“…This mosaic-based vaccine consists of a combination of adenovirus type 26 (Ad26) vectors expressing the globally relevant group M bivalent mosaic Env/Gag/Pol antigens and a protein-based vaccine component that contains trimeric HIV gp140 soluble proteins. The incidence of VISR reported in HIV vaccine studies has ranged widely from 0.4% to >95% across vaccine developers, depending on the type of serological test used, participant characteristics, and vaccine design, potency, durability, and dosing ( 7 , 9 , 11 – 13 ). The duration of VISR also varies, with antibodies lasting >20 years in some cases ( 14 ).…”