Postprandial transduodenal bolus transport is regulated by complex peristaltic sequence

Abstract

Combined impedancometry and manometry improves the analysis of the peristaltic patterns that are associated with postprandial transduodenal chyme transport. Postprandial transduodenal bolus transport is regulated by propulsive peristaltic patterns, which are frequently complex but well organized. This finding should be taken into consideration in the analysis of intestinal motility studies.

Changes in Morphology and Function in Small Intestinal Mucosa After Roux-en-Y Surgery in a Rat Model

“…Interestingly, both the mitogenic and differentiating properties of repetitive deformation appear independent of the effects of glutamine (27). Luminal nutrients stimulate both peristalsis (28) and villous motility (29). Moreover, as the luminal contents are relatively non-compressible, passage of luminal contents through the bowel deforms the villi and the mucosa by a combination of pressure and shear stress.…”

Computer modeling of digestive processes in the alimentary tract and their physiological regulation mechanisms: closing the gap between digestion models and in vivo behavior

“…Valeriy Poroyko, Laboratory Corporation of America Holdings (LabCorp), United States Focusing on food digestion in humans, much understanding of the mechanical, enzymatic, and fermentative breakdown of food materials has been obtained from in vivo studies, analyzing the behavior of separate digestive organs (mouth, stomach, small intestine, and large intestine), by tracking the motility, digestive fluid release, and progression of digestion through imaging and sampling techniques (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) in healthy and diseased states and from studies on animals. These studies have been supplemented by a large number of in vitro and ex vivo digestion studies, using laboratory setups in which enzymes, microbes, or simulated secretions from digestive glands have been added to food material (13, 14), and cell biological studies (15)(16)(17).…”

“…In the fed state, the phasic contractions result in rhythmic waves that generally progress distally, through neural coupling between excitators of contraction, producing peristaltic waves that mix and grind the luminal content and propel this content distally ( 10 ), in this way distributing the nutrients and actives toward the absorptive surfaces of the small intestine and through the colon. The precise progression of peristaltic waves is however complex ( 6 , 8 ), and state of feeding, individual differences, and various diseases ( 2 ), including psychological stress, lead to large differences in these motility patterns ( 3–5 , 7 , 12 , 34 ).…”