Postpartum depression: Etiology, treatment and consequences for maternal care

Brummelte, Susanne; Galea, Liisa A.M.

doi:10.1016/j.yhbeh.2015.08.008

Cited by 397 publications

(355 citation statements)

References 256 publications

Supporting

Mentioning

306

Contrasting

Unclassified

Order By: Relevance

“…Dysregulated activity of the HPA axis is the most robust neuroendocrine finding in MDD (Heim et al, 2008), and may also be etiologically relevant to PPD (Brummelte and Galea, 2015; Glynn et al, 2013; Jolley et al, 2007). Given the expression of OTRs within key stress-regulatory regions (e.g., amygdala, PVN), stress-buffering effects of OT (Cardoso et al, 2014; Heinrichs et al, 2003), and OT-induced downregulation of amygdala reactivity (Kirsch et al, 2005), OT might serve a protective role against the development of stress-related disorders such as MDD or PPD.…”

Section: Ot and Early-life Stress (Els) – Role In Shaping Neural Cmentioning

confidence: 99%

Oxytocin pathways in the intergenerational transmission of maternal early life stress

Toepfer

Heim

Entringer

et al. 2017

Neuroscience & Biobehavioral Reviews

View full text Add to dashboard Cite

Severe stress in early life, such as childhood abuse and neglect, constitutes a major risk factor in the etiology of psychiatric disorders and somatic diseases. Importantly, these long-term effects may impact the next generation. The intergenerational transmission of maternal early life stress (ELS) may occur via pre-and postnatal pathways, such as alterations in maternal-fetal-placental stress physiology, maternal depression during pregnancy and postpartum, as well as impaired mother-offspring interactions. The neuropeptide oxytocin (OT) has gained considerable attention for its role in modulating all of these assumed transmission pathways. Moreover, central and peripheral OT signaling pathways are highly sensitive to environmental exposures and may be compromised by ELS with implications for these putative transmission mechanisms. Together, these data suggest that OT pathways play an important role in the intergenerational transmission of maternal ELS in humans. By integrating recent studies on gene-environment interactions and epigenetic modifications in OT pathway genes, the present review aims to develop a conceptual framework of intergenerational transmission of maternal ELS that emphasizes the role of OT.

show abstract

Section: Ot and Early-life Stress (Els) – Role In Shaping Neural Cmentioning

confidence: 99%

Oxytocin pathways in the intergenerational transmission of maternal early life stress

Toepfer

Heim

Entringer

et al. 2017

Neuroscience & Biobehavioral Reviews

View full text Add to dashboard Cite

show abstract

“…Psychological and physiological factors are major etiologies for PPD development (5). Psychological factors primarily include anxiety during pregnancy and personality characteristics, while physiological factors include genetic and physical factors, hormone level and the delivery process (6)(7)(8). Currently, drug therapies and psychotherapy are the two most commonly used treatments for PPD, and combined therapy is reported to be more effective than either treatment alone (9,10).…”

Section: Introductionmentioning

confidence: 99%

Timosaponin B-III exhibits antidepressive activity in a mouse model of postpartum depression by the regulation of inflammatory cytokines, BNDF signaling and synaptic plasticity

Zhang

Wang

Xiong

et al. 2017

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. The aim of this study was to investigate the antidepressive effects of timosaponin B-III (TB-III) and the underlying mechanism. A postpartum depression (PPD) mouse model was established by the administration of dexamethasone sodium phosphate during pregnancy. Mice with PPD were assigned to the following groups: Model, fluoxetine and high, medium and low doses of TB-III. Post-parturient mice without PPD served as a normal control group. To examine the effect of TB-III, mice were treated with TB-III, then forced swimming tests (FSTs) and tail suspension tests (TSTs) were performed to evaluate depression. Serum and hippocampal cytokines, namely tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and IL-10, were quantified using ELISAs and protein levels of hippocampal brain-derived neurotrophic factor (BDNF), glucagon synthase kinase (GSK)-3β, glutamate receptor subunit 1 (GluR1), postsynaptic density protein 95 (PSD95) and synapsin I were quantified using western blot analysis. Compared with those in the control group, immobility time in the FST and TST, serum and hippocampal TNF-α, IL-1β and IL-6 levels and hippocampal IL-10 levels were increased significantly in the model group (P<0.01). Serum IL-10 levels and hippocampal levels of BDNF, GSK-3β, GluR1, PSD95 and synapsin I decreased significantly in the model group compared with the control group (P<0.01). Fluoxetine or TB-III (10, 20 or 40 mg/kg) treatment significantly decreased immobility times in the FST and TST (P<0.01) and significantly reversed the aforementioned alterations in cytokine and protein levels (P<0.01). Thus, TB-III exhibited a protective effect against depression in PPD and such effects may have been mediated via the regulation of inflammatory cytokines, the BNDF signaling pathway and synaptic plasticity-related proteins. IntroductionPostpartum depression (PPD) is a common mental disease (1), and an incidence of 10-15% has been indicated in the US, although this can be as high as 30% depending on the diagnostic criteria (2,3). Depression prior to pregnancy is one of the greatest risk factors for PPD (4). Psychological and physiological factors are major etiologies for PPD development (5). Psychological factors primarily include anxiety during pregnancy and personality characteristics, while physiological factors include genetic and physical factors, hormone level and the delivery process (6-8). Currently, drug therapies and psychotherapy are the two most commonly used treatments for PPD, and combined therapy is reported to be more effective than either treatment alone (9,10). However, the success rate of treatment is low and the effects are not satisfactory. Therefore, the exploration of new treatments against PPD is critical.Timosaponin B-III (TB-III) is a saponin isolated from Anemar rhenae rhizome, the dry rhizome of Anemarrhena asphodeloides Bge. (Liliaceae). Although it has been reported to exhibit antidepressive effects on behavior, including immobility time in forced swimming tests (FSTs) and tail suspension tests (TSTs)...

