Postprandial metabolic fate of tocotrienol-rich vitamin E differs significantly from that of α-tocopherol

Fairus, Syed; Nor, Rosnah M; Cheng, Hwee Ming; Sundram, Kalyana

doi:10.1093/ajcn/84.4.835

Cited by 68 publications

(72 citation statements)

References 37 publications

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“…In an animal study, it was shown that enterocytes use two pathways for vitamin E absorption and that the major pathway of a-tocopherol absorption is via chylomicrons (42). Furthermore, in a human study with fat-rich meal feeding, a-tocopherol in LDL and HDL decreased postprandially, concomitantly with a rise in triglyceride-rich lipoprotein a-tocopherol in healthy subjects (43), and plasma concentration of a-tocopherol was reported to be increased at 2 h after supplementation (44). These reports support the difference of a-tocopherol/lipid concentration at 120 min after the BB meal and after the BBS meal in this study.…”

Section: Discussionmentioning

confidence: 98%

“…Furthermore, intake of anti-oxidative supplements such as a-tocopherol is reported to have a greater effect on oxidative stress in subjects with postprandial state abnormalities such as hyperglycemia and hyperlipidemia (10). However, the amounts of purified dietary fiber and antioxidant vitamins that have been studied were much larger than the usual intakes from one meal (10)(11)(12)(13)(14).…”

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confidence: 99%

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Effects of Green-Leafy Vegetable Intake on Postprandial Glycemic and Lipidemic Responses and ^|^alpha;-Tocopherol Concentration in Normal Weight and Obese Men

Maruyama

Kikuchi

Masuya

et al. 2013

J Nutr Sci Vitaminol

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Summary Vegetable consumption has been encouraged as a component of nutritional education for obese and insulin-resistant patients. However, the benefits of vegetable intake in a therapeutic diet on postprandial glycemic and lipidemic responses have not been clarified. We studied the effects of the intake of spinach, a green-leafy vegetable rich in dietary fiber and a-tocopherol, with a fat-rich meal on postprandial glycemic and lipidemic changes. Fourteen normal weight and 10 obese men consumed three test meals of bread, as a control, bread and butter, and bread and butter with boiled spinach. Blood samples were obtained prior to and 30, 60, 120, 180 and 240 min after consuming the test meals. Compared with the bread meal, consumption of the bread and butter meal showed a reduced peak glucose response at 30 min in normal (p,0.05) but not in obese subjects. The increase in triglyceride and decrease in LDL-cholesterol were greater after the butter-containing meal than after the bread meal (p,0.05). The a-tocopherol/lipid level decreased and remained low after the bread and butter meal, but the decrease was smaller with the spinach-containing meal in obese subjects (p,0.05). These results suggest that green-leafy vegetable intake with a fat-rich meal is effective for supplying postprandial a-tocopherol in obese subjects, but consumption of a regular-sized dish cannot be expected to improve abnormal postprandial hyperglycemic or hyperlipidemic responses.

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Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

Effects of Green-Leafy Vegetable Intake on Postprandial Glycemic and Lipidemic Responses and ^|^alpha;-Tocopherol Concentration in Normal Weight and Obese Men

Maruyama

Kikuchi

Masuya

et al. 2013

J Nutr Sci Vitaminol

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show abstract

“…This is the first investigation to focus on the effects of vegetable consumption on changes in postprandial PON1 levels. The consumption of vegetables 22,23) or meals supplemented with vitamins 24,25) reportedly increases the amount of lipid soluble antioxidants in postprandial TG-rich lipoproteins. Therefore, colored vegetable consumption is expected to decrease postprandial oxidative stress and increase PON1 activity by protecting PON1 enzymes from oxidative stress-induced inactivation.…”

Section: Discussionmentioning

confidence: 99%

Postprandial Paraoxonase 1 Activity Following Consumption of Recommended Amounts of Mixed Meals in Healthy Males

Kameyama

Maruyama

Kotani

et al. 2016

JAT

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Aim: Postprandial lipid level increases induce oxidative stress, which is involved in atherogenesis.The antioxidant properties of paraoxonase 1 (PON1) have attracted attention. However, changes in postprandial PON1 levels differ across prior studies, and changes in PON1 lactonase activity, potentially relevant to PON1 physiology, after the consumption of ordinary meals are unknown. Herein we evaluated postprandial serum lipid levels and PON1 changes following mixed-meal consumption of the amounts recommended for ordinary meals. Methods: Nine healthy male volunteers consumed three different meals in a randomized cross-over design. The test meals were as follows: S, white rice; SMF, S with fat-containing protein-rich main dishes; and SMFV: SMF with vegetable dishes. The serum lipid concentrations and PON1 lactonase and arylesterase activities were determined during a three-hour period after the consumption of these meals. Results: The postprandial triglyceride levels were higher after consuming the SMF and SMFV meals than after consuming the S meal. Despite postprandial high-density lipoprotein cholesterol being unchanged, PON1 lactonase activity was decreased, while PON1 arylesterase activity was increased in the postprandial state after all test meals. Postprandial changes in lactonase and arylesterase activities did not differ among the test meals. Conclusions: Inverse changes in PON1 lactonase and arylesterase activities were observed after consuming recommended ordinary meals. This observation provides useful information for choosing PON1 species as postprandial markers. J Atheroscler Thromb, 2016; 23: 225-232.

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“…To date, several acute studies with oral supplementation of palm T3 in a single dose from 200 mg to 1011 mg did not report any acute adverse event (Yap et al, 2001;Yap and Yuen, 2004;Fairus et al, 2006). Also in chronic studies, long-term supplementation of T3 ranging from one month to five years did not report any events of discomfort or toxicities in the subjects investigated (Tomeo et al, 1995;Qureshi et al, 1997;Mensink et al, 1999;Nesaretnam et al, 2010;Zaiden et al, 2010;Mahalingam et al, 2011;Yuen et al, 2011;Heng et al, 2013).…”

Section: Ramdomised (N=32) (16 Males and 16 Females)mentioning

confidence: 99%

Safety Assessment of Tocotrienol Supplementat Ion in Subjects With Metabolic Syndrome: A Randomised Control Trial

Gan¹,

Lai²,

Chew³

et al. 2016

JOPR

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Postprandial metabolic fate of tocotrienol-rich vitamin E differs significantly from that of α-tocopherol

Cited by 68 publications

References 37 publications

Effects of Green-Leafy Vegetable Intake on Postprandial Glycemic and Lipidemic Responses and ^|^alpha;-Tocopherol Concentration in Normal Weight and Obese Men

Effects of Green-Leafy Vegetable Intake on Postprandial Glycemic and Lipidemic Responses and ^|^alpha;-Tocopherol Concentration in Normal Weight and Obese Men

Postprandial Paraoxonase 1 Activity Following Consumption of Recommended Amounts of Mixed Meals in Healthy Males

Safety Assessment of Tocotrienol Supplementat Ion in Subjects With Metabolic Syndrome: A Randomised Control Trial

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