Postsystolic shortening as an index of regional myocardial ischemia in an experimental model

Coetzee, André; Fourie, Paula

doi:10.1016/1053-0770(91)90003-c

Cited by 11 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SB defined as the bulging of the myocardium after the end of diastole, was determined using the equation: SB = 100 × (Maximum segment length during systole − EDL)/EDL [12]. PSS defined as the shortening after the end of systolic ejection was determined using the equation: PSS = 100 × (ESL − Minimum segment length during diastole)/EDL [13].…”

Section: Experimental Protocol For Acute Myocardial Infarctionmentioning

confidence: 99%

Selective opening of mitochondrial ATP-sensitive potassium channels during surgically induced myocardial ischemia decreases necrosis and apoptosis

Wakiyama

2002

European Journal of Cardio-Thoracic Surgery

View full text Add to dashboard Cite

show abstract

Section: Experimental Protocol For Acute Myocardial Infarctionmentioning

confidence: 99%

Selective opening of mitochondrial ATP-sensitive potassium channels during surgically induced myocardial ischemia decreases necrosis and apoptosis

Wakiyama

2002

European Journal of Cardio-Thoracic Surgery

View full text Add to dashboard Cite

show abstract

“…With all methods of measuring the response of the normal left ventricular myocardium to a sudden adjacent ischaemic insult, we found no evidence of a compensatory increase in function in that remaining normal myocardium. These data are in conflict with the results of Gallagher and colleagues [24] and Noma and colleagues [6], but are supported by the work of others [17,[25][26][27] in which remote normal area function was not augmented during regional ischaemia. The same lack of augmentation has been noted in the right ventricle [28].…”

Section: Discussionmentioning

confidence: 56%

Regional myocardial function during contiguous ischaemia in an anaesthetized canine model: comparison of six methods of measurement

Reitan

Kien

Moore

et al. 1994

British Journal of Anaesthesia

View full text Add to dashboard Cite

During acute myocardial ischaemia, the function of the unaffected muscle is the primary determinant of residual cardiac performance. We compared six methods of measuring regional function in the remaining non-ischaemic segment after acute ligation of the left anterior descending (LAD) coronary artery in 16 dogs. Preparation included left ventricular micromanometers, regional sonomicrometer transducers to measure segment length and wall thickness, caval occluders and left atrial catheters for injection of radioactive microspheres to measure regional blood flow. Pulmonary artery, central venous and systemic arterial pressures were measured and regional coronary venous blood was collected for direct myocardial oxygen consumption (VO2) calculations. Under basal high-dose fentanyl-neuromuscular blocker anaesthesia, the LAD was occluded after addition of halothane or isoflurane at 0.5 or 1.5 MAC concentrations. Regional myocardial function of the non-ischaemic segment was assessed by the following computer-derived indices: percent systolic wall thickening (% WT), velocity of shortening (vs), percent systolic shortening (%SS), regional stroke work (RSW), regional preload recruitable stroke work (RPRSW) and regional end-systolic elastance (Ees). No index demonstrated enhanced function in the non-ischaemic segment after LAD ligation and all monitors, except Ees, were sensitive to depression of function represented by a decrease in values after administration of halothane and isoflurane (P < 0.05). Ees values increased with the addition of isoflurane and remained constant with halothane. Circulating concentrations of catecholamines were unchanged after ischaemia, while inhalation agents caused a decrease in the concentrations of adrenaline and dopamine (P < 0.05), but not noradrenaline.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

“…Recognizing this symptom in patients suffering from myocardial infarction directly after revascularization, improves the prognosis in the reversion back to normal contractile function. However, when this occurs in patients with arterial hypertension or dilated cardiomyopathy, then it is associated with impaired diastolic function, as detected by Tissue Doppler Imaging or Speckle Tracking Echocardiography [9–12]. In patients with complete left bundle branch block, the septal flash consequently also occurs leading to postsystolic shortening.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have focused on markers of decreased late diastolic myocardial compliance, reflected by restrictive physiology of the RV [8]. Nonetheless, some trials have demonstrated the postsystolic shortening phenomenon (PSS) to be a mechanism for early diastolic dysfunction in left-sided lesions [9–12]. Only one trial however shows a PSS within the RV, where an elegant model of right ventricular lateral wall activation was presented [13].…”

