Postprandial lipemia: An under-recognized atherogenic factor in patients with diabetes mellitus

Pastromas, Sokratis; Terzi, Angela-Beth; Tousoulis, Dimitris; Koulouris, Spyridon

doi:10.1016/j.ijcard.2007.04.172

Cited by 60 publications

(48 citation statements)

References 97 publications

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“…Postprandial hyperlipidemia is a feature of common, often inter-related, metabolic diseases, including obesity, insulin resistance, the metabolic syndrome (a combination of obesity, hypertension, insulin resistance/diabetes), non alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus [12,34,81] (Fig. 1).…”

Section: Postprandial Lipemia and Metabolic Dis-easesmentioning

confidence: 99%

“…Insulin resistance, a condition commonly found across the different metabolic diseases, is believed to be the primary contributory factor to the postprandial hyperlipidemia [83]. The dyslipidemia is caused by the accumulation of TRLs in the blood due to delayed clearance of CM and CMR coupled with overproduction of these lipoproteins by the intestine and of VLDL by the liver [81,83,84].…”

Section: Postprandial Lipemia and Metabolic Dis-easesmentioning

confidence: 99%

“…In addition, it has been suggested that alterations in the production or action of glucagon-like peptide-1 and -2, which have been implicated in the regulation of CM formation, may also play a role [84]. The delayed clearance of the intestinally derived lipoproteins is believed to be caused by a reduction in the activity of LPL and hepatic lipase, increased competition for lipolysis by LPL because of the rise in VLDL levels, and decreased uptake by the liver due to lower concentrations of apoE in the particles, increased competition for receptors from VLDL and impairment by hyperglycemia [39,81,83,87].…”

Section: Postprandial Lipemia and Metabolic Dis-easesmentioning

confidence: 99%

“…There are a number of possible pharmacological approaches which may be effective in reducing postprandial hyperlipidemia in obese and diabetic patients, including statins, fibric acid derivatives, nicotinic acid, and oral omega-3 fatty acid supplements [81,101]. However, the changes in diet indicated above, coupled with weight loss and increased exercise, can be remarkably effective in producing immediate improvements [73] and pharmacological intervention is warranted only in the event that the desired reduction is not achieved after 3 to 6 months of the lifestyle changes [81,101].…”

Section: Translation To Preventionmentioning

confidence: 99%

“…However, the changes in diet indicated above, coupled with weight loss and increased exercise, can be remarkably effective in producing immediate improvements [73] and pharmacological intervention is warranted only in the event that the desired reduction is not achieved after 3 to 6 months of the lifestyle changes [81,101].…”

Section: Translation To Preventionmentioning

confidence: 99%

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Postprandial Lipid Metabolism: The Missing Link Between Life-Style Habits and the Increasing Incidence of Metabolic Diseases in Western Countries?~!2009-09-30~!2010-01-26~!2010-03-30~!

Bravo¹,

Napolitano²,

Botham³

2010

TOTRANSMJ

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Postprandial lipemia is the transient increase in blood lipids which occurs after a meal containing fat and is caused by raised levels of triglyceride-rich lipoproteins (TRLs) in the blood. Delayed clearance of TRLs leads to postprandial hyperlipidemia, and there is now a great deal of evidence to support the idea that this condition is an important risk factor for cardiovascular disease (CVD). Western lifestyle habits including: diets low in fresh fruit and vegetables and high in fat and processed food, alcohol consumption, smoking, and lack of exercise tend to promote postprandial hyperlipidemia, and it is a characteristic feature of increasingly common metabolic diseases such as obesity, insulin resistance and type 2 diabetes which are also linked to modern lifestyle behaviour and which carry an increased risk of CVD development. Modification of lifestyle factors such as changing to a healthier diet, weight loss, reducing alcohol consumption and increasing exercise can cause significant reductions in postprandial hyperlipidemia and thus help to reduce this risk. Despite the growing recognition that the extent of postprandial lipemia is a good predictor of CVD, no standardized methodology for its measurement is currently available. Determination of blood TG levels after consumption of a standard test meal is likely to be the most convenient approach for a routine clinical test, and we propose a standard test meal which is easily adaptable for the variations in dietary habits in different countries. Greater use of postprandial lipid determination will aid in the translation of our extensive knowledge on the role of nutrition in health into national and international policy.

