Postpartum placental CT angiography in normal pregnancies and in those complicated by diabetes mellitus

Thunbo, Mette Østergaard; Sinding, Marianne; Bogaard, Pauline; Korsager, Anne Sofie; Frøkjær, Jens Brøndum; Østergaard, Lasse Riis; Petersen, Astrid; Sørensen, Anne

doi:10.1016/j.placenta.2018.06.309

Cited by 11 publications

(5 citation statements)

References 43 publications

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“…The clinical value of placental T2* needs to be explored in other clinical cohorts such as pregnancies complicated by diabetes [33][34][35] and late-onset placental dysfunction 36,37 . In these pregnancies, the predictive performance of fetal Doppler flow is particularly limited, and additional methods focusing directly on placental function are highly needed to improve the antenatal identification of placental dysfunction.…”

Section: Research Implicationsmentioning

confidence: 99%

T2*-weighted placental magnetic resonance imaging: a biomarker of placental dysfunction in small-for-gestational-age pregnancies

Hansen

Sinding

Petersen

et al. 2022

American Journal of Obstetrics & Gynecology MFM

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Section: Research Implicationsmentioning

confidence: 99%

T2*-weighted placental magnetic resonance imaging: a biomarker of placental dysfunction in small-for-gestational-age pregnancies

Hansen

Sinding

Petersen

et al. 2022

American Journal of Obstetrics & Gynecology MFM

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“…Особенности сосудистого русла в диабетических и нормальных плацентах были изучены с помощью компьютерной томографии (КТ) в работе Thunbo M. и соавт. [39]. Проанализирован объем фетоплацентарного сосудистого пространства с помощью послеродовой КТ-ангиографии плацент с контрастом при нормальной беременности (27 беременностей) и при осложнениях у пациенток с СД1 (25 беременностей), с ГСД на диете (8 беременностей) и ГСД на инсулинотерапии (9 беременностей), а также проведено гистологическое исследование плацент.…”

Section: влияние сахарного диабета на формирование фетоплацентарного комплексаunclassified

“…Эти данные могут объяснить, почему у плодов от беременности при СД на инсулинотерапии наблюдается повышенная уязвимость к внутриутробной и интранатальной асфиксии. Гистологическое исследование подтвердило, что патология плаценты преимущественно наблюдается при беременностях, осложненных инсулинозависимым диабетом [39].…”

Section: влияние сахарного диабета на формирование фетоплацентарного комплексаunclassified

Comparative morphofunctional analysis of the state of fetoplacental complex in diabetes mellitus (literature review)

Grigoryan

Absatarova

Михеев

et al. 2020

Probl Endokrinol (Mosk)

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This article reviews the literature on placental morphofunctional changes in placenta of patients with type 1 and type 2 diabetes mellitus and gestational diabetes mellitus. The detailed analysis of features of pathogenesis of various abnormalities of the fetoplacental complex depending on the type of diabetes, its influence on the formation of the placental vascular bed. The analysis of mechanisms of development of placenta formation disorders, pathologies of placental vascular bed, the role of hyperglycemia and hyperinsulinemia in villous maturation, placental weight gain, perinatal outcomes. The discussed anomalies have a significant impact on the fetoplacental complex, acting as epigenetic factors, forming the environment for the fetus, which may later affect the health of the unborn child. They lead to adverse perinatal outcomes, including high infant morbidity and mortality. Literature search was performed in Russian (eLibrary, CyberLeninka.ru) and international (PubMed, Cochrane Library) databases in Russian and English languages. The free access to the full text of the articles was in priority. The selection of sources was prioritized for the period from 2016 to 2020. However, due to the lack of knowledge of the chosen topic, the selection of sources was dated from 2001.

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“…Imaging of the whole human placenta, using a corrosion technique, has also been investigated [13], finding a significantly smaller number of chorionic artery branches [13] and longer venous and shorted arterial vasculature in fetal growth restriction compared to normal placentas [14]. Standard Computed Tomography angiography has been used to investigate the microvasculature of the placenta, finding no difference in macrovascular volume between normal and FGR placenta, despite a reduction in placental size [15].…”

Section: Introductionmentioning

confidence: 99%

Micro-CT and histological investigation of the spatial pattern of feto-placental vascular density

et al. 2019

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IntroductionThere are considerable variations in villous morphology within a normal placenta. However, whether there is a reproducible spatial pattern of variation in villous vascular density is not known. Micro-CT provides three-dimensional volume imaging with spatial resolution down to the micrometre scale. In this study, we applied Micro-CT and histological analysis to investigate the degree of heterogeneity of vascularisation within the placenta.MethodTen term placentas were collected at elective caesarean section, perfused with contrast agent and imaged whole with Micro-CT. Eight full depth tissue blocks were then taken from each placenta and imaged. Sections were taken for histological analysis. Data was analysed to investigate vascular fill, and vascular density in relation to location from cord insertion to placental edge at each scale.ResultsWhole placental imaging revealed no spatially consistent difference in villous vessel density within the main placental tissue, although there was a great degree of heterogeneity. Both block imaging and histological analysis found a large degree of heterogeneity of vascular density within placentas, but no strong correlation between villous vascular density and block location (rs = 0.066, p = 0.7 block imaging, rs = 0.06, p = 0.6 histological analysis).DiscussionThis work presents a novel method for imaging the human placenta vascular tree using multiscale Micro-CT imaging. It demonstrates that there is a large degree of variation in vascular density throughout normal term human placentas. The three-dimensional data created by this technique could be used, with more advanced computer analysis, to further investigate the structure of the vascular tree.

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Postpartum placental CT angiography in normal pregnancies and in those complicated by diabetes mellitus

Cited by 11 publications

References 43 publications

T2*-weighted placental magnetic resonance imaging: a biomarker of placental dysfunction in small-for-gestational-age pregnancies

T2*-weighted placental magnetic resonance imaging: a biomarker of placental dysfunction in small-for-gestational-age pregnancies

Comparative morphofunctional analysis of the state of fetoplacental complex in diabetes mellitus (literature review)

Micro-CT and histological investigation of the spatial pattern of feto-placental vascular density

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