Posttransplant Malaria: First Case of Transmission of Plasmodium Falciparum From a White Multiorgan Donor to Four Recipients

Chiche, Laurence; Lesage, Anne; Duhamel, Chantal; Salamé, Ephrem; Malet, Michèle; Samba, D.; Ségol, P; Treilhaud, M.

doi:10.1097/00007890-200301150-00031

Cited by 64 publications

(50 citation statements)

References 6 publications

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“…The heart recipient developed symptoms 5 days posttransplantation and died as a direct consequence of the infection. Parasitemia was detected 8 days posttransplantation in the liver recipient, and the kidney recipients received preventive antimalarial therapy (81). All three recipients had favorable outcomes.…”

Section: Routes Of Transmissionmentioning

confidence: 98%

“…Included in these data are the data from three publications that identified cases of malaria following multiorgan donation (81,120,245). In the cases reported by Fischer et al in 1999 following organ donation from an immigrant from an endemic zone (120), malaria due to P. vivax was detected in the liver recipient (28 days posttransplantation), heart recipient (suspected due to a rise in specific antibodies against P. vivax 12 months posttransplantation), and kidney recipient (6 weeks posttransplantation).…”

Section: Routes Of Transmissionmentioning

confidence: 99%

“…In the recipient of the second kidney, there was no clinical or laboratory evidence of malaria infection (120). Chiche et al (81) described another case of transmission of P. falciparum from a common donor who had a history of recent travel to an area of endemicity, although the cause of death was not attributed to acute malaria infection. The heart recipient developed symptoms 5 days posttransplantation and died as a direct consequence of the infection.…”

Section: Routes Of Transmissionmentioning

confidence: 99%

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Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

et al. 2008

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SUMMARY In recent years, the increasing number of donors from different regions of the world is providing a new challenge for the management and selection of suitable donors. This is a worldwide problem in most countries with transplantation programs, especially due to the increase in immigration and international travel. This paper elaborates recommendations regarding the selection criteria for donors from foreign countries who could potentially transmit tropical or geographically restricted infections to solid-organ transplant recipients. For this purpose, an extensive review of the medical literature focusing on viral, fungal, and parasitic infections that could be transmitted during transplantation from donors who have lived or traveled in countries where these infections are endemic has been performed, with special emphasis on tropical and imported infections. The review also includes cases described in the literature as well as risks of transmission during transplantation, microbiological tests available, and recommendations for each infection. A table listing different infectious agents with their geographic distributions and specific recommendations is included.

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Section: Routes Of Transmissionmentioning

confidence: 98%

Section: Routes Of Transmissionmentioning

confidence: 99%

Section: Routes Of Transmissionmentioning

confidence: 99%

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Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

et al. 2008

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“…Malaria transmission has been reported in kidney 7 , hematopoietic stem cell 12 and multiple tissue transplantation 4 .…”

Section: Discussionmentioning

confidence: 99%

The monitoring of hematopoietic stem cell transplant donors and recipients from endemic areas for malaria

Inoue

Machado

Lima

et al. 2010

Rev. Inst. Med. trop. S. Paulo

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SUMMARYMalaria is an unusual complication after hematopoietic stem cell transplantation in non-endemic countries. However, transplant candidates, recipients and donors living in endemic regions frequently report previous episodes of malaria. This fact could represent an important risk for immunosuppressed recipients that could develop severe malaria cases. We report a case of hematopoietic stem cell transplant (HSCT) in which the donor had a history of previous malaria, and close monitoring was performed before and after procedure by parasitological and molecular tests. The donor presented Plasmodium vivax in thick blood smears one month after transplant and was treated according to Brazilian Health Ministry guidelines. The polymerase chain reaction (PCR) was able to detect malaria infection in the donor one week earlier than thick blood film. Even without positive results, the recipient was pre-emptively treated with chloroquine in order to prevent the disease. We highlight the importance of monitoring recipients and donors in transplant procedures with the aim of reducing the risk of malaria transmission.

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“…Transmission of the disease has been reported with many organ transplants, as kidney (Holzer et al, 1985), bone marrow (Abdelkefi et al, 2004), and multiorgan (Chiche et al, 2003). Malarial antibodies also have been detected in a recipient of a heart transplant who received his graft from an infected donor (Fischer et al, 1999).…”

Section: Malariamentioning

confidence: 99%

Infectious Complications in Kidney Transplantation

El‐Husseini¹,

Hassan²

2011

After the Kidney Transplant - The Patients and Their Allograft

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Posttransplant Malaria: First Case of Transmission of Plasmodium Falciparum From a White Multiorgan Donor to Four Recipients

Cited by 64 publications

References 6 publications

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation

The monitoring of hematopoietic stem cell transplant donors and recipients from endemic areas for malaria

Infectious Complications in Kidney Transplantation

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