show abstract

“…Su relación con los trastornos del estado de ánimo de la mujer durante el embarazo, muestran resultados muy diversos. Situaciones de estrés crónico durante el embarazo, pueden alterar los mecanismos de adaptación neurobiológica del sistema de regulación de muchas de las hormonas que son necesarias para la consecución de los aspectos más importantes de la maternidad como puede ser la conducta de apego (Brummelte y Galea, 2016).…”

Section: Resultados Adversos a Nivel Obstétrico Y Sobre La Conducta Munclassified

“…Teniendo en cuenta estos hallazgos, autores como Brummelte y Galea (2016) sugieren que tanto la oxitocina como los glucocorticoides pueden interactuar durante el embarazo y el posparto para propiciar un aumento en la vulnerabilidad a los estados de ánimo depresivos.…”

Section: Oxitocinaunclassified

“…Los autores determinaron que estos genes están implicados en la señalización mediada por estradiol (en el caso de HP1NP3) y ligados a la plasticidad del hipocampo (en el caso de TTC9B). El hecho de que estas modificaciones epigenéticas estén asociadas con el estradiol y relacionadas con la plasticidad, da crédito a la teoría de que la retirada de estradiol podría estar vinculada a la DPP en las mujeres vulnerables (Brummelte y Galea, 2016).…”

Section: Hallazgos Genéticos Relacionados Con La Depresión Prenatalunclassified

See 1 more Smart Citation

PROYECTO MAMÁFELIZ: Estudio sobre la Salud Mental prenatal a través de Internet

Andreu‐Pejó¹

View full text Add to dashboard Cite

AGRAÏMENTS També es mereixen el meu agraïment totes aquelles dones que han participat en l'estudi, pel seu interès i el seu temps, és per elles que tot l'esforç val la pena. Tan mateix, vull agrair a totes aquelles amigues i companyes de treball que s'han preocupat per mi durant aquest temps, que m'han escoltat, m'han donat suport i sempre han disculpat les meues absències. De manera molt especial, a Adri, gran amiga, que des del primer minut en què tot va començar ha estat sempre al meu costat, no només ajudant-me i ensenyant-me, si no també recolzant-me i transmetent-me la força i ànim que necessitava des de l'estima d'una bona amiga. De la mateixa manera vull agrair a la meua família, especialment a mon pare, ma mare i la meua germana Elia per tot el recolzament i tota l'estima que m'han oferit sempre en tot i cadascun dels projectes que he emprès al llarg dels anys i en particular, per a l'elaboració de la tesi, per ser pacients i comprensius amb mi. També a Draco que encara que ja no està entre nosaltres, m'ha acompanyat a tot arreu durant onze anys, per totes les hores d'estudi que ha estat al meu costat i tot l'amor MARCO TEÓRICO IntroducciónEl embarazo es un periodo de la vida de la mujer caracterizado por múltiples cambios físicos y emocionales que confluyen para favorecer la adaptación de la mujer a su nuevo rol de madre en un contexto sociocultural único. A medida que acontecen dichos cambios algunas mujeres experimentan ciertas dificultades que, en ocasiones, pueden propiciar la aparición de alteraciones emocionales de diversa importancia. De entre las alteraciones emocionales más prevalentes se encuentra la depresión. Las cifras de prevalencia de la depresión prenatal se sitúan entre el 6-20% (p.ej, Bennet et al., 2004a;Gavin et al., 2005;Shakeel et al., 2015). Estos datos sitúan la depresión prenatal como uno de los problemas de salud mental más importantes a nivel mundial por las importantes consecuencias sobre la salud de la propia mujer y el futuro bebé, tanto a corto como a largo plazo.A pesar de su alta prevalencia y relevancia, las alteraciones emocionales perinatales siguen pasando desapercibidas, infradiagnosticadas y, por tanto, no tratadas. Todavía hoy existen multitud de barreras de diferente índole que impiden que una atención integral óptima llegue a todas las mujeres que se encuentran en la etapa prenatal, y que hace que alrededor del 65% de las mujeres que sufren depresión durante el embarazo no sean diagnosticadas (Ko, Farr, Dietz y Robbins, 2012). 2La realidad sanitaria actual muestra un enfoque fundamentalmente biológico que consolida la concepción del embarazo como un hecho meramente médico, dejando al margen factores importantes de la vida de las mujeres como el trabajo, el nivel de estrés, sus experiencias previas, el estado emocional o el aprendizaje sociocultural, factores que pueden ser determinantes en la evolución del proceso de convertirse en madre.Una perspectiva que incluya la valoración del estado emocional de las mujeres durante su embarazo, así como los aspectos so...

show abstract

Postpartum depression: Etiology, treatment and consequences for maternal care

Cited by 397 publications

References 256 publications

Oxytocin pathways in the intergenerational transmission of maternal early life stress

Oxytocin pathways in the intergenerational transmission of maternal early life stress

Timosaponin B-III exhibits antidepressive activity in a mouse model of postpartum depression by the regulation of inflammatory cytokines, BNDF signaling and synaptic plasticity

PROYECTO MAMÁFELIZ: Estudio sobre la Salud Mental prenatal a través de Internet

Contact Info

Product

Resources

About