Postprandial insulin and glucose levels are reduced in healthy subjects when a standardised breakfast meal is supplemented with a filtered sugarcane molasses concentrate

Ellis, Timothy P.; Wright, Alison G.; Clifton, Peter; Ilag, Leodevico L.

doi:10.1007/s00394-015-1043-6

Cited by 17 publications

(10 citation statements)

References 47 publications

(50 reference statements)

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“…Randomised double-blind, placebo-controlled clinical trials involving cancer patients with suboptimal omega-3 indices and AA/EPA ratios with corresponding microbiome profiles, need to be conducted. Although n-3 PUFA treatment of healthy individuals did not lead to major shift in microbial diversity [ 25 ], this is consistent with response of healthy subjects with optimal metabolic parameters to treatment with resveratrol [ 46 ], while subjects with suboptimal metabolic parameters are more responsive to treatment with a polyphenol rich fraction from filtered molasses concentrate [ 47 ]. It is postulated that subjects with dysbiosis will have a stronger response to n-3 PUFA treatment leading to major shifts in microbial diversity.…”

Section: Hypothesis: N-3 and N-6 Pufas Modulate The Microbiome Andmentioning

confidence: 59%

Are Long-Chain Polyunsaturated Fatty Acids the Link between the Immune System and the Microbiome towards Modulating Cancer?

Ilag¹

2018

Medicines

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Three recent studies revealed synergy between immune-checkpoint inhibitors and the microbiome as a new approach in the treatment of cancer. Incidentally, there has been significant progress in understanding the role of polyunsaturated fatty acids (PUFAs) in modulating cancer and the immune system, as well as in regulating the microbiome. Inflammation seems to be the common denominator among these seemingly unrelated biological entities—immune system, the microbiome, and long-chain polyunsaturated fatty acids (LC-PUFAs). This commentary presents a hypothesis proposing the existence of an optimal level of LC-PUFAs that nurtures the suitable gut microbiota preventing dysbiosis. This synergy between optimal LC-PUFAs and gut microbiota helps the immune system overcome the immunosuppressive tumour microenvironment including enhancing the efficacy of immune checkpoint inhibitors. A model on how LC-PUFAs (such as omega(n)-3 and n-6 fatty acids) forms a synergistic triad with the immune system and the microbiome in regulating inflammation to maintain homeostasis is presented. The principles underlying the hypothesis provide a basis in managing and even preventing cancer and other chronic diseases associated with inflammation.

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Section: Hypothesis: N-3 and N-6 Pufas Modulate The Microbiome Andmentioning

confidence: 59%

Are Long-Chain Polyunsaturated Fatty Acids the Link between the Immune System and the Microbiome towards Modulating Cancer?

Ilag¹

2018

Medicines

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“…Yoshino et al reported that after 12 weeks of supplementation with resveratrol (75 mg/day), there was no decrease in body weight for non-obese women with normal glucose tolerance [35]. A phytochemical and mineral-rich filtered sugarcane molasses concentrate (FMC) as an agent that can reduce insulin responses and lessen the load on the pancreatic beta cells [36]. However, all phenolic compounds responsible for the differences in the results differences warrant additional studies involving urinalysis.…”

Section: Discussionmentioning

confidence: 99%

White Sweet Potato as Meal Replacement for Overweight White-Collar Workers: A Randomized Controlled Trial

Shih

Chen

Hsiao³

et al. 2019

Nutrients

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Overweight and obesity are a global concern. Meal replacements (MRs) are portion- and calorie-controlled meals, which make the food environment part of an individual’s weight loss regimen. White sweet potato (WSP; Ipomoea batatas L.), used in traditional medicine in Brazil, Japan, and Taiwan, is a healthy carbohydrate source. In this randomized controlled trial, we assessed the effects of a WSP formula on body weight management in 58 white-collar workers through MR to elucidate the effects of this WSP-MR on factors leading to overweight. The participants consumed either two packs a day for a total of 132 g of WSP (WSP-MR group) or a normal diet daily (non-WSP group) for eight weeks. After eight weeks, body weight, body fat, body mass index, wrist circumference, thigh circumference, calf circumference, mid-arm circumference, and triceps skinfolds decreased significantly in both the groups. Moreover, the WSP-MR group demonstrated a 5% decrease in body weight, body fat, body mass index, and mid-arm circumference and a 3.5% decrease in glycated hemoglobin levels (p < 0.05). The treatment was well tolerated, without side effects or adverse events. Thus, our WSP formula as an MR can facilitate individual weight loss and thus has commercial application in the food industry.

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“…interestingly, molasses treatment resulted in minimization of the increased serum glucose level. The result might be due to the abundance of phytochemicals and minerals in molasses that decreased the load of oxidative stress on pancreatic β cells, lowered the insulin responses and improved insulin sensitivity (Ellis et al, 2016). In addition, the decrease in glucose level might be explained by a delay in the carbohydrates digestion because molasses has a low index of glucose and inhibitory effect on α-amylase, α-glucosidase and glucose transporter activity in the gut (Kong et al, 2016;Zhang et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effect of Sugarcane (Blackstrap) Molasses against Gamma Radiation or Manganese- Induced Testicular Toxicity in Male Albino Rats

et al. 2019

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S UGARCANE molasses is a potent antioxidant. Radiation and excess manganese are toxins causing a wide range of adverse effects that can be severe and induce tissues damage to mammals. In an attempt to minimize these effects, the present study aims to evaluate the mitigating effect of molasses on radiation or manganese toxicity-induced testicular tissue damage. Rats were whole-body gamma-irradiated with a single dose of 6Gy, or administered MnCl 2 4H 2 O in a single intraperitoneal injection (100mg/kg body weight). The results showed that molasses treatment (200mg/ 100g body weight/day) for seven days post-radiation or manganese toxicity induced a marked amelioration in the oxidative stress biomarkers of serum and testicular tissues of rats manifested by decreased levels of total nitrate/nitrite (NOx) and malondialdehyde (MDA) associated with an elevation in the total antioxidant capacity (TAC). Molasses treatment has induced also a significant elevation in the mitochondrial cytochrome c oxidase (COX). Marked improvement in the level of serum testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and glucose was also observed. Moreover, molasses was effective in modulating the concentration levels of copper (Cu), iron (Fe), zinc (Zn), manganese (Mn) and selenium (Se) in testicular tissue and epididymis. Additionally, the epididymal sperm count, as well as motility and viability percentage had markedly increased in rats treated with molasses, whereas there was a significant decrease in the number of sperms with abnormal morphology. In conclusion, sugarcane molasses can be considered as a new natural mitigating agent on the testicular injury induced by radiation or Mn-toxicity.

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Postprandial insulin and glucose levels are reduced in healthy subjects when a standardised breakfast meal is supplemented with a filtered sugarcane molasses concentrate

Abstract: FMC shows promise as an agent that can reduce insulin responses and lessen the load on the pancreatic beta cells.

Cited by 17 publications

References 47 publications

Are Long-Chain Polyunsaturated Fatty Acids the Link between the Immune System and the Microbiome towards Modulating Cancer?

Are Long-Chain Polyunsaturated Fatty Acids the Link between the Immune System and the Microbiome towards Modulating Cancer?

White Sweet Potato as Meal Replacement for Overweight White-Collar Workers: A Randomized Controlled Trial

Ameliorative Effect of Sugarcane (Blackstrap) Molasses against Gamma Radiation or Manganese- Induced Testicular Toxicity in Male Albino Rats

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