Poststroke Hip Fracture: Prevalence, Clinical Characteristics, Mineral-Bone Metabolism, Outcomes, and Gaps in Prevention

Fisher, Alexander A.; Srikusalanukul, Wichat; Davis, Michael W.; Smith, Paul N.

doi:10.1155/2013/641943

Cited by 20 publications

(19 citation statements)

References 189 publications

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“…Stroke patients have an increased risk of BF. [1][2][3]31 In US, compared to a non-stroke population, the hazard ratio of suffering from a hip fracture in the first 24 h after the stroke is increased by $4-fold. 7 Within the first year of hip surgery, about 4% patients will suffer from stroke.…”

Section: Discussionmentioning

confidence: 99%

Fracture shortly before stroke in mice leads to hippocampus inflammation and long-lasting memory dysfunction

Wei

Lyu

et al. 2019

J Cereb Blood Flow Metab

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Cognitive impairment occurs in stroke and hip fracture patients. In mice, bone fracture (BF) exacerbates stroke-related neuronal damage and sensorimotor dysfunction. We hypothesize that BF exacerbates post-stroke cognitive impairment. Adult mice were randomly assigned into BF, stroke, BF+stroke (BF 6 h before stroke), and control (sham operated) groups. Memory function was evaluated weekly for eight weeks by Y maze test and at eight weeks post-surgeries by novel object recognition (NOR) test. The neuronal damage and inflammation in hippocampus were analyzed three days and eight weeks after the surgeries. In Y maze test, BF+stroke mice started making fewer alternations than controls two weeks after the surgeries. Significant difference between BF+stroke and stroke groups started at five weeks post-injury and continued to the end of the experiment. In NOR test, BF+stroke group spent less time on novel objective than that of other groups. Cx3cr1+ cells and CD68+ cells accumulated in the stratum lacunosum moleculare (SLM) on the ipsilateral side of stroke injury in stroke and BF+stroke mice. BF+stroke mice had a higher ratio of ipsilateral/contralateral Cx3cr1+ cell-density than that of stroke mice. Therefore, BF shortly before stroke exacerbates hippocampal inflammation and causes long-lasting memory dysfunction.

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Section: Discussionmentioning

confidence: 99%

Fracture shortly before stroke in mice leads to hippocampus inflammation and long-lasting memory dysfunction

Wei

Lyu

et al. 2019

J Cereb Blood Flow Metab

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“…Osteoporosis, which is a systemic metabolic bone disease that can have multiple causes, is characterised by a progressive loss of bone mass and microarchitecture resulting in a high fracture risk 9 10. In Taiwan, there are approximately 500 000 people aged over 65 years old diagnosed with osteoporosis, and 25% of them have experienced a spine or hip fracture 11.…”

Section: Introductionmentioning

confidence: 99%

Stroke and osteoporosis: a Taiwan cohort study

Zhang

et al. 2020

Postgraduate Medical Journal

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BackgroundOsteoporosis and stroke are major health problems that have potentially overlapping pathophysiological mechanisms. The aim of this study was to estimate osteoporosis risk in Taiwan patientswho had a stroke.MethodThis study retrieved data contained in the Taiwan National Health Insurance Research Database for a population-based sample of consecutive patients either hospitalised for stroke or treated for stroke on an outpatient basis. A total of 7550 newly diagnosed patientswho had a stroke were enrolled during 1996–2010. Osteoporosis risk in these patients was then compared with a matched group of patients who had not had a stroke randomly selected from the database at a ratio of 1:4 (n=30 200). The relationship between stroke history and osteoporosis risk was estimated with Cox proportional hazard regression models.ResultsDuring the follow-up period, osteoporosis developed in 1537 patients who had a stroke and in 5830 patients who had not had a stroke. The incidence of osteoporosis for cohorts with and without stroke was 32.97 and 14.28 per 1000 person-years, respectively. After controlling for covariates, the overall risk of osteoporosis was 1.82-fold higher in the stroke group than in the non-stroke group. The relative osteoporosis risk contributed by stroke had apparently greater impact among male gender and younger age groups.ConclusionHistory of stroke is a risk factor for osteoporosis in Taiwan. Much attention to stroke-targeted treatment modalities might minimise adverse outcomes of osteoporosis.

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“…Of note, Australian cost estimates per HF patient appear to be consistent with international reports, which considered hospitalization costs between $US 8,358 and $US 32,195 140 and average cost in the first year following a HF Canadian $46,664. 147 The reported results and projections highlight the need of strategies to prevent post-stroke HF 148 and may have a potential of contributing to healthcare planning and resourcing for the elderly, in whom both HF and stroke remain major public health problems.…”

Section: 54mentioning

confidence: 94%

Hip Fracture After Stroke in the Elderly: Trends in the Beginning of the 21st Century and Projections into the Future in Australia

2014

Clinical Medicine Insights: Geriatrics

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AIMS:To estimate age-and sex-specific incidence rates and time trends of post-stroke hip fracture (HF) in the Australian Capital Territory (ACT) and to present projections of future post-stroke HF incidence in Australia until 2051. METHODS: Analysis of annual age-and sex-specific standardized (to 2006 Australian population) post-stroke HF incidence rates in older stroke survivors (aged 60 years) over an 11 year period (between 1999/2000 and 2009/2010). Projections of number of post-stroke HF in 2021 and 2051 are based on demographic predictors obtained from the Australian Bureau of Statistics. RESULTS: Over the study period among 1784 stroke survivors HF was recorded in 61 (3.42%) subjects (40 women and 21 men), indicating a HF incidence rate of 6.31 per 1000 stroke person-years. The standardized annual post-stroke HF incidence rate (per 100,000 person-years) in women was 1.7 times higher than in men (18.9 vs. 11.1 per, p = 0.008), and in the oldest group (80 years) compared to aged 60-69 years was 10 times higher for women (47.54 vs. 4.73) and 4 times higher for men (26.65 vs. 6.50). Post-stroke HF occurred on average within the first 2.3 years, about 2 times more often in women aged 75 years (p = 0.033) and in survivors after an ischaemic stroke (p = 0.052), but age per se did not affect the time to HF. During the 11-year period the incidence rates of post-stroke HF decreased annually in total by 17.9%. CONCLUSIONS: Post-stroke HF is relatively common, prevalent in women and occurs on average within 2.3 years after the stroke. The incidence of post-stroke HF in elderly people is decreasing. However, because of population ageing and increasing number of stroke survivors, the absolute number of post-stroke patients sustaining a HF and their proportion among the total HF population could be expected to increase.

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Poststroke Hip Fracture: Prevalence, Clinical Characteristics, Mineral-Bone Metabolism, Outcomes, and Gaps in Prevention

Cited by 20 publications

References 189 publications

Fracture shortly before stroke in mice leads to hippocampus inflammation and long-lasting memory dysfunction

Fracture shortly before stroke in mice leads to hippocampus inflammation and long-lasting memory dysfunction

Stroke and osteoporosis: a Taiwan cohort study

Hip Fracture After Stroke in the Elderly: Trends in the Beginning of the 21st Century and Projections into the Future in Australia

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