Postprandial Hyperlipidemia: Association with Inflammation and Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis

Mena-Vázquez, Natalia; Redondo-Rodríguez, Roció; Villodres, José Rioja; Jiménez-Núñez, F. G.; Manrique-Arija, Sara; Lisbona-Montañez, Jose Manuel; Cano-García, Laura; Rojas-Giménez, M.; Ureña, I.; Valdivielso, Pedro; Nebro, Antonio Fernández

doi:10.3390/biomedicines10010133

Cited by 10 publications

(7 citation statements)

References 46 publications

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“…Uslu Yurteri et al 9 study failed to document such relation. In support of our conclusions, elevated CRP levels were frequently linked to SCA in many clinical conditions including rheumatoid arthritis, 20 newly diagnosed diabetes 21 and psoriasis. 22 In our work, endocan levels were significantly elevated in BD patients as compared to healthy controls.…”

Section: Discussionsupporting

confidence: 89%

Serum Endocan Levels and Subclinical Atherosclerosis in Behçet’s Syndrome

Nassef¹,

Elabd²,

nagger³

et al. 2022

IJGM

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Background and Aim Behçet disease (BD) is a rare chronic relapsing-remitting inflammatory systemic vasculitis. BD patients were reported to have marked acceleration of subclinical atherosclerosis (SCA). Endocan is a soluble proteoglycan mainly secreted by the activated endothelium. The present study aimed to assess the relation between serum endocan levels and SCA in BD patients. Subjects and Methods The study included 40 adult BD patients in addition to twenty age- and sex-matched healthy controls. BD was diagnosed according to International Study Group criteria. Upon recruitment, all participants were subjected to careful history taking and thorough clinical examination. BD activity was assessed using Behçet Syndrome Activity Score. Measurement of serum endocan was performed using quantitative double-antibody sandwich ELISA kit. CIMT measurement was done using B-mode ultrasound. Results Comparison between patients and controls regarding serum endocan levels revealed significantly higher endocan levels in BD patients [median (IQR): 155.0 (69.3–610.0) versus 73.8 (51.9–94.6)]. Using ultrasound assessment, SCA was found in 14 BD patients (35.0%). Comparison between patients with SCA and patients without regarding the clinical and laboratory data revealed that the former group had significantly higher CRP [median (IQR): 36.5 (26.8–43.5) versus 21.0 (11.8–26.8) mg/dL, p < 0.001] and endocan [median (IQR): 622.0 (107.4–974.8) versus 104.5 (64.0–342.0) mg/dL, p = 0.004] levels. Logistic regression analysis recognized endocan [OR (95% CI): 1.0 (1.0–1.012), p0.035] levels as significant predictor of SCA in multivariate analysis. Conclusion The present study identified the clinical value of serum endocan levels as a possible early marker of vascular involvement in BD patients.

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Section: Discussionsupporting

confidence: 89%

Serum Endocan Levels and Subclinical Atherosclerosis in Behçet’s Syndrome

Nassef¹,

Elabd²,

nagger³

et al. 2022

IJGM

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“…Moreover, nearly 8% of all disease burden in developed countries is due to elevated blood cholesterol [ 10 ]. In addition, several studies have shown that hyperlipidemia and inflammation are closely interconnected and have a significant contribution to certain cardiovascular diseases such as atherosclerosis [ 14 , 15 ]. A recent study has shown that blockade of interleukin (IL)-1b reduces the incidence of cardiovascular events in patients diagnosed with myocardial infarction and C-reactive protein levels > 2 mg/L.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory, cytotoxicity and antilipidemic properties: novel bioactivities of true cinnamon (Cinnamomum zeylanicum Blume) leaf

