Background
To track mortality and rehospitalizations over 5 years post-stroke in a stroke cohort (SC) and compare long-term risks of complications to a matched non-stroke cohort (NSC).
Methods
A cohort design with a matched NSC comparison was used. The SC constituted a validated database of acute ischemic stroke patients, 65 years or older, hospitalized across 19 Minnesota hospitals in the year 2000. The NSC was constructed from the year 2000 General Medicare Population by matching SC members on age, race and sex. Both cohorts were tracked across 5 years of Medicare claims data to identify dates and causes of rehospitalization and death dates. Kaplan-Meier survival curves estimated cumulative incidence rates. Cox models calculated adjusted hazard ratios (HR).
Results
Event rates and adjusted HR were: Mortality: 1 year SC=24%, NSC=4%; 5 years SC=49%, NSC= 24%; HR: 4.4 (95% confidence intervals (CI) 3.6-5.5). Overall rehospitalization rates: 1 year SC=49%, NSC=20%; 5 years SC=83%; NSC=63%; HR: 2.6 (95% CI 2.2-3.0). Cause specific 5-year rehospitalization rates were significantly higher in SC versus NSC for recurrent ischemic stroke, heart failure, cardiac events, any vascular events, pneumonia, and hip fractures. The excess risk of mortality and rehospitalizations in the SC persisted beyond the initial aftermath of the acute stroke (i.e. beyond 30 days post-stroke) and persisted even after 1 year post-stroke. Average acute care Medicare charges in SC more than doubled those in NSC.
Conclusions
The high rates of acute care post-stroke readmissions indicate a need for trials to prevent long-term complications in stroke survivors.