Section: Introductionmentioning

confidence: 99%

Postsystolic Shortening Is Associated with Altered Right Ventricular Function in Children after Tetralogy of Fallot Surgical Repair

Pietrzak

Werner

2017

PLoS ONE

View full text Add to dashboard Cite

The aim of the study was to determine whether segmental interactions, as expressed by postsystolic shortening (PSS), affects RV mechanics and are connected with impaired systolic and diastolic function in rTOF children. Patients and Methods: 55 rTOF adolescent (study group), and 34 healthy volunteers (control group) were examined using classical Doppler flow (Doppler), Tissue Doppler Imaging (TDI) and Speckle Tracking Echocardiography (STE). PSS was found to occur when time to peak (TTP) was longer than pulmonary valve closure time (PVCT). TTP and strain were derived from RV lateral segments—basal (BL), medial (ML) and apical (AL) in STE. PVCT was measured from the beginning of QRS complex in the ECG to the termination of Doppler flow at the pulmonary valve. TDI was obtained at the lateral tricuspid annulus site and the systolic (S′), early (E′) and late diastolic (A’) peak velocities were measured along with isovolumic contraction (IVCT), and relaxation (IVRT) time. PW was used to measure early tricuspid inflow velocity (E) for calculating the E/E’ ratio. The TDI data in patients with PSS presence (TTP>PVCT) and those in whom it did not occur (TTP≤PVCT) were compared. Results: PSS in BL, ML and AL were observed respectively in: 27(51,9%), 9 (18%), and 8 (16,7%) patients. Mean values of TTP in BL, ML, and AL were respectively: 420.6±55.5ms, 389.8±50.0ms and 366.7±59.0ms. PVCT mean value was 396.6±33.5ms. In the study group, the mean E’ in TTP>PVCT was significantly lower (4.8±1.8 cm/s) compared to mean E’ in TTP≤PVCT (8.4±2.6 cm/s), p<0.01. The average E/E’ was significantly higher in TTP>PCVT than in TTP≤PVCT, respectively 21.6±7.3 vs 12.2±5.1, p<0.05. IVRT was significantly prolonged in TTP>PVCT compared to IVRT in TTP≤PVCT, respectively 95.9±38.7 vs 77.0±35.1, p<0.05. Furthermore, in TTP>PVCT, significantly higher strain in BL (-28.8±8.7%) was observed when compared to that parameter in TTP≤PVCT (-35.3±13.1%), p <0.05. Conclusions: Tissue Doppler Echocardiography and Speckle Tracking Echocardiography are useful techniques for detecting regional systolic and diastolic dysfunction in children after Tetralogy of Fallot surgical repair. Postsystolic shortening in the basal lateral segment is commonly seen in children after the Tetralogy of Fallot surgical repair, and is associated with altered right ventricular systolic and diastolic function.

show abstract

Postsystolic shortening as an index of regional myocardial ischemia in an experimental model

Cited by 11 publications

References 23 publications

Selective opening of mitochondrial ATP-sensitive potassium channels during surgically induced myocardial ischemia decreases necrosis and apoptosis

Selective opening of mitochondrial ATP-sensitive potassium channels during surgically induced myocardial ischemia decreases necrosis and apoptosis

Regional myocardial function during contiguous ischaemia in an anaesthetized canine model: comparison of six methods of measurement

Postsystolic Shortening Is Associated with Altered Right Ventricular Function in Children after Tetralogy of Fallot Surgical Repair

Contact Info

Product

Resources

About