Postoperative whole lung irradiation with or without adriamycin in osteogenic sarcoma

Zaharia, Mayer; Caceres, Eduardo; Valdivia, S.; Moran, Manuel R.; Tejada, Francisco

doi:10.1016/0360-3016(86)90384-6

Cited by 19 publications

(18 citation statements)

References 6 publications

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“…The studies were mainly conducted in Europe and USA. Five studies were randomized controlled trials (7,8,10,11,13), 3 were phase I/II studies (5,14,15), 3 were phase II trials (16)(17)(18) and 3 were retrospective series (19)(20)(21). Three studies (17,18,22) were considered at low risk of bias while 6 studies were considered at high to serious risk of bias (5,7,10,11,15,16).…”

Section: Resultsmentioning

confidence: 99%

Whole Lung Irradiation in Patients with Osteosarcoma and Ewing Sarcoma

et al. 2018

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Although the rate of severe toxicity was very low, the real impact of WLI on patients' outcomes remains unproven, probably due to the narrow dose limits that can be delivered to the whole lung parenchyma. New strategies to prevent or treat lung metastases in these patients should be tested. Ultra-fractionated radiotherapy concurrent with modern chemotherapy protocols could be tested in this setting due to the chemo-sensitizing effect and negligible radio-induced toxicity of fraction doses <0.5 Gy.

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Section: Resultsmentioning

confidence: 99%

Whole Lung Irradiation in Patients with Osteosarcoma and Ewing Sarcoma

et al. 2018

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“…While these studies (RAB et al 1976;ZAHARIA et al 1986;BURGERS et al 1988) as will as the recent prospective analysis at the University of Florida (ELLIS et al 1992) demonstrate that pulmonary irradiation can be delivered in the adjuvant setting with acceptable toxicity, the French Study (1988) did find clinically significant decrements in pulmonary function, perhaps because the radiation and chemotherapy were administered concomitantly. None of these studies demonstrates a statistically significant benefit to adjuvant pulmonary irradiation in terms of survival or disease-free survival (prevention of pulmonary metastases).…”

Section: Adjuvant Treatment: Radiation Therapymentioning

confidence: 99%

“…Certainly, in the clinical setting, gross disease in osteosarcoma requires a higher radiation dose for local control than does Wilms' tumor (GAITAN-YANGUAS 1981;. BARRETT 1978;BREUR and VAN DER SCHUEREN 1978;ZAHARIA et al 1986;BURGERS et al 1988;French Bone Tumor Study Group 1988). Given the dose limitation in bilateral whole lung irradiation, it is therefore of interest to explore the use of radiation as an adjuvant agent intended to prevent pulmonary metastatic disease (i.e., to treat presumptive micrometastatic disease).…”

Section: Adjuvant Treatment: Radiation Therapymentioning

confidence: 99%

“…"When the Okies left Oklahoma and moved to California, they raised the average intelligence level in both states." The Bogota group (ZAHARIA et al 1986) analyzed 36 patients given adjuvant therapy after definitive local surgery. The oldest of these studies, that of LOUGHEED et al (1965), analyzed 15 Gy prophylactic irradiation of one lung in conjunction with dactinomycin.…”

Section: Adjuvant Treatment: Radiation Therapymentioning

confidence: 99%

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Radiation Therapy in Pediatric Oncology

Cassady¹

1994

Medical Radiology

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The use of general descriptive names, registered, trademarks, etc. in this publications does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Typesetting: Thomson Press (India) Ltd., New Delhi SPIN: 1 0042321 21 13130/SPS -5 4 3 2 I 0 -printed on acid-free paper PrefaceThis book provides a thorough review of the role that radiation therapy currently plays in the management of most childhood tumors. Extensively augmented with figures and tables where appropriate, it also provides a concise review of current diagnostic and therapeutic approaches for major childhood malignancies. Extensive and up-to-date reference lists are an added benefit. Chapters on principles of pediatric radiation therapy, etiology of childhood tumors, and newer, molecular approaches in pediatric oncology are provided.Authors include leaders in the field writing on their particular areas of interest and expertise, providing a diversity of approach useful to the reader.Many people have been responsible for this book. Primary thanks must go to our many childhood patients and their parents who have allowed us the privilege of treating them. Appreciation and thanks are due to my many teachers and particular role models, HENRY

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“…In most cases, these series evaluate surgical metastasectomy independent of chemotherapy. Radiation therapy for pulmonary metastases has been disappointing [36,37].…”

Section: Introductionmentioning

confidence: 99%

Selected benefits of thoracotomy and chemotherapy for sarcoma metastatic to the lung

Mentzer

Antman

Attinger

et al. 1993

Journal of Surgical Oncology

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To determine the benefit of aggressive surgical therapy, we studied 77 consecutive patients presenting to our sarcoma registry with pulmonary metastases. Detailed follow-up was available on all patients; the median follow-up of the 13 long-term survivors was 72 months from the date of diagnosis of the primary tumor. Survival of these 77 patients with metastatic disease was independent of the size, location, and histology of the primary tumor. Once metastases developed, survival of patients with pulmonary metastases was not influenced by the extent of surgical resection of the primary tumor or by the use of radiation therapy. Pulmonary metastases were initially treated with thoracotomy and metastasectomy in 34 patients. The median survival after thoracotomy was 26 months. Seven patients were alive more than 4 years after their diagnosis. Pulmonary metastases were treated with chemotherapy alone in 43 patients. Although the survival was shorter (median survival 14 months) in patients treated with chemotherapy, an objective response to chemotherapy was obtained in 13 (30%) patients. Four of these patients were alive 4 years after their diagnosis. These data demonstrate that both thoracotomy and chemotherapy are associated with long-term survival of patients with sarcoma metastatic to the lung.

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Postoperative whole lung irradiation with or without adriamycin in osteogenic sarcoma

Cited by 19 publications

References 6 publications

Whole Lung Irradiation in Patients with Osteosarcoma and Ewing Sarcoma

Whole Lung Irradiation in Patients with Osteosarcoma and Ewing Sarcoma

Radiation Therapy in Pediatric Oncology

Selected benefits of thoracotomy and chemotherapy for sarcoma metastatic to the lung

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