Postpartum Cardiovascular Prevention: The Need for a National Health Systems-Based Strategy

Dayan, Natalie; Nerenberg, Kara

doi:10.1016/j.cjca.2019.04.004

Cited by 9 publications

(5 citation statements)

References 20 publications

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“…This new knowledge, together with data from other Canadian postpartum CVD prevention clinics, will generate the evidence base to inform models of care on the delivery and effectiveness of CVD risk factor screening and management to reach thousands of high-risk female patients, after they have HDP, each year in Canada. 11 , 44 …”

Section: Discussionmentioning

confidence: 99%

Understanding patient perspectives of specialized, longitudinal postpartum cardiovascular risk reduction clinics

Nix,

Hawkins,

Vlasschaert

et al. 2023

CJC Open

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Section: Discussionmentioning

confidence: 99%

Understanding patient perspectives of specialized, longitudinal postpartum cardiovascular risk reduction clinics

Nix,

Hawkins,

Vlasschaert

et al. 2023

CJC Open

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“…It is during pregnancy and in the first year postpartum that a woman is highly engaged with the health system [ 17 ]. However, not all women with a history of PE will go on to develop CVD, and clinicians lack simple tools to identify women at greatest risk for whom targeted follow-up may be of greatest benefit [ 18 ]. Biomarkers of inflammation are important independent predictors of cardiovascular events in the general population [ 19 , 20 , 21 ] yet are not validated in the postpartum obstetrical population.…”

Section: Discussionmentioning

confidence: 99%

Maternal Immune Cell and Cytokine Profiles to Predict Cardiovascular Risk Six Months after Preeclampsia

Murphy

Benton

Cox

et al. 2022

JCM

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Women who develop preeclampsia (PE) are at high risk for cardiovascular disease (CVD). Early identification of women with PE who may benefit the most from early cardiovascular risk screening and interventions remains challenging. Our objective was to assess whether cytokine and immune cell profiles after PE are helpful in distinguishing women at low and high CVD risk at 6-months postpartum. Individuals who developed PE were followed for immune cell phenotyping and plasma cytokine quantification at delivery, at 3-months, and at 6-months postpartum. Lifetime CVD risk was assessed at 6-months postpartum, and the immune cell and cytokine profiles were compared between risk groups at each time point. Among 31 participants, 18 (58.1%) exhibited high CVD-risk profiles at 6-months postpartum. The proportion of circulating NK-cells was significantly lower in high-risk participants at delivery (p = 0.04). At 3-months postpartum, high-risk participants exhibited a lower proportion of FoxP3+ regulatory T-cells (p = 0.01), a greater proportion of CD8+ T cells (p = 0.02) and a lower CD4+:CD8+ ratio (p = 0.02). There were no differences in immune cell populations at 6-months postpartum. There were no differences in plasma cytokines levels between risk groups at any time point. Subtle differences in immune cell profiles may help distinguish individuals at low and high CVD risk in the early postpartum period and warrants further investigation.

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“… 82 This approach would also allow for concomitant care of women’s partners and children, who might be at increased risk of developing CV risk factors. 83 Provincial and national systems are needed to streamline access to primary care and preventative care resources.…”

Section: Current Status and Challenges: The Influence Of Sex And Gend...mentioning

confidence: 99%

CWHHA ATLAS: EPIDEMIOLOGY, DIAGNOSIS AND MANAGEMENT OF CARDIOVASCULAR DISEASES IN WOMEN Chapter 9: Summary of Current Status, Challenges, Opportunities, and Recommendations

Mulvagh,

Colella,

Gulati

et al. 2023

CJC Open

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Postpartum Cardiovascular Prevention: The Need for a National Health Systems-Based Strategy

Cited by 9 publications

References 20 publications

Understanding patient perspectives of specialized, longitudinal postpartum cardiovascular risk reduction clinics

Understanding patient perspectives of specialized, longitudinal postpartum cardiovascular risk reduction clinics

Maternal Immune Cell and Cytokine Profiles to Predict Cardiovascular Risk Six Months after Preeclampsia

CWHHA ATLAS: EPIDEMIOLOGY, DIAGNOSIS AND MANAGEMENT OF CARDIOVASCULAR DISEASES IN WOMEN Chapter 9: Summary of Current Status, Challenges, Opportunities, and Recommendations

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