Postoperative survival of patients with potentially curable cancer of the colon

Abstract

The association between histopathologic findings and postoperative survival in 442 patients with potentially curable carcinomas of the colon has been analyzed using Cox's regression model. The prognostic variables included in the study were age, sex, stage of disease according to Dukes' classification and Broders' grading, as well as presence/absence at the time of operation of venous and nerve invasion. The overall five-year postoperative survival rate was 46.6 percent. Using a model including all prognostic factors, sex and Dukes' classification were not found to be associated with survival. Broders' grading and/or nerve invasion yielded only a borderline statistical significance in the model that included all factors. The invasion of veins was almost always associated with invasion of nerves.

Prognostic factors in colorectal cancer: Current status and new trends

“…So far, the relationship between tumor grading and prognosis is not fully understood: in our report as in others [ I ,2,4,7,15,21] no significant relation was observed, while grading was found as an independent variable conditioning the patient outcome in other series [3,8,9,16,20,22]. Moreover, it is not clearly known if the positive effect of abundant host lymphocytic reaction against tumor, resulting in a better patient outcome in multivariate analysis, is significant [7,21] or not [ 15, our data].…”

The role of perineural invasion in predicting survival in patients with primary operable colorectal cancer: A systematic review

“…Age, gender, TNM stage, venous invasion, tumour necrosis, peri-tumoural lymphocytic infiltration, tumour budding and CEA levels were also independently associated with poor survival in at least some studies [17,18,21,22,26,30,32,33,39].…”

Mesorectal Microfoci Adversely Affect the Prognosis of Patients With Rectal Cancer

“…[24][25][26]30,33,35,37 Only a few reports documented the prognostic impact of tumor perineural invasion. 25,40 More recently, in a specifically directed study on mesorectal foci, Reynolds et al 1 have assessed the incidence rates of vascular (26 percent), lymphatic (24 percent) and perineural (22 percent) deposits. In Ueno and Mochizuki's report, 10 four patterns were observed: scattering (5.1 percent), vessel invasion (15.7 percent), neural invasion (5.7 percent), and nodular (30.1 percent).…”

“…The endovascular (including endoarterial and endovenous) and endolymphatic routes are those most widely documented, [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] having been found as prognostic factors only in some studies. [24][25][26]30,33,35,37 Only a few reports documented the prognostic impact of tumor perineural invasion. 25,40 More recently, in a specifically directed study on mesorectal foci, Reynolds et al 1 have assessed the incidence rates of vascular (26 percent), lymphatic (24 percent) and perineural (22 percent) deposits.…”