Postprandial VLDL-TG metabolism in type 2 diabetes

Søndergaard, Esben; Johansen, Rakel Fuglsang; Jensen, Michael D.; Nielsén, Sören

doi:10.1016/j.metabol.2017.07.002

Cited by 18 publications

(15 citation statements)

References 46 publications

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“…Nielsen et al assessed VLDL kinetics in male type 2 diabetes patients and healthy controls [59▪,60,61]. In contrast to prior studies, the two groups were matched for body mass index.…”

Section: Impact Of Diabetes On Lipoprotein Metabolismmentioning

confidence: 99%

“…In contrast to prior studies, the two groups were matched for body mass index. Surprisingly, VLDL-triglyceride secretion, clearance, and oxidation were the same between the two groups [59▪,60]. The effects of insulin or a mixed meal to suppress VLDL-triglyceride secretion were also comparable.…”

Section: Impact Of Diabetes On Lipoprotein Metabolismmentioning

confidence: 99%

“…The effects of insulin or a mixed meal to suppress VLDL-triglyceride secretion were also comparable. Moreover, there were no differences in the ability of VLDL-triglyceride to be stored in adipose tissue [60]. These findings suggest that VLDL-triglyceride kinetics may be affected more strongly by obesity or insulin resistance than by diabetes per se.…”

Section: Impact Of Diabetes On Lipoprotein Metabolismmentioning

confidence: 99%

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Unexplained reciprocal regulation of diabetes and lipoproteins

Higuchi

Izquierdo

Haeusler

2018

Current Opinion in Lipidology

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Purpose of review Type 2 diabetes is associated with a characteristic dyslipidemia that may exacerbate cardiovascular risk. The causes of, and the effects of new antihyperglycemia medications on, this dyslipidemia, are under investigation. In an unexpected reciprocal manner, lowering LDL-cholesterol with statins slightly increases the risk of diabetes. Here we review the latest findings. Recent findings The inverse relationship between LDL-cholesterol and diabetes has now been confirmed by multiple lines of evidence. This includes clinical trials, genetic instruments using aggregate single nucleotide polymorphisms, as well as at least eight individual genes – HMGCR, NPC1L1, HNF4A, GCKR, APOE, PCKS9, TM6SF2, and PNPLA3 – support this inverse association. Genetic and pharmacologic evidence suggest that HDLcholesterol may also be inversely associated with diabetes risk. Regarding the effects of diabetes on lipoproteins, new evidence suggests that insulin resistance but not diabetes per se may explain impaired secretion and clearance of VLDL-triglycerides. Weight loss, bariatric surgery, and incretin-based therapies all lower triglycerides, whereas SGLT2 inhibitors may slightly increase HDL-cholesterol and LDL-cholesterol. Summary Diabetes and lipoproteins are highly interregulated. Further research is expected to uncover new mechanisms governing the metabolism of glucose, fat, and cholesterol. This topic has important implications for treating type 2 diabetes and cardiovascular disease.

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“…Nielsen et al assessed VLDL kinetics in male type 2 diabetes patients and healthy controls [59▪,60,61]. In contrast to prior studies, the two groups were matched for body mass index.…”

Section: Impact Of Diabetes On Lipoprotein Metabolismmentioning

confidence: 99%

Section: Impact Of Diabetes On Lipoprotein Metabolismmentioning

confidence: 99%

Section: Impact Of Diabetes On Lipoprotein Metabolismmentioning

confidence: 99%

See 1 more Smart Citation

Unexplained reciprocal regulation of diabetes and lipoproteins

Higuchi

Izquierdo

Haeusler

2018

Current Opinion in Lipidology

View full text Add to dashboard Cite

show abstract

“…Such research is fundamental to substantiate personalized nutritional approaches. For example, postprandial lipaemia (hypertriglyceridemia) from a high fat meal, known to worsen in individuals with type 2 diabetes, is associated with cardiovascular disease risk and acute cardiovascular events . Postprandial lipaemia can be lowered with higher intake of dietary fiber, polyphenols, medium chain fatty acids, and long‐chain n‐3 polyunsaturated fatty acids .…”