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Section: Postprandial Lipemia and Metabolic Dis-easesmentioning

confidence: 99%

Section: Postprandial Lipemia and Metabolic Dis-easesmentioning

confidence: 99%

Section: Postprandial Lipemia and Metabolic Dis-easesmentioning

confidence: 99%

Section: Translation To Preventionmentioning

confidence: 99%

Section: Translation To Preventionmentioning

confidence: 99%

See 3 more Smart Citations

Postprandial Lipid Metabolism: The Missing Link Between Life-Style Habits and the Increasing Incidence of Metabolic Diseases in Western Countries?~!2009-09-30~!2010-01-26~!2010-03-30~!

Bravo¹,

Napolitano²,

Botham³

2010

TOTRANSMJ

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Role of free radical in atherosclerosis, diabetes and dyslipidaemia: larger‐than‐life

Singh

Devi

Gollen

2015

Diabetes Metabolism Res

142

107

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During the past few decades, there have been numerous studies related to free radical chemistry. Free radicals including reactive oxygen species (ROS) and reactive nitrogen species are generated by the human body by various endogenous systems, exposure to different physiochemical conditions, or pathological states, and have been implicated in the pathogenesis of many diseases. These free radicals are also the common by-products of many oxidative biochemical reactions in cells. When free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues. They adversely alter lipids, proteins, and DNA, which trigger a number of human diseases. In a number of pathophysiological conditions, the delicate equilibrium between free radical production and antioxidant capability is distorted, leading to oxidative stress and increased tissue injury. ROS which are mainly produced by vascular cells are implicated as possible underlying pathogenic mechanisms in a progression of cardiovascular diseases including ischemic heart disease, atherosclerosis, cardiac arrhythmia, hypertension, and diabetes. This review summarizes the key roles played by free radicals in the pathogenesis of atherosclerosis, diabetes, and dyslipidaemia. Although not comprehensive, this review also provides a brief perspective on some of the current research being conducted in this area for a better understanding of the role free radicals play in the pathogenesis of atherosclerosis, diabetes, and dyslipidaemia.

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Postprandial Dysmetabolism and Oxidative Stress in Type 2 Diabetes: Pathogenetic Mechanisms and Therapeutic Strategies

Sottero

Gargiulo

Russo

et al. 2015

Medicinal Research Reviews

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Postprandial dysmetabolism in type 2 diabetes (T2D) is known to impact the progression and evolution of this complex disease process. However, the underlying pathogenetic mechanisms still require full elucidation to provide guidance for disease prevention and treatment. This review focuses on the marked redox changes and inflammatory stimuli provoked by the spike in blood glucose and lipids in T2D individuals after meals. All the causes of exacerbated postprandial oxidative stress in T2D were analyzed, also considering the consequence of enhanced inflammation on vascular damage. Based on this in-depth analysis, current strategies of prevention and pharmacologic management of T2D were critically reexamined with particular emphasis on their potential redox-related rationale.

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Postprandial lipemia: An under-recognized atherogenic factor in patients with diabetes mellitus

Cited by 60 publications

References 97 publications

Postprandial Lipid Metabolism: The Missing Link Between Life-Style Habits and the Increasing Incidence of Metabolic Diseases in Western Countries?~!2009-09-30~!2010-01-26~!2010-03-30~!

Postprandial Lipid Metabolism: The Missing Link Between Life-Style Habits and the Increasing Incidence of Metabolic Diseases in Western Countries?~!2009-09-30~!2010-01-26~!2010-03-30~!

Role of free radical in atherosclerosis, diabetes and dyslipidaemia: larger‐than‐life

Postprandial Dysmetabolism and Oxidative Stress in Type 2 Diabetes: Pathogenetic Mechanisms and Therapeutic Strategies

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