“…3,7,24 The mechanisms responsible for hyperpolarization are believed to be dependent on the length of the impulse train: activation of nodal slow K conductance following brief trains, 3,24 and activation of the electrogenic Na + /K + pump with longer trains. 4,6,19,20 Although both phenomena are thought to occur in human motor and sensory axons, 2,17,18,[22][23][24] it is not clear whether rate-dependent excitability change has a role in the symptomatology or pathophysiology of human neuropathies.In demyelinating neuropathy, conduction block (after a single impulse) of the sensory fibers is considered to be associated with impairment of elementary sensations such as touch, pin-prick, or position. More complicated sensations, such as vibratory sensation and texture discrimination, may be affected by activity-dependent conduction block or the exact timing of train impulses.…”