Posttrauma Symptoms in Childhood Leukemia Survivors and Their Parents

Stuber, Margaret L.; Christakis, Dimitri A.; Houskamp, Beth M.; Kazak, Anne E.

doi:10.1016/s0033-3182(96)71564-5

Cited by 236 publications

(176 citation statements)

References 35 publications

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“…Frequent cognitive intrusions and less frequent avoidance and hyperarousal is in line with the reports from previous studies [14,25], and suggest that intrusions among parents of children with cancer may not always reflect full-blown posttraumatic symptomatology. Phipps and colleagues (2005) raise the notion that there is indeed little evidence that stress-response symptoms in relation to childhood cancer are truly ''post-traumatic''.…”

Section: Discussionsupporting

confidence: 89%

Parent distress in childhood cancer: A comparative evaluation of posttraumatic stress symptoms, depression and anxiety

Norberg¹,

Boman²

2008

Acta Oncologica

136

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Section: Discussionsupporting

confidence: 89%

Parent distress in childhood cancer: A comparative evaluation of posttraumatic stress symptoms, depression and anxiety

Norberg¹,

Boman²

2008

Acta Oncologica

136

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“…adjustment [25][26][27][28][29][30] also have been assessed in childhood cancer survivors; and, although the results have been inconsistent, poorer outcomes for survivors generally are reported. In our own work, poorer physical and psychosocial quality of life was reported in survivors of childhood cancer who still were children and adolescents when they were studied compared with their age-matched and gender-matched counterparts from the general population.…”

mentioning

confidence: 99%

Educational and social late effects of childhood cancer and related clinical, personal, and familial characteristics

Barrera

Shaw

Speechley

et al. 2005

Cancer

275

252

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The protein human CC chemokine ligand 2 (CCL2, also known as monocyte chemoattractant protein 1 or MCP‐1) has been synthesized using a combination of solid phase peptide synthesis (SPPS) and native chemical ligation (NCL). The thioester‐peptide segment was synthesized using the sulfonamide safety‐catch linker and 9‐fluorenylmethoxycarbonyl (Fmoc) SPPS, and pseudoproline dipeptides were used to facilitate the synthesis of both CCL2 fragments. After assembly of the full‐length peptide chain by NCL, a glutathione redox buffer was used to fold and oxidize the CCL2 protein. Synthetic human CCL2 binds to and activates the CCR2 receptor on THP‐1 cells, as expected. CCL2 was crystallized and the structure was determined by X‐ray diffraction at 1.9‐Å resolution. The structure of the synthetic protein is very similar to that of a previously reported structure of recombinant human CCL2, although the crystal form is different. The functional CCL2 dimer for the crystal structure reported here is formed around a crystallographic twofold axis. The dimer interface involves residues Val9‐Thr10‐Cys11, which form an intersubunit antiparallel β‐sheet. Comparison of the CCL2 dimers in different crystal forms indicates a significant flexibility of the quaternary structure. To our knowledge, this is one of the first crystal structures of a protein prepared using the sulfonamide safety‐catch linker and NCL. © 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94: 350–359, 2010. This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com

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“…What is certain is that staying in such a restrictive condition for a long time caused emotional and psycho-social problems for these mothers so that all the participants stated that they suffered from some degree of depression and fatigue. Other studies have also confirmed these findings and shown that these mothers endure severe emotional distress and experience a range of psycho-social problems (Stuber et al, 1996;Sloper, 2000).…”

Section: Discussionmentioning

confidence: 54%

“…Many physical (Meltzer and Mindell, 2006;Klassen et al, 2008) (headache, backache, anorexia, digestion disorders, palpitation) and emotional (von Essen et al, 2004;Grinyer, 2006) (senses of weariness, despair, anger, stress, anxiety and depression) problems have been reported by such mothers. Studies even have indicated the existence of the symptoms of the posttraumatic stress syndrome in mothers following treatment (Stuber et al, 1996;Kazak et al, 1997). Since 1970, many investigations have been carried out on different aspects of childhood cancer, which mostly have focused on the parent-child adaptability process (Khoury, 2013), psychological impacts of diseases on children and families (Long and Marsland, 2011), and the effects of diseases on the family system (Patterson et al, 2004;Woodgate, 2006;Tedford and Price, 2011).…”

Section: Introductionmentioning

confidence: 99%

Caring for a Child with Cancer: Impact on Mother's Health

Rafii

Oskouie²,

Shoghi

2014

Asian Pacific Journal of Cancer Prevention

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The life of a mother undergoes a dramatic change after a child is diagnosed with cancer. The present study aimed to determine effects on the everyday life process and health status of mothers with children suffering from leukemia. This qualitative study was based on a grounded theory approach with sixteen mothers. The results indicate that after onset of disease in their children, they marginalized their own health and tied their identities to taking care of the child and keeping the child healthy by ignoring themselves, becoming imprisoned in a taking-care-of-the-child position, and trying very hard for seek balance and stability Enduring physical pressures on the one hand, and constantly attempting to achieve balance and stability in family processes on the other hand, gradually cause exhaustion. It seems that health care providers and nurses should pay much more attention to the health status of this group of mothers.

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Posttrauma Symptoms in Childhood Leukemia Survivors and Their Parents

Cited by 236 publications

References 35 publications

Parent distress in childhood cancer: A comparative evaluation of posttraumatic stress symptoms, depression and anxiety

Parent distress in childhood cancer: A comparative evaluation of posttraumatic stress symptoms, depression and anxiety

Educational and social late effects of childhood cancer and related clinical, personal, and familial characteristics

Caring for a Child with Cancer: Impact on Mother's Health

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