Postprandial silent ischaemia following a fatty meal in patients with recently diagnosed coronary artery disease

Abstract

Silent myocardial ischaemia (SI) is recognised as an important prognostic factor in patients with coronary artery disease (CAD). Postprandial angina is related to severity of CAD. The effect of postprandial metabolic changes in the pathogenesis of SI is unclear. We studied the postprandial changes in glucose, insulin and triglyceride, and non-esterified fatty acids (NEFA) in relation to postprandial SI and exercise capacity, in patients with CAD. Forty elderly volunteers (63 ؎ 1 years) mean age ؎ s.e.m., with a history of angina were selected on the basis of a Rose questionnaire and a positive exercise stress test (modified Bruce protocol). The test meal contained 45% fat. The meal was consumed at 9.00 am and hourly blood samples were taken for glucose, insulin, triglyceride and NEFA. Continuous Holter monitoring for SI was conducted using a Space-

The effects of GLP-1 based therapies on postprandial haemodynamics: Two randomised, placebo-controlled trials in overweight type 2 diabetes patients

“…As such, although exenatide has no acute effect on PPH, and might not reduce symptoms as dizziness and syncope, the improvement in postprandial DBP could hypothetically be beneficial in patients with (a high risk of) postprandial myocardial ischemia. Since postprandial myocardial ischemia is a frequently occurring and asymptomatic risk factor for cardiac events [19], more studies are needed to fully comprehend the effects of exenatide on postprandial myocardial perfusion.…”