eyes) without traumatic endophthalmic infection were also enrolled. Twenty-one eyes from 11 donors without globe ocular injuries were included as control group. Vitreous sTREM-1 levels were detected by ELISA. The expression and tissue distribution of TREM-1 were revealed by immunohistochemistry. The diagnostic value of sTREM-1 was determined by receiver operating characteristic curve (ROC). The correlation between sTREM-1 concentration and final best-corrected visual acuity (FBCVA) and Peyman endophthalmitis score (PES) were also assessed. Results The vitreous sTREM-1 level in the PTBE group was higher than that in noninfected group and control group ( P < 0.05). No remarkable difference was found between the CP group and the CN group in vitreous sTREM-1 levels ( P > 0.05). No remarkable difference was found between the noninfected group and the control group ( P > 0.05). No remarkable difference in TREM-1 level was found before and after intravitreal antibiotics ( P > 0.05). TREM-1 was selectively highly expressed on the surface of cell membrane of neutrophils and monocytes/macrophages infiltrated in vitreous and uveal of the PTBE group. The area under the ROC curve (AUC) was 0.79 (>0.75), with a medium diagnostic efficiency. The sensitivity and specificity of sTREM-1 to differentiate PTBE from the noninfected intraocular condition were 62.50% and 86.25% separately. A cutoff value >524.50 pg/mL for sTREM-1 was predicted to be PTBE. Vitreous sTREM-1 levels in PTBE group were positively correlated with PES ( r = 0.428, P < 0.05). However, sTREM-1 levels and FBCVA did not significantly correlate with one another ( P > 0.05). Conclusions The sTREM-1 was a promising diagnostic biomarker of PTBE, especially CN-PTBE. Vitreous sTREM-1 levels were linked with intraocular inflammation levels and severity of PTBE.

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“…For this reason, B. cereus s.l. is among the leading bacterial species that causes food poisoning outbreaks [ 1 ] and in certain severe cases, it can lead to endocarditis [ 4 ], endophthalmitis [ 5 ], and even death [ 6 , 7 , 8 ]. Regarding food products, B. cereus s.l.…”

Section: Introductionmentioning

confidence: 99%

A Genomic Analysis of the Bacillus Bacteriophage Kirovirus kirovense Kirov and Its Ability to Preserve Milk

Kazantseva

Skorynina

Piligrimova

et al. 2023

IJMS

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Bacteriophages are widely recognized as alternatives to traditional antibiotics commonly used in the treatment of bacterial infection diseases and in the food industry, as phages offer a potential solution in combating multidrug-resistant bacterial pathogens. In this study, we describe a novel bacteriophage, Kirovirus kirovense Kirov, which infects members of the Bacillus cereus group. Kirovirus kirovense Kirov is a broad-host-range phage belonging to the Caudoviricetes class. Its chromosome is a linear 165,667 bp double-stranded DNA molecule that contains two short, direct terminal repeats, each 284 bp long. According to bioinformatics predictions, the genomic DNA contains 275 protein-coding genes and 5 tRNA genes. A comparative genomic analysis suggests that Kirovirus kirovense Kirov is a novel species within the Kirovirus genus, belonging to the Andregratiavirinae subfamily. Kirovirus kirovense Kirov demonstrates the ability to preserve and decontaminate B. cereus from cow milk when present in milk at a concentration of 104 PFU/mL. After 4 h of incubation with the phage, the bacterial titer drops from 105 to less than 102 CFU/mL.

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Posttraumatic Bacillus cereus Endophthalmitis: Clinical Characteristics and Antibiotic Susceptibilities

Cited by 7 publications

References 32 publications

Guideline for the treatment of no light perception eyes induced by mechanical ocular trauma

Guideline for the treatment of no light perception eyes induced by mechanical ocular trauma

The Diagnostic Value of Triggering Receptor Expressed on Myeloid Cells-1 in Post-Traumatic Bacterial Endophthalmitis

A Genomic Analysis of the Bacillus Bacteriophage Kirovirus kirovense Kirov and Its Ability to Preserve Milk

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