Postsynaptic plasticity of Purkinje cells in mice is determined by molecular identity

Voerman, Stijn; Urbanus, Bastiaan H A; Schonewille, Martijn; White, Joshua J.; Zeeuw, Chris I. De

doi:10.1038/s42003-022-04283-y

Cited by 5 publications

(11 citation statements)

References 29 publications

(34 reference statements)

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“…Mouse strains in which zebrin stripes are intrinsically visualized are useful for this purpose. So far, EAAT4‐EGFP mice (Voerman et al., 2022), Aldoc‐Venus mice (Fujita et al., 2014), and Rgs8‐EGFP mice (Viet et al., 2021) have been used for this purpose. The two latter strains were used in the present study.…”

Section: Discussionmentioning

confidence: 99%

Topographic organization in the cerebellar nuclei and inferior olive in relation to cerebellar hemispheric lobules in the mouse: Distinction between crus I and neighboring lobules

Owusu-Mensah

Sarpong

Sugihara

2023

J of Comparative Neurology

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The parallel closed‐loop topographic connections between subareas of the inferior olive (IO), cerebellar cortex, and cerebellar nuclei (CN) define the fundamental modular organization of the cerebellum. The cortical modules or zones are organized into longitudinal zebrin stripes which are extended across transverse cerebellar lobules. However, how cerebellar lobules, which are related to the cerebellar functional localization, are incorporated into the olivo‐cortico‐nuclear topographic organization has not been fully clarified. In the present study, we analyzed the lobular topography in the CN and IO by making 57 small bidirectional tracer injections in the lateral zebrin‐positive stripes equivalent with C2, D1, and D2 zones in every hemispheric lobule in zebrin stripe‐visualized mice.C2, D1, and D2 zones were connected to the lateral part of the posterior interpositus nucleus (lPIN), and caudal and rostral parts of the lateral nucleus (cLN, rLN), respectively, and from the rostral part of the medial accessory olive (rMAO), and ventral and dorsal lamellas of the PO (vPO, dPO), respectively, as reported. Within these areas, crus I was specifically connected to the ventral parts of the lPIN, cLN, and rLN, and from the rostrolateral part of the rMAO and the lateral parts of the vPO and dPO.The results indicated that the cerebellar modules have lobule‐related subdivisions and that crus I is topographically distinct from other lobules. We speculate that crus I and crus I‐connected subdivisions in the CN and IO are involved more in nonmotor functions than other neighboring areas in the mouse.

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Section: Discussionmentioning

confidence: 99%

Topographic organization in the cerebellar nuclei and inferior olive in relation to cerebellar hemispheric lobules in the mouse: Distinction between crus I and neighboring lobules

Owusu-Mensah

Sarpong

Sugihara

2023

J of Comparative Neurology

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“…[1,2] Due to the continuously Images adapted from ref. [28]. The images from Figure 1c were adapted from ref.…”

Section: Modulation Of Purkinje Cell Activitymentioning

confidence: 99%

“…The images from Figure 1c were adapted from ref. [28], an open access article distributed under the terms of the Creative Commons CC BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.…”

Section: Modulation Of Purkinje Cell Activitymentioning

confidence: 99%

“…Regional heterogeneity of cell types is an important aspect of cerebellar function (Figure 1B). [7,[28][29][30][31][32][33] PCs with unique molecular profiles can be distinguished and aggregate together to form bands or "stripes" (Figure 1B,C). [34] These bands are highly organized, each receiving CF and PF inputs from specific regions of the inferior olive and pontine nuclei, and projecting to specific regions of the CN (for review see ref.…”

Section: Relation Between Molecular Diversity and Physiological Prope...mentioning

confidence: 99%

“…[32,46,48] Additionally, PCs located in Aldoc+ versus Plcb4+ bands have distinct propensities for postsynaptic as well as intrinsic plasticity. [28,29,31,49] Plcb4+ PCs have a higher propensity for PF-PC LTD compared to Aldoc+ PCs, meaning that the same induction protocols lead to a larger reduction in synaptic strength (Figure 1B). [28,29] The differences in LTP are more ambiguous, as inducing LTP with low frequency (1 Hz) PF stimulation results in increased LTP in Plcb4+ PCs, [31] while stimulation at higher frequencies (8 at 100 Hz) does not.…”

Section: Ebf2 Actively Suppresses the Aldolase C Phenotype And Thus E...mentioning

confidence: 99%

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Plasticity mechanisms of genetically distinct Purkinje cells

Voerman,

Broersen,

Swagemakers

et al. 2024

BioEssays

Self Cite

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Despite its uniform appearance, the cerebellar cortex is highly heterogeneous in terms of structure, genetics and physiology. Purkinje cells (PCs), the principal and sole output neurons of the cerebellar cortex, can be categorized into multiple populations that differentially express molecular markers and display distinctive physiological features. Such features include action potential rate, but also their propensity for synaptic and intrinsic plasticity. However, the precise molecular and genetic factors that correlate with the differential physiological properties of PCs remain elusive. In this article, we provide a detailed overview of the cellular mechanisms that regulate PC activity and plasticity. We further perform a pathway analysis to highlight how molecular characteristics of specific PC populations may influence their physiology and plasticity mechanisms.

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Cross-species single-cell spatial transcriptomic atlases of the cerebellar cortex

Hao,

Zhu,

Huang

et al. 2024

Science

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The molecular and cellular organization of the primate cerebellum remains poorly characterized. We obtained single-cell spatial transcriptomic atlases of macaque, marmoset, and mouse cerebella and identified primate-specific cell subtypes, including Purkinje cells and molecular-layer interneurons, that show different expression of the glutamate ionotropic receptor Delta type subunit 2 ( GRID2 ) gene. Distinct gene expression profiles were found in anterior, posterior, and vestibular regions in all species, whereas region-selective gene expression was predominantly observed in the granular layer of primates and in the Purkinje layer of mice. Gene expression gradients in the cerebellar cortex matched well with functional connectivity gradients revealed with awake functional magnetic resonance imaging, with more lobule-specific differences between primates and mice than between two primate species. These comprehensive atlases and comparative analyses provide the basis for understanding cerebellar evolution and function.

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Postsynaptic plasticity of Purkinje cells in mice is determined by molecular identity

Cited by 5 publications

References 29 publications

Topographic organization in the cerebellar nuclei and inferior olive in relation to cerebellar hemispheric lobules in the mouse: Distinction between crus I and neighboring lobules

Topographic organization in the cerebellar nuclei and inferior olive in relation to cerebellar hemispheric lobules in the mouse: Distinction between crus I and neighboring lobules

Plasticity mechanisms of genetically distinct Purkinje cells

Cross-species single-cell spatial transcriptomic atlases of the cerebellar cortex

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