2013
DOI: 10.1101/cshperspect.a012633
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Postreplicative Mismatch Repair

Abstract: The mismatch repair (MMR) system detects non-Watson -Crick base pairs and strand misalignments arising during DNA replication and mediates their removal by catalyzing excision of the mispair-containing tract of nascent DNA and its error-free resynthesis. In this way, MMR improves the fidelity of replication by several orders of magnitude. It also addresses mispairs and strand misalignments arising during recombination and prevents synapses between nonidentical DNA sequences. Unsurprisingly, MMR malfunction bri… Show more

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Cited by 272 publications
(253 citation statements)
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References 178 publications
(212 reference statements)
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“…mutator phenotype | genome instability | DNA replication fidelity | DNA excision | DNA repair D NA mismatch repair (MMR) is a key pathway in DNA metabolism that acts on mispaired bases that occur in replication and recombination intermediates, and as the result of some types of chemical damage to DNA (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). MMR also plays an important role in some types of cellular DNA damage responses (11)(12)(13)(14).…”
mentioning
confidence: 99%
“…mutator phenotype | genome instability | DNA replication fidelity | DNA excision | DNA repair D NA mismatch repair (MMR) is a key pathway in DNA metabolism that acts on mispaired bases that occur in replication and recombination intermediates, and as the result of some types of chemical damage to DNA (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). MMR also plays an important role in some types of cellular DNA damage responses (11)(12)(13)(14).…”
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confidence: 99%
“…Our knowledge of the mechanism of eukaryotic MMR comes from several general lines of investigation (3)(4)(5)(6)(7)(8)(9). Studies of bacterial MMR have provided a basic mechanistic framework for comparative studies (5).…”
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confidence: 99%
“…DNA replication fidelity | genome instability | mutator phenotype | cancer | mutagenesis D NA mismatch repair (MMR) is a critical DNA repair pathway that is coupled to DNA replication in eukaryotes where it corrects misincorporation errors made during DNA replication (1)(2)(3)(4)(5)(6)(7)(8)(9). This pathway prevents mutations and acts to prevent the development of cancer (10,11).…”
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confidence: 99%
“…The newly synthesized strand containing mismatches is targeted for excision followed by highfidelity resynthesis and ligation. Nevertheless, any scheme must reconcile action at a distance (i.e., the mismatch and a strand-specific signal for excision can be far apart) (7)(8)(9). MMR in eukaryotes features two families of MMR proteins, heterodimeric homologs of bacterial MutS (MSH) or MutL (MLH).…”
mentioning
confidence: 99%