Postovulatory treatment with GnRH on day 5 reduces pregnancy loss in recipients receiving an in vitro produced expanded blastocyst

García-Guerra, A.; Sala, R. V.; Carrenho-Sala, L. C.; Baez, Giovanni M.; Motta, J. C. Lemos; Fosado, M.; Moreno, J. F.; Wiltbank, Milo C.

doi:10.1016/j.theriogenology.2019.05.010

Cited by 23 publications

(23 citation statements)

References 39 publications

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“…-Following both procedures, induced additional corpora lutea [14,17] will reduce the risk of pregnancy loss [26].…”

Section: Discussionmentioning

confidence: 99%

“…Effectively, embryo transfer (ET) is considered the most effective mechanism for maximizing fertility during heat stress, improving fresh IVP embryo pregnancy results comparable to artificial insemination (AI) under heat stress conditions [12]. Treatment with GnRH on Day 5 post-estrus increases the corpus luteum (CL) blood flow area, thus improving luteal function assessed on Day 7 at ET [13] and prompting additional corpora lutea formation [14]. This treatment improves embryonic survival in IVP embryo recipients [14].…”

mentioning

confidence: 99%

“…Treatment with GnRH on Day 5 post-estrus increases the corpus luteum (CL) blood flow area, thus improving luteal function assessed on Day 7 at ET [13] and prompting additional corpora lutea formation [14]. This treatment improves embryonic survival in IVP embryo recipients [14].…”

mentioning

confidence: 99%

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Transfer of a single embryo versus drainage of subordinate follicles to prevent twin pregnancies in dairy cows. Why not both?

López‐Gatius

García-Ispierto

2020

Journal of Reproduction and Development

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In this study, we present two proposed approaches to prevent twin pregnancies in dairy cattle: 1) single, in vitro-produced embryonic transfer into a recipient cow or 2) subordinate follicle drainage at the time of insemination. Both procedures lead to improved embryonic survival. As the use of sexed semen generates herd replacements and additional heifers, we propose the transfer of a single female cattle embryo into cows that are not suitable for producing replacements, and follicular drainage in lactating cows with genetic merit. This should eliminate economic losses associated with twin pregnancies and increase cattle output of the herd.

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“…-Following both procedures, induced additional corpora lutea [14,17] will reduce the risk of pregnancy loss [26].…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Transfer of a single embryo versus drainage of subordinate follicles to prevent twin pregnancies in dairy cows. Why not both?

López‐Gatius

García-Ispierto

2020

Journal of Reproduction and Development

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“…Among the methods used include administration of progesterone via intravaginal devices and injection of gonadotropins or GnRH or its analogs. In some cases, positive effects on P/ET have been reported ( Vasconcelos et al, 2011b ; Wallace et al, 2011 ; Marques et al, 2012 ) whereas, in others, treatment was without effect ( Ellington et al, 1991 ; Purcell et al, 2005 ; Niles et al, 2019 ; Steichen and Larson, 2019 ; García-Guerra et al, 2020 ) or had a negative effect ( Monteiro et al, 2015 ).…”

Section: Some Ways Forwardmentioning

confidence: 99%

The incompletely fulfilled promise of embryo transfer in cattle—why aren’t pregnancy rates greater and what can we do about it?

Hansen

2020

Journal of Animal Science

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Typically, bovine embryos are transferred into recipient females about day 7 after estrus or anticipated ovulation, when the embryo has reached the blastocyst stage of development. All the biological and technical causes for failure of a female to produce a blastocyst 7 d after natural or artificial insemination (AI) are avoided when a blastocyst-stage embryo is transferred into the female. It is reasonable to expect, therefore, that pregnancy success would be higher for embryo transfer (ET) recipients than for inseminated females. This expectation is not usually met unless the recipient is exposed to heat stress or is classified as a repeat-breeder female. Rather, pregnancy success is generally similar for ET and AI. The implication is that either one or more of the technical aspects of ET have not yet been optimized or that underlying female fertility that causes an embryo to die before day 7 also causes it to die later in pregnancy. Improvements in pregnancy success after ET will depend upon making a better embryo, improving uterine receptivity, and forging new tools for production and transfer of embryos. Key to accelerating progress in improving pregnancy rates will be the identification of phenotypes or phenomes that allow the prediction of embryo competence for survival and maternal capacity to support embryonic development.

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“…At this time, high concentrations of estrogen aren't desirable since it can increase the possibility of luteolysis, which would interrupt the pregnancy (Marques et al, 2012). Due to the inconsistent results of the FTET and the controversial effectiveness of luteotropic hormones in increasing the pregnancy rate (Galvão et al, 2014;García-Guerra et al, 2020) The objectives of our study were to evaluate the effects of recipient category, season of the year, and administration of a GNRH analogue at the time of FTET on the conception rates at 30 (P/ET30) and 60 (P/ET60) days of gestation and on pregnancy losses.…”

Section: Introductionmentioning

confidence: 99%

Effect of Treatment With Gonadoreline at the Embryo Transfer on Pregnancy Outcomes in Bovine.

Defensor¹,

Faria²,

Marques³

et al. 2021

Preprint

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The aim of this study was to assess whether administration of the gonadotropin-releasing hormone (GnRH) agonist gonadorelin would increase conception rates at 30 (P / ET 30) and 60 (P / ET 60) days of gestation and reduce pregnancy losses (PL) in embryo recipients and what would be the correlation between the animal category and the season of the year in which the embryo transfer would occur. The experiment was conducted on 11 commercial farms in the state of Minas Gerais, Brazil. Recipients were randomly divided into groups: treated (n = 624), cows that received 0.1 mg gonadorelin on the day of FTET, and control (n = 687), untreated cows. All embryos were produced in vitro from oocyte donors of different races. Recipients were classified as heifers, dry cows or lactating cows. Higher conception rate was observed at 30 days (p = 0.03) and 60 days (p = 0.01) in the treated group (45.8%; 43.0%, respectively). Dry and lactating cows had less pregnancy loss (p = 0.001) compared to heifers (2.70% and 2.47% vs 10.42%, respectively). During spring/summer, there was less P/FTET at 30 days (0.024). Embryo transfer carried out in the warmer seasons of the year reduced the pregnancy rate to 60 days and increased pregnancy loss. As an implication, the use of the GnRH analogue can be used as a tool to increase fertility in embryo recipients.

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Postovulatory treatment with GnRH on day 5 reduces pregnancy loss in recipients receiving an in vitro produced expanded blastocyst

Cited by 23 publications

References 39 publications

Transfer of a single embryo versus drainage of subordinate follicles to prevent twin pregnancies in dairy cows. Why not both?

Transfer of a single embryo versus drainage of subordinate follicles to prevent twin pregnancies in dairy cows. Why not both?

The incompletely fulfilled promise of embryo transfer in cattle—why aren’t pregnancy rates greater and what can we do about it?

Effect of Treatment With Gonadoreline at the Embryo Transfer on Pregnancy Outcomes in Bovine.

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