Postprandial Electrogastrographic Changes with or without Parasympathetic Nerve Blockade.

Kobayashi, Yuka; Kamiya, Tetsuro

doi:10.1540/jsmr.33.203

Cited by 3 publications

(3 citation statements)

References 16 publications

(13 reference statements)

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“…A slight but significant increase in the EGG dominant frequency was observed following glucose intake, whereas this was not seen after oral water intake. In some studies Koch et al, 1987;Geldof et al, 1989;Chen et al, 1991;Kobayashi et al, 1997), a slight but significant increase in EGG dominant frequency was observed after food intake in healthy subjects. The changes in EGG dominant frequency after glucose intake are similar to the responses to food intake.…”

Section: Discussionmentioning

confidence: 98%

Effects of oral glucose intake on gastric myoelectrical activity and gastric emptying

Misu

Kamiya

Kobayashi

et al. 2004

J. Smooth Muscle Res.

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AbstractsTo investigate the effect of oral glucose intake on gastric motility, we measured gastric myoelectrical activity and gastric emptying on two test conditions: 1) glucose intake and 2) water intake in the same 10 healthy male volunteers (20 to 29 years old). Gastric motility was evaluated with cutaneous-recorded electrogastrography (EGG) for 30 min both on fasting and after glucose or water intake, while gastric emptying was measured using acetaminophen-absorption method. There were no significant changes in EGG dominant frequency after water intake, but the frequency increased significantly after glucose intake. A postprandial dip (i.e., a transient decrease in frequency immediately after the food intake) was observed in 3 subjects after water intake and in 8 subjects following glucose intake. The EGG power ratio was significantly larger after glucose than water intake, with delayed gastric emptying in the former case. These results suggest that glucose is one of the components responsible for postprandial gastric motility.

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Section: Discussionmentioning

confidence: 98%

Effects of oral glucose intake on gastric myoelectrical activity and gastric emptying

Misu

Kamiya

Kobayashi

et al. 2004

J. Smooth Muscle Res.

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“…The marked post-meal drop in systolic and diastolic BP would be the result of reduced RA levels combined with the secretion of vasodilatory gut peptides, such as neurotensin and insulin (Shibao et al 2007). Note that the decrease in RA and BP could also reflect the predominance of parasympathetic activity during the postprandial state, as described by Kobayashi and Kamiya (1997). Finally, although BP does not drop at night in healthy dogs fed a normal-sodium diet at 07:00 h (Mochel et al 2013a), it certainly does in dogs fed at 19:00 h (Mochel et al 2014a), indicating that similar to humans, lower BP levels are to be expected at nights when dogs are given an evening meal.…”

Section: Components Of the Renin Cascade Blood Pressure And Urinarymentioning

confidence: 95%

Chronobiology and Pharmacologic Modulation of the Renin–Angiotensin–Aldosterone System in Dogs: What Have We Learned?

Mochel

Danhof

2015

Reviews of Physiology, Biochemistry and Pharmacology Vol. 169

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Congestive heart failure (CHF) is a primary cause of morbidity and mortality with an increasing prevalence in human and canine populations. Recognition of the role of renin-angiotensin-aldosterone system (RAAS) overactivation in the pathophysiology of CHF has led to significant medical advances. By decreasing systemic vascular resistance and angiotensin II (AII) production, angiotensin-converting enzyme (ACE) inhibitors such as benazepril improve cardiac hemodynamics and reduce mortality in human and dog CHF patients. Although several experiments have pointed out that efficacy of ACE inhibitors depends on the time of administration, little attention is paid to the optimum time of dosing of these medications. A thorough characterization of the chronobiology of the renin cascade has the potential to streamline the therapeutic management of RAAS-related diseases and to help determining the optimal time of drug administration that maximizes efficacy of ACE inhibitors, while minimizing the occurrence of adverse effects. We have developed an integrated pharmacokinetic-pharmacodynamic model that adequately captures the disposition kinetics of the paradigm drug benazeprilat, as well as the time-varying changes of systemic renin-angiotensin-aldosterone biomarkers, without and with ACE inhibition therapy. Based on these chronobiological investigations, the optimal efficacy of ACE inhibitors is expected with bedtime dosing. The data further show that benazepril influences the dynamics of the renin-angiotensin-aldosterone cascade, resulting in a profound decrease in AII and aldosterone (ALD), while increasing renin activity for about 24 h. From the results of recent investigations in human, it is hypothesized that reduction of AII and ALD is one of the drivers of increased survival and improved quality of life in dogs receiving ACE inhibitors. To support and consolidate this hypothesis, additional efforts should be directed toward the collection of circulating RAAS peptides in spontaneous cases of canine CHF. If such a link could be established, profiling of these biomarkers could support determination of the severity of heart failure, complement clinical and echocardiographic findings, and be used for therapeutic drug monitoring purposes.

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“…continuous non-invasive data recording. Among them, the electrogastrogram (EGG) [17] provides a tool that allows the influence of sympathetic and parasympathetic activity on gastric activity to be observed [18,19]. To date, a few studies have examined the effects of imagining - favorable or unfavorable - food on the EGG [20-22].…”

Section: Introductionmentioning

confidence: 99%

Sensitivity and Specificity of Hypnosis Effects on Gastric Myoelectrical Activity

et al. 2013

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ObjectivesThe effects of hypnosis on physiological (gastrointestinal) functions are incompletely understood, and it is unknown whether they are hypnosis-specific and gut-specific, or simply unspecific effects of relaxation.DesignSixty-two healthy female volunteers were randomly assigned to either a single session of hypnotic suggestion of ingesting an appetizing meal and an unappetizing meal, or to relax and concentrate on having an appetizing or unappetizing meal, while the electrogastrogram (EGG) was recorded. At the end of the session, participants drank water until they felt full, in order to detect EGG-signal changes after ingestion of a true gastric load. During both conditions participants reported their subjective well-being, hunger and disgust at several time points. ResultsImagining eating food induced subjective feelings of hunger and disgust as well as changes in the EGG similar to, but more pronounced than those seen with a real gastric water load during both hypnosis and relaxation conditions. These effects were more pronounced when imagining an appetizing meal than with an unappetizing meal. There was no significant difference between the hypnosis and relaxation conditions. ConclusionImagination with and without hypnosis exhibits similar changes in subjective and objective measures in response to imagining an appetizing and an unappetizing food, indicating high sensitivity but low specificity.

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Postprandial Electrogastrographic Changes with or without Parasympathetic Nerve Blockade.

Cited by 3 publications

References 16 publications

Effects of oral glucose intake on gastric myoelectrical activity and gastric emptying

Effects of oral glucose intake on gastric myoelectrical activity and gastric emptying

Chronobiology and Pharmacologic Modulation of the Renin–Angiotensin–Aldosterone System in Dogs: What Have We Learned?

Sensitivity and Specificity of Hypnosis Effects on Gastric Myoelectrical Activity

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