Postprandial Nutrient Handling and Gastrointestinal Hormone Secretion After Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy

Mechanisms of Weight Loss After Sleeve Gastrectomy and Adjustable Gastric Banding: Far More Than Just Restriction

“…Peterli and his colleagues assessed patients treated by SG and found postoperatively higher postprandial CCK concentrations than preoperative values. A similar finding was also reported by Svane et al . In another human study, Mans et al detected a higher postprandial early peak concentration of CCK in patients with morbid obesity after SG and explained that this change may be correlated with enhanced gastric emptying and rapid nutrient delivery, contributing to early satiation in patients post SG.…”

“…Secreted from enteroendocrine L cells of the gastrointestinal tract (especially the distal ileum), glucagon‐like peptide 1 (GLP‐1) is considered a satiety signal in response to meal stimulation, which promotes insulin secretion, suppresses glucagon production, improves insulin sensitivity, and inhibits intestinal transit. Previous research has shown that the gastric bariatric procedures have a significant influence on the serum fasting concentrations of GLP‐1 but that the effect varies: there has been an increase or an unchanged fasting GLP‐1 level after SG and no change or even a decrease in fasting plasma GLP‐1 levels after AGB . To date, the postprandial plasma GLP‐1 level is believed to be more important than the fasting level in regulating glucose homeostasis and food intake.…”

Glycemic effect of pancreatic preproglucagon in mouse sleeve gastrectomy

“…Whether the minor differences in HFD type and timing of exposure, the mouse models used, or some unknown factor may contribute either independently, or in combination, to the divergent results is unknown. It is also possible that a combination of factors is important in the metabolic success of VSG as has been demonstrated previously (39). Therefore, we cautiously interpret our data to say that pancreatic GLP-1 is important for postprandial glycemic excursions with VSG, but whether this signal, in and of itself, is critical for the resolution of diabetes mellitus with VSG cannot be determined from these mouse models.…”

A meta-analysis of the medium- and long-term effects of laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass

“…Ghrelin is reduced after LSG as large parts of the stomach were resected, whereas ghrelin may increase or remain stable after LRYGB [41,42]. A recent study showed that LRYGB was characterized by accelerated absorption of glucose and amino acids, whereas protein metabolism after LSG did not differ significantly from controls, suggesting that different mechanisms explain improved glycemic control and weight loss after these surgical procedures [43].…”