Postoperative thyroid function and complications in relation to a measured thyroid remnant

Murley, R. S.; Rigg, Bruce M.

doi:10.1002/bjs.1800551011

Cited by 23 publications

(10 citation statements)

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“…After careful review of the histological material, especially in the patients who had become hypothyroid, we are not able to confirm the close correlation between lymphadenoid infiltration and subsequent hypothyroidism reported by Greene (1950). This is all the more interesting because one of us (R. S. M.) in a previous series at the Royal Northern Hospital had severe lymphadenoid change reported by Dr P. M. Peters in 50 per cent of the patients who developed postoperative hypothyroidism (Murley and Rigg, 1968). Dr Peters has kindly further assessed the material in our St Albans series and is in agreement with Dr Pugh's findings.…”

Section: Discussionmentioning

confidence: 64%

“…Evered et al (1973) showed an increasing T3 resin uptake (Thyopac-3) value as their classification of hypothyroid grades moves from subclinical to clinical. Murley and Rigg (1968) showed that the T3 values in their patients were all in the lower part of the normal range. (T, resin sponge uptake (Abbot Laboratories, Triosorb 125) as used by Murley and Rigg (1968) measured the residual lZ5I tri-iodothyronine on the resin sponge rather than the amount in the serum; …”

Section: Discussionmentioning

confidence: 95%

“…Murley and Rigg (1968) showed that the T3 values in their patients were all in the lower part of the normal range. (T, resin sponge uptake (Abbot Laboratories, Triosorb 125) as used by Murley and Rigg (1968) measured the residual lZ5I tri-iodothyronine on the resin sponge rather than the amount in the serum; …”

Section: Discussionmentioning

confidence: 95%

“…Taylor and Painter (1962) measured the volume in ml after application of a stent mould. Murley and Rigg (1968) recorded the 'cuboid' volume in ml. Michie et al (1972) and Young and Macleod (1972) estimated remnant size in g, and the latter authors suggested that as specific gravity measurements of thyroid tissue gave a mean of 1,081, records expressed in g are comparable to those in ml.…”

Section: Discussionmentioning

confidence: 99%

“…All the patients admitted under our care for partial thyroidectomy over the past 20 years have had recorded measurements of the resected specimen and thyroid remnants as described by Murley and Rigg (1968). The length, breadth and depth of the thyroid remnants are measured in cm and the result expressed as 'cuboid' volume in ml.…”

Section: Discussionmentioning

confidence: 99%

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Thyroid function following partial thyroidectomy

Griffiths

Murley

Gulin

et al. 1974

Journal of British Surgery

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The main objective of this investigation was to establish the incidence of hypothyroidism and recurrent goitre following partial thyroidectomy. Accurate measurements of the thyroid remnants and resected specimens have been made in all cases. The postoperative thyroid status has been assessed clinically and also biochemica!ly by serum fhyroxine as iodine, T, resin uptake, free thyroxine index and thyroid-stimulating hormone estimations. Serum calcium and phosphorus have also been measured and the necessary histological material reviewed.Postoperative hypothyroidism occurred in approximately I 1 per cent of previously toxic and 6.5 per cent of non-toxic patients, becoming evident in most cases within a year of operation. The T , resin uptake measurement follo wing operation in this and previous series suggests that in many patients there is a compensation process which is maintained by increased secretion of thyroid-stimulating hormone. N o evidence has been adduced that patients who show this compensation mechanism are, as some have suggested, in a state of 'subclinical hypothyroidism' or that they become overtly hypothyroid later.In this series hypothyroidism was more closely related to small remnant size than the presence of lymphadenoid change. A significantly higher proportion of patients with small thyroid remnants became hypothyroid in both toxic and non-toxic groups. Remnants of about 8-16 ml 'cuboid' volume (roughly 8-16 g by weight) have seemed reasonable for our patients.

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Section: Discussionmentioning

confidence: 64%