Posttransplant Neopterin Excretion in Renal Allograft Recipients—a Reliable Diagnostic Aid for Acute Rejection and a Predictive Marker of Long-Term Graft Survival

Reibnegger, Gilbert; Aichberger, C.; Fuchs, Dietmar; Hausen, Arno; Spielberger, M; Werner, Ernst R.; Margreiter, Raimund; Wachtehr, Helmut

doi:10.1097/00007890-199107000-00012

Cited by 86 publications

(45 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Follow up of solid allograft recipients (kidneys, liver, pancreas, heart) b y neopterin measurement has become a powerful tool in surveillance after transplantation surgery (95)(96)(97)(98). Neopterin measurement in morning urine or senlm/plasma allows to early detect inmmnological complications regarding organ rejection or v iral infections.…”

Section: Neopterin In Organ Transplantationmentioning

confidence: 99%

See 1 more Smart Citation

The Importance of Neopterin as a Laboratory Diagnostic Marker of Immune Activation

et al. 1999

Self Cite

View full text Add to dashboard Cite

SummaryNeopterin is produced and secreted in large amounts by interferon-g stimulated human monocytes/ macrophages. Neopterin measurement in urine and semm provides a usefi.ll possibility to estimate the dcgree of ccllular (Thl-type) immune activation, which is directed against viral infections, intracellular bacteria, and certain parasites. Also in malignancy, autoimmw1e diseases and allograft rejection episodes neopterin sensitively reflects the extent of cellular immune activation. Determination of neoptcrin concentrations can be conveniently performed by immunoassay like ELISA or RIA, and HPLC. The major diagnostic applications of neopterin monitoring are: surveillancc of the immw1e status of organ recipients, therapy control and prognosis of diseasc progression in tumor diseascs and HIV infections and also detection of unknown infections in e.g. blood banks. High neopterin levels are strongly associated with oxidative stress, opening an additional application field of ncopterin monitoring to estimate the extent of tissue damagc in the course of immune activation.

show abstract

Section: Neopterin In Organ Transplantationmentioning

confidence: 99%

“…Also in pancreas transplantation, measurement of neopterin in the pancreas juice in parallel to serum or urine provides additional information about the origin of immune activation (102). In general, studies have shown that neopterin is a properly predictive marker for long-term graft survival (98).…”

Section: Neopterin In Organ Transplantationmentioning

confidence: 99%

The Importance of Neopterin as a Laboratory Diagnostic Marker of Immune Activation

et al. 1999

Self Cite

View full text Add to dashboard Cite

show abstract

“…In humans, elevations of neopterin in serum and urine have been found in viral infections including human immunodeficiency virus type 1, various malignant disorders, autoimmune diseases and during allograft rejection episodes [5][6][7][8][9][10]. Significant associations between enhanced neopterin and IFN-g production have been obtained also in patients [11], and monitoring of neopterin concentrations has turned out to be a sensitive and useful marker to estimate the activation of Th1-cells [6].…”

Section: Introductionmentioning

confidence: 99%

Association between insulin resistance, body mass and neopterin concentrations

Ledochowski

Murr

Widner

et al. 1999

Clinica Chimica Acta

Self Cite

View full text Add to dashboard Cite

“…Neopterin concentrations are therefore thought to reflect both systemic immune and inflammatory responses [32]. Serum or urinary neopterin can be used as a biomarker of systemic immune and inflammatory responses in a wide range of disorders including malignancies, viral infections, transplant rejection, advanced age or atherosclerosis and its complications [32][33][34][35][36][37][38][39][40]. Neopterin is stable in refrigerated samples for up to 2 weeks, and samples for repeat assessment may be collected and stored by the patient between regular office visits with the need for repeated puncture circumvented.…”

Section: Discussionmentioning

confidence: 99%

Neoadjuvant combination therapy with trastuzumab in a breast cancer patient with synchronous rectal carcinoma: a case report and biomarker study

et al. 2017

View full text Add to dashboard Cite

Abstract:We report a patient who presented with synchronous second primary human epidermal growth factor receptor (HER)-2-positive breast cancer and rectal cancer that both required simultaneous neoadjuvant therapy. A modified regimen combining anti-HER-2 monoclonal antibody trastuzumab with chemotherapy and external beam radiation was selected. An organ-preserving surgical procedure was possible both in the breast and the rectum. Citrulline decreased rapidly after the start of the treatment, and then gradually returned to pre-treatment levels after the completion of chemoradiation. Urinary neopterin concentrations exhibited a fluctuating course. Both serum neopterin and C-reactive protein concentrations were more or less stable during the initial administration of trastuzumab, paclitaxel and carboplatin and then increased steeply during chemoradiation and subsequently declined to pre-treatment levels during the weekly trastuzumab administration. Changes were observed in the serum retinol concentrations. A decline in lymphocyte counts was accompanied by marked changes in peripheral blood cell count-derived ratios. The present case report demonstrates a successful combination of two neoadjuvant regimens in a patient with two synchronous different second primary tumors. Data from this case also illustrate the use of biomarkers for monitoring of intensive therapeutic regimens in medical and radiation oncology.

show abstract

Posttransplant Neopterin Excretion in Renal Allograft Recipients—a Reliable Diagnostic Aid for Acute Rejection and a Predictive Marker of Long-Term Graft Survival

Cited by 86 publications

References 0 publications

The Importance of Neopterin as a Laboratory Diagnostic Marker of Immune Activation

The Importance of Neopterin as a Laboratory Diagnostic Marker of Immune Activation

Association between insulin resistance, body mass and neopterin concentrations

Neoadjuvant combination therapy with trastuzumab in a breast cancer patient with synchronous rectal carcinoma: a case report and biomarker study

Contact Info

Product

Resources

About