Posttranslational modifications in pathogenesis of PCOS

Wei, Huimei; Huo, Peng; Liu, Shun; Hua, Huang; Zhang, Shun

doi:10.3389/fendo.2022.1024320

Cited by 7 publications

(3 citation statements)

References 89 publications

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“…The severity of PCOS increases with increasing levels of insulin and androgen. On the one hand, hyperinsulinemia can affect the synthesis and secretion of androgen levels in ovarian theca cells, reducing the biosynthesis of liver SHBG and IGFBP-1 [ 5 , 8 , 60 ]. On the other hand, an increase in androgen levels can stimulate visceral adipose tissue (VAT) and produce free fatty acids (FFA), leading to insulin resistance [ 5 , 8 , 54 ].…”

Section: Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

Therapeutic Effects and Molecular Mechanism of Chlorogenic Acid on Polycystic Ovarian Syndrome: Role of HIF-1alpha

2023

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Chlorogenic acid (CGA) is a powerful antioxidant polyphenol molecule found in many diets and liquid beverages, playing a preventive and therapeutic role in various diseases caused by oxidative stress and inflammation. Recent research has found that CGA can not only improve clinical symptoms in PCOS patients but also improve follicular development, hormone status, and oxidative stress in PCOS rats, indicating the therapeutic effect of CGA on PCOS. Notably, our previous series of studies has demonstrated the expression changes and regulatory mechanisms of HIF-1alpha signaling in PCOS ovaries. Considering the regulatory effect of CGA on the HIF-1alpha pathway, the present article systematically elucidates the therapeutic role and molecular mechanisms of HIF-1alpha signaling during the treatment of PCOS by CGA, including follicular development, steroid synthesis, inflammatory response, oxidative stress, and insulin resistance, in order to further understand the mechanisms of CGA effects in different types of diseases and to provide a theoretical basis for further promoting CGA-rich diets and beverages simultaneously.

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Section: Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

Therapeutic Effects and Molecular Mechanism of Chlorogenic Acid on Polycystic Ovarian Syndrome: Role of HIF-1alpha

2023

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“…PCOS is a common disease affecting 5 to 18% of women worldwide. This causes symptoms, such as an excess of androgens, anovulation, and polycystic ovaries, which lead to various complications [13,14]. EMS is also a disease in many women, in which the endometrium attaches to the extrauterine tissue and proliferates.…”

Section: Introductionmentioning

confidence: 99%

Effects of Decamethylcyclopentasiloxane on Reproductive Systems in Female Rats

Lee

Kim

Park

et al. 2023

Toxics

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The female reproductive system becomes fertile through the action of hormones involved in the hypothalamic-pituitary-ovarian axis. On the other hand, estrogen-like endocrine disruptors released into the environment come into contact with humans by various routes and affect the reproductive system. Exposure to these chemicals can cause problems with the reproductive process, from egg ovulation to implantation, or cause female reproductive diseases. These reproductive problems cause infertility. Decamethylcyclopentasiloxane (D5) is used for lubrication in silicone polymers, households, and personal care products. In the case of D5, it is discharged through factory wastewater and can bioaccumulate. Therefore, it accumulates in the human body. In this study, D5 was administered orally for four weeks to determine the effects of D5 on the reproductive process. As a result, D5 increases the number of follicles in the ovary and suppresses the expression of genes related to the growth of follicles. In addition, it increases the gonadotropin hormone, inducing estradiol enhancement and progesterone reduction. Because of these changes in the reproductive system when exposed to D5, the industry should reconsider using D5.

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“…In addition, it has been shown that follicular excess and increased size of the ovaries in PCOS are associated with insulin resistance (IR) and that the number of follicles may also be a predictor of IR [6]. However, the pathogenesis of PCOS is not yet perfect, and there are many hypotheses about different pathogenesis factors, such as chronic low-grade inflammation, genetic factors, lifestyle, post-translational modification mechanism of PCOS, and ovarian autophagy mechanism [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Screening of potential biomarkers for polycystic ovary syndrome and identification of expression and immune characteristics

Liu,

Zhao,

Meng

et al. 2023

PLoS ONE

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Background Polycystic ovary syndrome (PCOS) seriously affects the fertility and health of women of childbearing age. We look forward to finding potential biomarkers for PCOS that can aid clinical diagnosis. Methods We acquired PCOS and normal granulosa cell (GC) expression profiles from the Gene Expression Omnibus (GEO) database. After data preprocessing, differentially expressed genes (DEGs) were screened by limma package, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis and Gene Set Enrichment Analysis (GSEA) were performed. Recursive feature elimination (RFE) algorithm and the least absolute shrinkage and selection operator (LASSO) Cox regression analysis were used to acquire feature genes as potential biomarkers. Time-dependent receiver operator characteristic curve (ROC curve) and Confusion matrix were used to verify the classification performance of biomarkers. Then, the expression characteristics of biomarkers in PCOS and normal cells were analyzed, and the insulin resistance (IR) score of samples was computed by ssGSEA. Immune characterization of biomarkers was evaluated using MCP counter and single sample gene set enrichment analysis (ssGSEA). Finally, the correlation between biomarkers and the scores of each pathway was assessed. Results We acquired 93 DEGs, and the enrichment results indicated that most of DEGs in PCOS group were significantly enriched in immune-related biological pathways. Further screening results indicated that JDP2 and HMOX1 were potential biomarkers. The area under ROC curve (AUC) value and Confusion matrix of the two biomarkers were ideal when separated and combined. In the combination, the training set AUC = 0.929 and the test set AUC = 0.917 indicated good diagnostic performance of the two biomarkers. Both biomarkers were highly expressed in the PCOS group, and both biomarkers, which should be suppressed in the preovulation phase, were elevated in PCOS tissues. The IR score of PCOS group was higher, and the expression of JDP2 and HMOX1 showed a significant positive correlation with IR score. Most immune cell scores and immune infiltration results were significantly higher in PCOS. Comprehensive analysis indicated that the two biomarkers had strong correlation with immune-related pathways. Conclusion We acquired two potential biomarkers, JDP2 and HMOX1. We found that they were highly expressed in the PCOS and had a strong positive correlation with immune-related pathways.

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Posttranslational modifications in pathogenesis of PCOS

Cited by 7 publications

References 89 publications

Therapeutic Effects and Molecular Mechanism of Chlorogenic Acid on Polycystic Ovarian Syndrome: Role of HIF-1alpha

Therapeutic Effects and Molecular Mechanism of Chlorogenic Acid on Polycystic Ovarian Syndrome: Role of HIF-1alpha

Effects of Decamethylcyclopentasiloxane on Reproductive Systems in Female Rats

Screening of potential biomarkers for polycystic ovary syndrome and identification of expression and immune characteristics

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