Postsurgical sympathetic ophthalmia: retrospective analysis of a rare entity

Majumder, Parthopratim Dutta; Anthony, Eliza; George, Amala Elizabeth; Ganesh, Sudha K; Biswas, Jyotirmay

doi:10.1007/s10792-017-0759-0

Cited by 17 publications

(29 citation statements)

References 22 publications

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“…A number of ocular complications have been described in patients with SO and VKH disease. 5,11,17 Our study generally showed similar findings. The frequency of cataracts and secondary ocular hypertension showed no difference between SO and VKH disease.…”

Section: Discussionsupporting

confidence: 84%

Comparison of Clinical Features and Visual Outcome between Sympathetic Ophthalmia and Vogt–Koyanagi–Harada Disease in Chinese Patients

et al. 2019

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Section: Discussionsupporting

confidence: 84%

Comparison of Clinical Features and Visual Outcome between Sympathetic Ophthalmia and Vogt–Koyanagi–Harada Disease in Chinese Patients

et al. 2019

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“…In humans, an inflammatory chemokine was significantly increased in the aqueous humor of one eye after cataract surgery was performed in the contralateral eye . The mechanism may be similar to sympathetic ophthalmia …”

Section: Discussionmentioning

confidence: 99%

“…25 The mechanism may be similar to sympathetic ophthalmia. 26 Diabetes mellitus was the most statistically overrepresented systemic disease to affect dogs diagnosed with LU likely due to development of diabetic cataracts, phacoemulsification, and dyslipidemia. 7,18 In addition to diabetes mellitus, hypothyroidism and hyperadrenocorticism were found to be overrepresented, likely due to secondary hyperlipidemia that arises from alterations in lipid metabolism during these disease states.…”

Section: Lipemic Uveitis No Lipemic Uveitis P Valuementioning

confidence: 99%

Lipemic uveitis and its etiologies in dogs: 75 cases

Violette

Ledbetter

2019

Veterinary Ophthalmology

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Objective To describe clinical features of dogs with lipemic uveitis (LU). Animals studied Seventy‐five dogs (114 eyes) with LU. Procedures Medical records of dogs examined by the Cornell University ophthalmology service with a clinical diagnosis of LU between 2008 and 2017 were analyzed. Signalment and clinical case aspects, including concurrent ocular disease, systemic disease, and previous ophthalmic surgery, were recorded. Results Lipemic uveitis was diagnosed in 114 eyes of 75 dogs. The mean (±standard deviation) age of dogs was 9.0 years (±2.7 years). Miniature Schnauzers and Yorkshire Terriers were statistically overrepresented compared to the ophthalmology canine referral population. Lipemic flare varied in severity with loss of menace response due to markedly opaque flare seen in 15/114 eyes (13%). Two dogs developed LU after dietary indiscretion. Forty‐nine eyes (43%) had concurrent ocular disease, most commonly keratoconjunctivitis sicca, ulcerative keratitis, and cataracts. Pseudophakia was present in 75/114 eyes (66%) and LU developed within 30 days of an intraocular surgical procedure in 63/114 eyes (55%). Hypertriglyceridemia was noted in 52 dogs of the 55 dogs tested (95%). Systemic disease affected 54/75 dogs (72%), of which diabetes mellitus, hyperadrenocorticism, and hypothyroidism were overrepresented compared to the referral population. Primary hyperlipidemia was identified in 12 dogs. Lipemic uveitis resolved at first reevaluation in 92/110 eyes (84%) and recurred in 6/114 eyes (5%) after complete resolution. Conclusions Development of lipemic uveitis in dogs appears to require the combination of hyperlipidemia and uveitis. Systemic disease is commonly associated with LU in dogs.

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“… 18 However, this opinion remains controversial. 19 Current evidence and experts suggest that corticosteroids and immunomodulators, such as cyclosporine, are very effective in treating SO. 20 Prompt treatment can control SO and maintain good vision in the sympathetic eye.…”

Section: Discussionmentioning

confidence: 99%

Sympathetic ophthalmia after vitreoretinal surgery: a report of two cases

Shen

Zhang

et al. 2021

J Int Med Res

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Sympathetic ophthalmia (SO) is a panuveitis that usually occurs after trauma to one eye. We describe two cases of SO occurring after 23-gauge vitrectomy. Case 1 involved a 66-year-old woman who underwent pars plana vitrectomy (PPV) for a rhegmatogenous retinal detachment. Two months later, she presented with decreased visual acuity (VA) and bilateral uveitis. Case 2 involved a 43-year-old woman who underwent a second PPV for recurrent retinal detachment. Two months later, she presented with bilateral panuveitis. Both patients were diagnosed with SO and were treated with methylprednisolone and cyclosporine. The first patient was further treated with a dexamethasone intravitreal implant (Ozurdex®) owing to the side effects of methylprednisolone. The VA and symptoms improved significantly after treatment in both patients. Bilateral granulomatous panuveitis following PPV should alert surgeons to consider SO. Appropriate interventions for SO can produce positive outcomes.

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Postsurgical sympathetic ophthalmia: retrospective analysis of a rare entity

Abstract: Postsurgical SO is a rare entity, but it is a bilateral blinding disease and SO following surgical intervention can have variable presentations. Rapid, effective management of postsurgical sympathetic ophthalmia can give improved visual outcomes.

Cited by 17 publications

References 22 publications

Comparison of Clinical Features and Visual Outcome between Sympathetic Ophthalmia and Vogt–Koyanagi–Harada Disease in Chinese Patients

Comparison of Clinical Features and Visual Outcome between Sympathetic Ophthalmia and Vogt–Koyanagi–Harada Disease in Chinese Patients

Lipemic uveitis and its etiologies in dogs: 75 cases

Sympathetic ophthalmia after vitreoretinal surgery: a report of two cases

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