Section: Introductionmentioning

confidence: 99%

Vegan and Animal Meal Composition and Timing Influence Glucose and Lipid Related Postprandial Metabolic Profiles

Draper

Tini

Vassallo³

et al. 2019

Molecular Nutrition Food Res

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Scope Flexitarian dieting is increasingly associated with health benefits. The study of postprandial metabolic response to vegan and animal diets is essential to decipher how specific diet components may mediate metabolic changes. Methods and results A randomized, crossover, controlled vegan versus animal diet challenge is conducted on 21 healthy participants. Postprandial metabolic measurements are conducted at seven timepoints. Area under the curve analysis of the vegan diet response demonstrates higher glucose (EE 0.35), insulin (EE 0.38), triglycerides (EE 0.72), and nine amino acids at breakfast (EE 4.72–209.32); and six lower health‐promoting fatty acids at lunch (EE −0.1035 to −0.13) (p < 0.05). Conclusions Glycemic and lipid parameters vary irrespective of diet type, demonstrating that vegan and animal meals contain health‐promoting and suboptimal nutrient combinations. The vegan breakfast produces the same pattern of elevated branched chain amino acids, insulin, and glucose as the animal diet from the fasting results, reflecting the low protein load in the animal and the higher branched‐chain amino acid load of the vegan breakfast. Liberalization of the vegan menu to vegetarian and the animal menu to a Nordic‐based diet can result in optimal metabolic signatures for both flexitarian diet strategies in future research.

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“…Many studies have shown that hypertriglyceridaemia plays an important role in the development of premature atherosclerosis . Disturbances in triglyceride (TG) metabolism are characterised by postprandial accumulation of TG‐rich lipoprotein remnants and have been observed in various populations with elevated cardiovascular (CV) risk . In individuals without diabetes mellitus (DM), abnormal postprandial hypertriglyceridaemia can increase plasma glucagon levels, leading to insufficient insulin‐ and glucose‐induced glucagon suppression .…”

Section: Introductionmentioning

confidence: 99%

The influence of gene polymorphisms on postprandial triglyceride response after oral fat tolerance test meal in patients with diabetes mellitus

et al. 2019

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Summary Aims We evaluated the influence of CETP (rs5882 and rs708272), APOE (rs7412, rs429358) and LPL (rs328) gene polymorphisms on triglyceride (TG) response to oral fat tolerance test (OFTT) meal in patients with well‐controlled type 2 diabetes mellitus (T2DM). Methods Fifty‐one men underwent OFTT and according to postprandial TG response patients were divided into two subgroups (positive [TG ≥ 220 mg/dL, 31 patients] and negative [TG < 220 mg/dL, 20 patients]). All patients were genotyped, and study variants were detected using polymerase chain reaction (PCR) and restricted fragment length polymorphism (RFLP) analysis. Results Patients with genotype SS of LPL gene compared with genotype SX had more frequently positive response to OFTT (P = .04) and lower high‐density lipoprotein cholesterol (HDL‐C) concentration (P = .03). Patients with positive response to OFTT and genotype SS of LPL gene compared with genotype SX had lower AUC (area under the curve)‐TG, 1744 (368) vs 1887 (807) mg/dL/h, respectively, P = .04. CETP and APOE gene polymorphisms had no influence on postprandial TG response to OFTT. Conclusions In patients with well‐controlled T2DM, LPL but not CETP and APOE gene polymorphisms influenced TG postprandial response. Particularly, S447 allele carriers of LPL gene presented more frequently positive postprandial TG response to OFTT compared with 447X allele carriers. No differences were found between allele carriers of patients with negative response to OFTT in any other studied gene polymorphism.

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Postprandial VLDL-TG metabolism in type 2 diabetes

Cited by 18 publications

References 46 publications

Unexplained reciprocal regulation of diabetes and lipoproteins

Unexplained reciprocal regulation of diabetes and lipoproteins

Vegan and Animal Meal Composition and Timing Influence Glucose and Lipid Related Postprandial Metabolic Profiles

The influence of gene polymorphisms on postprandial triglyceride response after oral fat tolerance test meal in patients with diabetes mellitus

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