Postprocedural endophthalmitis: a review

Levison, Ashleigh L.; Mendes, Thais Sousa; Bhisitkul, Robert B.

doi:10.1586/eop.12.77

Cited by 11 publications

(4 citation statements)

References 155 publications

(225 reference statements)

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“…However, the earlier presentation could not be attributed to an increased incidence of Streptococcus spp. infection reported in some studies and may reflect the increased ability of inoculated organisms to multiply in the vitreous compared to the anterior chamber [ 29 ].…”

Section: Causative Organismsmentioning

confidence: 99%

Endophthalmitis: Changes in Presentation, Management and the Role of Early Vitrectomy

Shao

Yates

et al. 2021

Ophthalmol Ther

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Endophthalmitis is a sight-threatening condition, and its timely and appropriate management is essential in preventing permanent vision loss. Recent changes in clinical practice in endophthalmitis and advances in modern vitreoretinal surgery may limit the applicability of established randomised clinical trial evidence to current management. This review discusses the epidemiology, pathophysiology, changing patient presentation, diagnosis and advances in the management of endophthalmitis, presenting the existing literature on this topic and results from Sydney Eye Hospital.

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Section: Causative Organismsmentioning

confidence: 99%

Endophthalmitis: Changes in Presentation, Management and the Role of Early Vitrectomy

Shao

Yates

et al. 2021

Ophthalmol Ther

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“…The incidence rate of infectious endophthalmitis after intravitreal injection is low when compared to other post-surgical infectious endophthalmitis, it varies between 0.038% and 0.053% [36].…”

Section: Endophthalmitis Post-intravitreal Injectionsmentioning

confidence: 85%

Infectious Endophthalmitis: Ongoing Challenges and New Prospectives

Abri¹,

Al-Hinai²,

Al-Fadhil³

2023

Eye Diseases - Recent Advances, New Perspectives and Therapeutic Options

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Endophthalmitis is a rare but potentially sight and organ-threatening ocular emergency characterized by marked intraocular inflammation. It can be categorized into two broad categories of exogenous and endogenous types. Exogenous endophthalmitis is caused by inoculation of the globe by either bacterial or fungal microorganisms from an external environment and most commonly occurs as a complication of intraocular surgeries or procedures and open globe injuries. Blurred vision and pain are the main symptoms, and gram-positive coagulase-negative organisms are the main etiology of exogenous endophthalmitis. Endogenous endophthalmitis is caused by the hematogenous spread of microorganisms from distant sites of the body into the globe. Both categories lead to subsequent intraocular inflammation and potentially severe visual and anatomical devastating consequences. In addition, they have different risk factors and causative microorganisms, and thus, require somehow different diagnostic and treatment approaches. In this review chapter, further review of infectious endophthalmitis in terms of risk factors, causative pathogens, clinical presentations, prognosis, prevention, and the latest therapeutic recommendations are discussed.

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“…Hospital stays were shortened, and eventually the surgery became an outpatient procedure. Initially, the introduction of phacoemulsification and sutureless clear corneal incisions led to an increase in endophthalmitis rates, from 0.074% to 0.087% up to 0.0189–0.265%, which was thought to be due to increased microbial access to the anterior chamber after completion of the surgery [ 17 ]. The clear corneal incision, however, remains the favored approach for cataract extraction (compared to the scleral tunnel incision) since it has led to faster visual recovery, shorter surgical times, and less manipulation of the globe.…”

Section: Evolution Of Cataract Surgerymentioning

confidence: 99%

The Routine Use of Intracameral Antibiotics to Prevent Endophthalmitis After Cataract Surgery: How Good is the Evidence?

George

Stewart

2018

Ophthalmol Ther

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Post-operative endophthalmitis (POE) following cataract surgery is an uncommon, vision-threatening complication that has been reported to occur at rates of between approximately 0.03% and 0.2%. Prompt diagnosis and treatment of endophthalmitis is critical for minimizing vision loss, but most recent efforts have focused on the prophylactic administration of antibiotics to prevent the development of endophthalmitis. Surgeons from around the world have different topical and intracameral antibiotic usage patterns to prevent endophthalmitis, and to date no general consensus regarding best practice has emerged. Several studies have reported on the routine use of intracameral cefuroxime, moxifloxacin, and vancomycin, including a single randomized clinical trial by the European Society of Cataract and Refractive Surgery (ESCRS) in 2007. These studies have notable shortcomings, but many authors suggest that intracameral cefuroxime together with topical antibiotics probably decreases the risk of endophthalmitis. However, the deleterious effects of routine prophylactic antibiotics, which include toxicity, cost, and increasing antimicrobial resistance, among others, are noteworthy. In contrast, aseptic technique with pre-operative instillation of povidone-iodine remains the only technique supported by level I evidence to reduce the incidence of endophthalmitis. Although the routine use of intracameral antibiotics continues to increase throughout the world, data from multicenter, randomized, prospective trials is needed to provide better guidance regarding the prophylactic use of antibiotics.

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Postprocedural endophthalmitis: a review

Cited by 11 publications

References 155 publications

Endophthalmitis: Changes in Presentation, Management and the Role of Early Vitrectomy

Endophthalmitis: Changes in Presentation, Management and the Role of Early Vitrectomy

Infectious Endophthalmitis: Ongoing Challenges and New Prospectives

The Routine Use of Intracameral Antibiotics to Prevent Endophthalmitis After Cataract Surgery: How Good is the Evidence?

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