Posttraumatic and depressive symptoms in β-endorphin dynamics

Savić, D; Knežević, Goran; Matić, Gordana; Damjanović, Svetozar; Spiric, Z.

doi:10.1016/j.jad.2015.03.063

Cited by 15 publications

(10 citation statements)

References 47 publications

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“…At the pathological level, opioidergic dysregulation has been suggested to play a role in the pathophysiology of various psychiatric disorders. Both increased and decreased levels of opioids were reported in schizophrenia and bipolar disorder, changes in endorphin plasma dynamics were shown in posttraumatic stress disorder, alteration in endorphinergic tone was documented in dissociative states, and alteration in opioid receptors availability and endorphin release were detected in borderline personality disorder (Prossin and others 2010; Savic and others 2015; Schmauss and Emrich 1985; Shah and Donald 1982). Unfortunately, data on the various psychiatric disorders are still sparse and show conflicting results.…”

Section: Discussionmentioning

confidence: 99%

“…More recently, pharmacological challenges, autoradiography, in situ hybridizations, positron emission tomography (PET), and functional magnetic resonance imaging (fMRI) studies have been performed in order to investigate the molecular mechanisms of both endogenous opiates and opioid drugs, such as morphine and its congeners. This, in turn, has shed light on the functions of endorphinergic signaling and its relevant role in an individual’s behavior; moreover, it has highlighted the involvement of the endorphinergic system and its dysfunction in the pathophysiology of various psychiatric disorders, including schizophrenia, posttraumatic stress disorder, borderline personality disorder, and affective disorders (Becerra and others 2006; Love and others 2009; Prossin and others 2010; Savic and others 2015; Schmauss and Emrich 1985; Shah and Donald 1982; Tuominen and others 2012; Zubieta and others 1999). However, evidence supporting an excess, deficiency, or dysregulation of endogenous endorphins in such psychiatric disorders is still sparse or inconsistent, prompting new models or hypotheses and further investigations.…”

Section: Introductionmentioning

confidence: 99%

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Opioidergic System and Functional Architecture of Intrinsic Brain Activity: Implications for Psychiatric Disorders

et al. 2020

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The opioidergic system and intrinsic brain activity, as organized in large-scale networks such as the salience network (SN), sensorimotor network (SMN), and default-mode network (DMN), play core roles in healthy behavior and psychiatric disorders. This work aimed to investigate how opioidergic signaling affects intrinsic brain activity in healthy individuals by reviewing relevant neuroanatomical, molecular, functional, and pharmacological magnetic resonance imaging studies in order to clarify their physiological links and changes in psychiatric disorders. The SN shows dense opioidergic innervations of subcortical structures and high expression levels of opioid receptors in subcortical-cortical areas, with enhanced or reduced activity with low or very high doses of opioids, respectively. The SMN shows high levels of opioid receptors in subcortical areas and functional disconnection caused by opioids. The DMN shows low levels of opioid receptors in cortical areas and inhibited or enhanced activity with low or high doses of opioids, respectively. Finally, we proposed a working model. Opioidergic signaling enhances SN and suppresses SMN (and DMN) activity, resulting in affective excitation with psychomotor inhibition; stronger increases in opioidergic signaling attenuate the SN and SMN while disinhibiting the DMN, dissociating affective and psychomotor functions from the internal states; the opposite occurs with a deficit of opioidergic signaling.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Opioidergic System and Functional Architecture of Intrinsic Brain Activity: Implications for Psychiatric Disorders

et al. 2020

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“…It is known that the immunopathology of AR and psychological effects are the main factors affecting the QOL in patients. It is noteworthy that the opioid peptide β -endorphin is not only a mediator of immune responses but also a predictor of mental health problems [30–32]. Mental health problems such as stress, depressive episodes, and anxiety disorders have been reported to be much more prevalent among patients with AR than among individuals without prevalent AR [33–35].…”

Section: Discussionmentioning

confidence: 99%

Correlation of Serumβ-Endorphin and the Quality of Life in Allergic Rhinitis

et al. 2016

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Background. Allergic rhinitis (AR) significantly impairs the quality of life of the patients; however, a questionnaire alone is an insufficient and subjective measure of this condition. Obtaining an objective clinical assessment of the level of impairment will be valuable for its treatment. β-Endorphin is one of the most important mediators of both mental state and specific immunity. Thus, we investigated the possibility of using β-endorphin as a biomarker for evaluating the impairment level in AR. Methods. This study included 48 patients with AR and 32 healthy volunteers. The serum β-endorphin level was determined by enzyme immunoassay, and the serum-specific IgE and total IgE levels were determined by immunoblot assay. The Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) was used to assess the impairment level in the symptom duration. Results. The β-endorphin concentration was significantly decreased in AR patients compared to the healthy controls (p = 0.000, p < 0.05). There was significant negative correlation between the impairment level and serum β-endorphin level (correlation coefficient: −0.468; p = 0.001; p < 0.05), but there was no association between the serum β-endorphin and total IgE levels (p = 0.947, p > 0.05). Conclusion. β-Endorphin is a systemic biomarker that has the potential to assess the impairment level in AR and may therefore be a novel therapeutic target for the treatment of AR.

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“…It is associated with other products of proopiomelanocortin and is synthesised in several peripheral tissues, including the gastrointestinal and reproductive tracts, the placenta and cells of the immune system as well as the anterior and intermediate lobes of the pituitary gland. As well as having an effect on pituitary function and its well known association with stress induced anaesthesia (Van der Kolk et al, 1985) and PTSD (Savic et al, 2015), it and other opioid peptides may also be involved in a wide range of systems including the cardiovascular, gastric, reproductive and immune systems (Lee and Wardlaw, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…The mathematical modelling employed in some recent studies may move in this direction (Savic et al, 2015;Sriram et al, 2012;Kim et al, 2016). The study of Kim et al (2016), for instance, considers a number of distinctive physiological features of the HPA axis and a more complete picture of the dynamics of stress disorders that have not been considered in previous models.…”

Section: Introductionmentioning

confidence: 99%

The evolution of the molecular response to stress and its relevance to trauma and stressor-related disorders

Watson

Brüne

Bradley

2016

Neuroscience & Biobehavioral Reviews

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The experience of "stress", in its broadest meaning, is an inevitable part of life. All living creatures have evolved multiple mechanisms to deal with such threats and challenges and to avoid damage to the organism that may be incurred from these stress responses. Trauma and stressor-related disorders are psychiatric conditions that are caused specifically by the experience of stress, though depression, anxiety and some other disorders may also be unleashed by stress. Stress, however, is not a mandatory criterion of these diagnoses. This article focuses on the evolution of the neurochemicals involved in the response to stress and the systems in which they function. This includes the skin and gut, and the immune system. Evidence suggests that responses to stress are evolutionarily highly conserved, have wider involvement than the hypothalamic pituitary adrenal stress axis alone, and that excessive stress responses can produce stressor-related disorders in both humans and animals.

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Posttraumatic and depressive symptoms in β-endorphin dynamics

Cited by 15 publications

References 47 publications

Opioidergic System and Functional Architecture of Intrinsic Brain Activity: Implications for Psychiatric Disorders

Opioidergic System and Functional Architecture of Intrinsic Brain Activity: Implications for Psychiatric Disorders

Correlation of Serumβ-Endorphin and the Quality of Life in Allergic Rhinitis

The evolution of the molecular response to stress and its relevance to trauma and stressor-related disorders

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