Postpartum nitric oxide, oxidants and antioxidants levels in ewes and their lambs

Soriano, Vanessa Souza; Sá, Jonathan; Rampazzo, Honorino Pedro; Torbitz, Vanessa Dorneles; Moresco, Rafael Noal; Stefani, Lenita M.; Silva, Aleksandro Schafer Da

doi:10.1016/j.smallrumres.2014.09.010

Cited by 15 publications

(9 citation statements)

References 27 publications

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“…The growing interest in the effect of OS and antioxidantenriched diets on livestock welfare and the quality of derived products has prompted the use of analytical methods, already in use in human medicine for many years, also for the evaluation of the redox potential in animal biological samples (Cecchini et al, 2019;Celi, 2011a;Chávez-Servín et al, 2018;Di Trana et al, 2015;Giorgio et al, 2019;Todaro et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Assessment of total (anti)oxidant status in goat kids

Gualandi

Fazio

2021

Arch. Anim. Breed.

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Abstract. The redox potential of goat serum was assessed by different spectrophotometric assays. Among them, three methods are commonly applied for the evaluation of the oxidative (reactive oxygen metabolites, ROMs, and total oxidant status, TOS) and nitrosative (NO⚫ metabolites, NOx) stress, and four methods for the evaluation of the antioxidant status: the total antioxidant capacity (TAC) based on the ferric reducing ability of plasma (FRAP), the total antioxidant activity (TAA) based on the reduction of the coloured ABTS⚫+ radical cation, the free radical scavenging activity (FRSA) based on the reduction of the purple DPPH⚫, and the total thiol levels (TTLs) based on their interaction with DTNB to form a highly coloured anion. Besides, myeloperoxidase (MPO) and ceruloplasmin oxidase (CP) activities were also assessed. Except for TAA, analytical data showed a great inter-individual variation for both oxidant and antioxidant assays. ROMs were strongly correlated with CP, while TOS with MPO and TAC. Furthermore, a tendency between TOS and FRSA was shown. NOx was correlated with TAC and TAA, and a tendency with TOS was shown. No correlations appeared among the antioxidant assays, even if a tendency between TAC and TAA was evidenced, but TAC was correlated with MPO activity. The observed correlation between ROMs and CP is discussed as a possible analytical interference. The absence of correlation among the antioxidant biomarkers suggests the simultaneous use of a panel of tests to verify any changes in the redox balance, mainly in livestock in which reference values for each biomarker are lacking.

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Section: Introductionmentioning

confidence: 99%

Assessment of total (anti)oxidant status in goat kids

Gualandi

Fazio

2021

Arch. Anim. Breed.

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“…The activity of oxidative stress biomarkers can be influenced by nutrition. The relationship between diet and oxidative stress has received little research interest during pregnancy in goats [ 5 ] and sheep [ 9 ]. The oxidative status may be impaired during the pregnancy period.…”

Section: Introductionmentioning

confidence: 99%

Impact of pregnancy and nutrition on oxidant⁄antioxidant balance in sheep and goats reared in South Sinai, Egypt

Nawito¹,

Hameed²,

Sosa³

et al. 2016

Vet World

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Aim:To monitor the effect of nutrition and pregnancy on oxidative status of animals under the arid condition of South Sinai.Materials and Methods:Blood samples were taken from two groups of animals: The first group retained in farm and fed on concentrate (high diet) and another group grazing natural forage (low diet). Each group was subdivided into pregnant and non-pregnant animals. Blood samples were assayed for their content of malondialdehyde (MDA), total antioxidant capacity (TAC), catalase (CAT), and superoxide dismutase (SOD) enzymes.Results:MDA level significantly increased in pregnant animals fed either concentrate or grazing low-quality forage and accompanied by a low level of TAC in pregnant grazing animals fed low-quality forage. The activity of CAT decreased in pregnant fed either concentrate or grazing and SOD significant decrease in the pregnant grazing group. These data suggested that the animals might have experienced some degree of oxidative stress and lipid peroxidation and indicating that redox homeostasis was impaired in those pregnant and specially fed on forage rations.Conclusion:Pregnancy constituted the most oxidative stress facing the grazing and concentrated diet feed sheep and goats under arid and saline conditions of Southern Sinai, Egypt.

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“…At the same time, the oxidative stress index (OSI = oxidation level/antioxidant level) is unchanged despite the increases in TOS and TAC. The OSI decreases and NOx levels increase significantly 1 week postpartum ( 17 , 94 ), indicating that redox status and oxidative stress during late pregnancy and the postpartum period are different.…”

Section: Redox Statusmentioning

confidence: 99%

Precision Redox: The Key for Antioxidant Pharmacology

Meng

Zhang

et al. 2021

Antioxidants & Redox Signaling

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Significance: The redox balance of cells provides a stable microenvironment for biological macromolecules to perform their physiological functions. As redox imbalance is closely related to the occurrence and development of a variety of diseases, antioxidant therapies are an attractive option. However, redox-based therapeutic strategies have not yet shown satisfactory results. To find the key reason is of great significance. Recent Advances: We emphasize the precise nature of redox regulation and elucidate the importance and necessity of precision redox strategies from three aspects: differences in redox status, differences in redox function, and differences in the effects of redox therapy. We then propose the “5R” principle of precision redox in antioxidant pharmacology: “Right species, Right place, Right time, Right level, and Right target.” Critical Issues: Redox status must be considered in the context of species, time, place, level, and target. The function of a biomacromolecule and its cellular signaling role are closely dependent on redox status. Accurate evaluation of redox status and specific interventions are critical for the success of redox treatments. Precision redox is the key for antioxidant pharmacology. The precise application of antioxidants as nutritional supplements is also key to the general health of the population. Future Directions: Future studies to develop more accurate methods for detecting redox status and accurately evaluating the redox state of different physiological and pathological processes are needed. Antioxidant pharmacology should consider the “5R” principle rather than continuing to apply global nonspecific antioxidant treatments. Antioxid. Redox Signal . 34, 1069–1082.

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Postpartum nitric oxide, oxidants and antioxidants levels in ewes and their lambs

Cited by 15 publications

References 27 publications

Assessment of total (anti)oxidant status in goat kids

Assessment of total (anti)oxidant status in goat kids

Impact of pregnancy and nutrition on oxidant⁄antioxidant balance in sheep and goats reared in South Sinai, Egypt

Precision Redox: The Key for Antioxidant Pharmacology

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