Postprocedural wound-healing efficacy following removal of dermatosis papulosa nigra lesions in an African American population: A comparison of a skin protectant ointment and a topical antibiotic

Taylor, Susan C.; Averyhart, Aisha N.; Heath, Candrice

doi:10.1016/j.jaad.2010.11.009

Cited by 16 publications

(9 citation statements)

References 22 publications

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“…They remain popular, even though emerging evidence has shown that the benefit of this wholesale application of antibiotic ointments may not be necessary and the only real indication for topical antibiotics is a clinically infected wound, such as purulent drainage, erythema, warmth, pain, tenderness, or induration [29]. Numerous recent studies have echoed this sentiment, with routine administration of antibiotic ointment leading to no better outcomes but often resulting in patient discomfort, along with the possibility of antibiotic resistance and contact dermatitis [30, 31]. This is in conflict with a few earlier studies where children with minor scratches and insect bites had reduced rates of infection with topical antibiotic ointment [32, 33], although this cannot be clearly generalized to all patients.…”

Section: Wound Infectionsmentioning

confidence: 99%

Chronic Wound Healing: A Review of Current Management and Treatments

2017

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Wound healing is a complex, highly regulated process that is critical in maintaining the barrier function of skin. With numerous disease processes, the cascade of events involved in wound healing can be affected, resulting in chronic, non-healing wounds that subject the patient to significant discomfort and distress while draining the medical system of an enormous amount of resources. The healing of a superficial wound requires many factors to work in concert, and wound dressings and treatments have evolved considerably to address possible barriers to wound healing, ranging from infection to hypoxia. Even optimally, wound tissue never reaches its pre-injured strength and multiple aberrant healing states can result in chronic non-healing wounds. This article will review wound healing physiology and discuss current approaches for treating a wound.

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Section: Wound Infectionsmentioning

confidence: 99%

Chronic Wound Healing: A Review of Current Management and Treatments

2017

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“…Out of the 12 included studies, we concluded 2 were at high risk of bias, 11 , 20 4 were at unclear risk, 13 , 14 , 17 , 22 and 6 were at low risk. 12 , 15 , 16 , 18 , 19 , 21 We found detailed descriptions were lacking for random sequence generation and/or allocation concealment in four studies that were considered at unclear risk.…”

Section: Resultsmentioning

confidence: 92%

A systematic review and meta-analysis on the use of prophylactic topical antibiotics for the prevention of uncomplicated wound infections

Tong

Hammer

Johnson

et al. 2018

IDR

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BackgroundThe prescription of topical antibiotics for the prevention of infections in uncomplicated wounds is common. However, the efficacy is not well reported. Therefore, the objective of the study was to conduct a systematic review and meta-analysis of the available evidence on prevention of uncomplicated wound infections by prophylactic topical antibiotics.Materials and methodsThe search included Pubmed, Google Scholar, SCOPUS, Embase, Cochrane, ClinicalTrials.gov, International Clinical Trials Registry Platform, National Technical Information Service, and the National Guidelines Clearinghouse.ResultsWe identified eight randomized controlled trials and four quasi-randomized trials that met the criteria for the systematic review. Of these trials, 11 studies were pooled for meta-analysis to compare the effects of topical antibiotics versus placebo and 4 studies were pooled for comparison of effects of topical antibiotics versus topical antiseptics on uncomplicated wounds. Fewer wound infections occurred in the topical antibiotic arms compared to placebo (pooled risk ratio: 0.57 [95% CI: 0.37 to 0.86]; p=0.01 and pooled risk difference: −3.1% [95% CI: −5.8% to −0.34%]; p=0.03). Compared to antiseptics, topical antibiotics demonstrated statistically significant relative risk reduction (pooled risk ratio: 0.56 [95% CI: 0.23 to 0.91]; p=0.02), while there was no significant absolute risk reduction (pooled risk difference: −3.7% [95% CI: −7.9% to +0.6%]; p=0.09).ConclusionTopical antibiotics are effective in reducing wound infections after surgical procedures, but the absolute benefit is small. Given the global emergence of antimicrobial resistance, judicious use of antibiotics is encouraged and use of antiseptics should be considered as a reasonable alternative to topical antibiotics.

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“…DPN histologically appears to be a variant of seborrheic keratosis. [ 3 ] DPN occurs in individuals with darker skin types. DPN is seen more frequently in African Americans and Africans.…”

Section: Discussionmentioning

confidence: 99%

“…DPN is seen more frequently in African Americans and Africans. [ 3 ] DPN is rarely seen in Caucasians. Our patient had Fitzpatrick skin type-2.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of the pulse dye laser treatment in a caucasian women with dermatosis papulosa nigra

et al. 2015

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Dermatosis papulosa nigra (DPN) is a group of superficial, benign papules commonly in African-American and Asian persons. DPN is considered to be a form of seborrheic keratosis with a specific localization and it is less frequently described in the white population. Treatment modalities include cryosurgery, curettage, electrosurgery, shave removal, and different laser treatment. Pulsed dye laser (PDL) has traditionally been used to treat vascular lesions, but it has been shown to be effective in treatment of lentigines, ephelides, seborrheic keratosis, and rarely DPN. A 43-year-old white female presents with a 5 year-old history of hyperpigmented papules on malar region, neck and upper trunk. The patient is diagnosed with DPN based on her clinical and histopathological findings. The PDL treatment was used successfully. In our opinion PDL is an effective alternative cure option for DPN.

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Postprocedural wound-healing efficacy following removal of dermatosis papulosa nigra lesions in an African American population: A comparison of a skin protectant ointment and a topical antibiotic

Cited by 16 publications

References 22 publications

Chronic Wound Healing: A Review of Current Management and Treatments

Chronic Wound Healing: A Review of Current Management and Treatments

A systematic review and meta-analysis on the use of prophylactic topical antibiotics for the prevention of uncomplicated wound infections

Effectiveness of the pulse dye laser treatment in a caucasian women with dermatosis papulosa nigra

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