Postpartum acute splenic sequestration in sickle cell disease

Noreldeen, S. A.; Oppenheimer, Christina; Chapman, Chris; Pavord, Sue

doi:10.1080/01443610802164003

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…By adulthood, most individuals with HbSS have already undergone splenic infarction, fibrosis, and autosplenectomy, making splenic sequestration in adults an exceedingly rare phenomenon [5,21,22]. However, a small number of cases of splenic sequestration have been reported in adults with heterozygous sickle cell disease, including HbS/β + -thalassemia and sickle cell-hemoglobin C (HbSC), diseases in which splenomegaly often persists into adulthood [5,[7][8][9][10][11][12][13][14][15][16][17][18]22,23].…”

Section: Discussionmentioning

confidence: 99%

“…In the current report, we detail a case of a young adult male with HbS/β + -thalassemia who presented to the hospital and was discovered to be undergoing an acute splenic sequestration crisis. To our knowledge, this is only the nineteenth case of acute splenic sequestration to be reported in an adult with sickle cell beta(+)-thalassemia disease (HbS/ β + -thalassemia) (Table 1) [5,[7][8][9][10][11][12][13][14][15][16][17][18]. Furthermore, this is only the second case in which ultrasound findings are reported [7].…”

Section: Introductionmentioning

confidence: 99%

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Splenic sequestration in the adult: cross sectional imaging appearance of an uncommon diagnosis

2021

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Splenic sequestration in the adult: cross sectional imaging appearance of an uncommon diagnosis

2021

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Adverse outcome of acute splenic sequestration crisis in pregnancy

et al. 2020

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Background Acute splenic sequestration crisis, characterized by abrupt fall in hemoglobin, splenomegaly, hypovolemia, and often thrombocytopenia, occurs infrequently in adults with sickle cell disease and extremely rarely during pregnancy. Case A 25-year-old woman with HbSC presented at 33 weeks’ gestation with vaso-occlusive pain. Sudden worsening of abdominal pain and non-reassuring fetal surveillance on day 3 of admission led to emergent delivery. Acute splenic sequestration crisis was the diagnosis of exclusion based on clinical presentation and intra-operative hemoglobin of 37 g/L. Five- and 10-minute Apgar scores were 4. Neonatal brain magnetic resonance imaging revealed significant diffuse white matter abnormalities. Conclusion Acute splenic sequestration crisis in pregnancy must be considered in the differential diagnosis for this patient population as it can evolve rapidly and lead to maternal and fetal compromise.

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Acute splenic sequestration in a pregnant woman with homozygous sickle-cell anemia

et al. 2013

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CONTEXT: Homozygous (SS) sickle-cell anemia complicated by acute splenic sequestration in adults is a rare event, and it has never been reported during pregnancy. CASE REPORT: A 25-year-old woman with homozygous (SS) sickle-cell disease was hospitalized at 32 weeks' of gestation presenting weakness, abdominal pain, fever and hemoglobin of 2.4 g/dl. Abnormal fetal heart rate was detected by means of cardiotocography, and 5 units of packed red cells were transfused. Cesarean was performed at 37 weeks. Both mother and baby were discharged in a good general condition.CONCLUSION: This case report demonstrates the importance of immediate blood transfusion for treatment of fetal distress in cases of splenic sequestration during pregnancy. This treatment is essential for avoiding maternal and fetal complications.RESUMO CONTEXTO: Anemia falciforme homozigótica (SS) complicada por sequestro esplênico agudo em adultos é evento raro, e nunca foi relatado durante a gravidez. RELATO DO CASO: Uma mulher de 25 anos, portadora de doença falciforme homozigótica (SS), com 32 semanas de gestação, foi internada apresentando fraqueza, dor abdominal, febre e hemoglobina de 2,4 g/ dl. Frequência cardíaca fetal anormal foi detectada pela cardiotocografia e a paciente recebeu 5 unidades de concentrado de hemácias. Cesariana foi realizada com 37 semanas. Mãe e filho receberam alta em bom estado geral. CONCLUSÃO: Este relato de caso demonstra a importância da transfusão imediata para o tratamento de sofrimento fetal nos casos de sequestro esplênico durante a gestação. Este tratamento é imprescindível para se evitarem complicações maternas e fetais.

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Postpartum acute splenic sequestration in sickle cell disease

Cited by 3 publications

References 5 publications

Splenic sequestration in the adult: cross sectional imaging appearance of an uncommon diagnosis

Splenic sequestration in the adult: cross sectional imaging appearance of an uncommon diagnosis

Adverse outcome of acute splenic sequestration crisis in pregnancy

Acute splenic sequestration in a pregnant woman with homozygous sickle-cell anemia

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