Abeysekera

Premakumara

Ratnasooriya

et al. 2022

BMC Complement Med Ther

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Background The leaf of Ceylon cinnamon (true cinnamon) is traditionally claimed for a variety of health benefits. However, reported scientific information is scanty and needs urgent attention for value addition. Methods Ethanolic (95%) and Dichloromethane:Methanol (DM, 1:1 v/v) leaf extracts of Ceylon cinnamon were evaluated for a range of medically important bioactivities namely anti-inflammatory [nitric oxide scavenging activity (NOSA), superoxide scavenging activity (SCA), COX1 and COX2 inhibition], growth inhibition & cytotoxicity against MCF7, HePG2 and AN3CA carcinoma cell lines, glutathionase-S-transferase (GST) inhibition and antilipidemic (anti-HMG-CoA reductase, anti-lipase, anti-cholesterol esterase, and cholesterol micellization inhibition) properties in vitro (n = 3). Further, a range of bioactive compounds in both leaf extracts was also quantified (n = 3). Results Both leaf extracts had all the investigated bioactive compounds and possessed moderately potent bioactivities compared to the reference drugs used in the study. Ethanolic leaf extract (ELE) exhibited the highest activities (IC50: μg/mL) for NOSA (40.26 ± 0.52), SCA (696.24 ± 40.02), cholesterol esterase inhibition (110.19 ± 1.55), cholesterol micellization inhibition (616.69 ± 7.09), GST inhibition (403.78 ± 2.70) and growth inhibition (GI50: 144.84 ± 1.59-269.00 ± 0.51) & cytotoxicity (LC50: 355.44 ± 9.38-717.71 ± 23.69) against studied cancer cell lines. In contrast, COX1 & COX2 (IC50: 6.62 ± 0.85 and 44.91 ± 3.06 μg/mL) and HMG-CoA reductase & lipase inhibitory activities (36.72 ± 4.74 and 19.71 ± 0.97% inhibition at 200 and 600 μg/mL) were highest in DM extract. ELE also showed the highest quantities (0.81 ± 0.06-104.38 ± 1.79) of tested compounds (mg/g extract) where eugenol was the highest and gallic acid was the lowest among quantified. Conclusion Both leaf extracts of Ceylon cinnamon had all the tested bioactive compounds and possess all the investigated bioactivities. This is the 1st study to report all the investigated bioactivities of the leaf of Ceylon Cinnamon.

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“…131 Mena-Vázquez et al found that PPHL in RA patients was significantly associated with subclinical atherosclerosis, TNF-α, and high-sensitivity C-reactive protein, suggesting that PPHL in RA is associated with inflammation and subclinical atherosclerosis. 95 Other studies have also found that cIMT is associated with postprandial ApoB48 and total ApoB, providing evidence that atherogenic chylomicron remnants contribute to atherosclerosis in RA. 103,132 Biomarkers associated with bone turnover such as osteoprotegerin (OPG) have been associated with CAC, carotid plaque, and IMT.…”

Section: The Role Of Endothelial Dysfunctionmentioning

confidence: 89%

Accelerated atherosclerosis in rheumatoid arthritis: a systematic review

Thomas

Gorantla

2022

F1000Res

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Background: Rheumatoid arthritis (RA) is a highly prevalent, chronic inflammatory condition of the synovial joints that affects approximately 1% of the global population. The pathogenesis of RA is predominantly inflammatory in nature, thereby accelerating the co-occurrence of other immunoinflammatory conditions such as atherosclerosis. Apart from traditional cardiovascular risk factors, RA patients possess a multitude of other factors that predispose them to early atherosclerotic disease. The aim of this systematic review is to assess the prevalence of premature atherosclerosis in RA patients and elucidate the role that proinflammatory cytokines, neutrophil extracellular traps, RA-related autoantibodies, and endothelial dysfunction play in the pathophysiology of RA-mediated atherosclerosis. We also discussed novel biomarkers that can be used to predict early atherosclerosis in RA. Methods: This review followed the PRISMA guidelines to select and analyze relevant articles. A literature search for articles was performed on February 25, 2022, through three research databases including PubMed, ProQuest, and ScienceDirect. The query used to identify relevant publications was “Rheumatoid arthritis and atherosclerosis” and the search duration was set from 2011-2022. Relevant articles were selected based on the inclusion and exclusion criteria. Results: Our initial search generated 21,235 articles. We narrowed our search according to the inclusion and exclusion criteria. After assessing eligibility based on the full content of the articles, 73 articles were ultimately chosen for this review. Conclusion: There is a high prevalence of accelerated atherosclerosis among RA patients. We found evidence to explain the role of proinflammatory cytokines, neutrophil extracellular traps, RA-related autoantibodies, and endothelial dysfunction in the pathophysiology RA-mediated atherosclerosis. Therapies targeting either the inflammatory load or traditional CV risk-factors seem to improve vascular outcomes in RA patients. Novel markers of atherosclerosis in RA may be useful in predicting premature atherosclerosis and serve as new targets for therapeutic intervention.

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Postprandial Hyperlipidemia: Association with Inflammation and Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis

Cited by 10 publications

References 46 publications

Serum Endocan Levels and Subclinical Atherosclerosis in Behçet’s Syndrome

Serum Endocan Levels and Subclinical Atherosclerosis in Behçet’s Syndrome

Anti-inflammatory, cytotoxicity and antilipidemic properties: novel bioactivities of true cinnamon (Cinnamomum zeylanicum Blume) leaf

Accelerated atherosclerosis in rheumatoid arthritis: a systematic review

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