Postprandial hyperglycemia is associated with an increase in cardiovascular disease risk. Therefore, it is important to prevent postprandial hyperglycemia. Both daily diet and exercise are important factors to control postprandial hyperglycemia. The short-term intake of a high-fat diet worsens postprandial glucose metabolism. Although a single bout of exercise can improve postprandial glucose metabolism, a single bout of moderate-continuous exercise has less effect on the impact of the short-term intake of a high-fat diet on postprandial glucose metabolism, probably because this type of intake impairs the effect of a single bout of moderatecontinuous exercise. Further studies are required to determine the exercise regimen that effectively ameliorates the worsening of postprandial glucose metabolism.