Postprandial Serum Bile Acid for the Detection of Hepatobiliary Disease

Kaplowitz, Neil

doi:10.1001/jama.1973.03220300048011

Cited by 157 publications

(14 citation statements)

References 4 publications

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“…After shunt surgery, AI. C.'s fasting levels of bile acids wxere slightly elevated (2..7 ,ug/ml) and rose postprandially to 17.6 Ag,/ml, a value that is higher than that previously reported for subjects with chronic cirrhosis (38). This elevation is presumably due to the postprandial shunting of bile acid-rich portal blood into the systemic circulatioin.…”

Section: Cholesterol and Lipoprotein Synthesis In Familial Hypercholementioning

confidence: 59%

Reduction in cholesterol and low density lipoprotein synthesis after portacaval shunt surgery in a patient with homozygous familial hypercholesterolemia.

Bilheimer

Goldstein²,

Grundy³

et al. 1975

J. Clin. Invest.

237

102

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Section: Cholesterol and Lipoprotein Synthesis In Familial Hypercholementioning

confidence: 59%

Reduction in cholesterol and low density lipoprotein synthesis after portacaval shunt surgery in a patient with homozygous familial hypercholesterolemia.

Bilheimer

Goldstein²,

Grundy³

et al. 1975

J. Clin. Invest.

237

102

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“…Mild or moderate hepatic lipidosis may result in changes in liver function that are not accompanied by hepatocyte destruction and increases in liver-specific serum enzyme activities. 14*' [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] This study was designed to evaluate SBA measurements as indicators of hepatic fatty infiltration in dairy cattle. Concentrations of SBA were measured in clinically healthy, high-producing dairy cattle and compared with BSP T 4 and hepatic fat content.…”

mentioning

confidence: 99%

Serum Bile Acid Concentrations in Dairy Cattle With Hepatic Lipidosis

Garry

Fettman

Curtis

et al. 1994

Veterinary Internal Medicne

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This study was designed to evaluate serum bile acid measurements as indicatory, of liver function and/or hepatic fat infiltration in dairy cattle. Serum bile acid concentrations were measured in healthy dairy cattle at different stages of lactation after fasting or feeding. Bile acid concentrations were compared with liver fat content and sulfobromophthalein (BSP) half‐life (T 1/2). Serum bile acid concentrations were higher in cows in early lactation and with higher daily milk production. Compared with prefasting values, bile acid concentrations were decreased at 8,14, and 24 hours of fasting. Blood samples from fed cows at 1 ‐ to 2‐hour intervals had wide and inconsistent variations in bile acid concentration. Because serum bile acids correlated well with BSP T 1/2, it is suggested that both measurements evaluate a similar aspect of liver function. Neither bile acids nor BSP T I correlated with differences in liver fat content among cows. Because of large variability in serum bile acid concentrations in fed cows and the lack of correlation of measured values with liver fat content, bile acid determinations do not appear useful for showing changes in hepatic function in fed cows with subclinical hepatic lipidosis nor serve as a screening test for this condition.

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“…Since the initial observation of a postpran dial rise in serum bile salt concentration in patients with liver disease [1] it has been claimed that the measurement of bile salt concentration in a serum sample, taken 2 h after a fat-containing meal, provides a sensi tive index ofliver function [1][2][3]. Improved methodology has increased the sensitivity of bile salt measurements and has allowed the detection of a postprandial rise in serum bile salt concentrations in normal subjects [4][5][6][7][8][9][10].…”

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confidence: 99%

Differential Timing of Maximal Postprandial Concentrations of Plasma Chenodeoxycholate and Cholate: Its Variability and Implications

et al. 1981

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The concentrations of conjugated chenodeoxycholate and cholate in serum have been measured in 26 controls and 19 patients with liver disease before and after taking a fat-containing meal. The times at which maximum bile salt concentrations occurred varied considerably between individuals. In the majority of cases maximal concentrations of the two bile salts occurred simultaneously but in 13 subjects maximal concentrations of chenodeoxycholate were found 15–60 min prior to maximal cholate concentrations. The measurement of bile salt concentration in a single sample taken 2 h after the fatty test meal would have produced two false-negative results in the patients with liver disease. It is concluded that the jejunal absorption of dihydroxylated bile salts may not be significant in the majority of individuals and that the protocol for assessment of liver function by postprandial bile salt analysis should include at least two blood samples collected at 1.5 and 2 h after ingestion of the test meal.

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Postprandial Serum Bile Acid for the Detection of Hepatobiliary Disease

Cited by 157 publications

References 4 publications

Reduction in cholesterol and low density lipoprotein synthesis after portacaval shunt surgery in a patient with homozygous familial hypercholesterolemia.

Reduction in cholesterol and low density lipoprotein synthesis after portacaval shunt surgery in a patient with homozygous familial hypercholesterolemia.

Serum Bile Acid Concentrations in Dairy Cattle With Hepatic Lipidosis

Differential Timing of Maximal Postprandial Concentrations of Plasma Chenodeoxycholate and Cholate: Its Variability and Implications

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