Postoperative seizure and developmental outcomes of children with hemimegalencephaly and drug-resistant epilepsy

Liu, Qingzhu; Ma, Jiayi; Yu, Guojing; Zhang, Qian; Zhu, Ying; Wang, Ruofan; Yu, Hao; Liu, Chang; Sun, Yu; Wang, Wen; Wang, Shuang; Ji, Taoyun; Li, Ming; Liu, Xiaoyan; Jiang, Yuwu; Cai, Lixin; Wu, Ye

doi:10.1016/j.seizure.2021.08.006

Cited by 5 publications

(20 citation statements)

References 20 publications

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“…8 However, focal seizures were more common in patients with FCD type II and hemimegalencephaly. 21,22 (3) Developmental delay was common; approximately 3/4 of children had a moderate or severe delay in our cohort, while previous studies have reported this proportion as 16-49% in FCD type II and 92-97% in hemimegalencephaly. [21][22][23][24] (4) Epileptic encephalopathy was common.…”

Section: Discussionmentioning

confidence: 54%

“…21,22 (3) Developmental delay was common; approximately 3/4 of children had a moderate or severe delay in our cohort, while previous studies have reported this proportion as 16-49% in FCD type II and 92-97% in hemimegalencephaly. [21][22][23][24] (4) Epileptic encephalopathy was common. Approximately half of patients were diagnosed with WS during the disease course in our cohort.…”

Section: Discussionmentioning

confidence: 54%

“…19,20 In addition, MOGHE had a later onset age than hemimegalencephaly. 21 (2) Children with MOGHE usually had multiple seizure types, of which ES was the most common and was typically present as the initial manifestation; however, its appearance during the course of disease is common. We reported that nearly 4/5 of pediatric patients had ES, and 3/5 of children that experienced seizures began with ES.…”

Section: Discussionmentioning

confidence: 99%

“…Meanwhile, previous studies have reported the rate of epileptic encephalopathy as 32% in pediatric patients with FCD type II and 47% in patients with hemimegalencephaly. 21,25 (5) The interictal EEG pattern can…”

Section: Discussionmentioning

confidence: 99%

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Clinical characteristics and surgical outcomes in children with mild malformation of cortical development and oligodendroglial hyperplasia in epilepsy

et al. 2023

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ObjectiveMild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) is a new and rare histopathological entity of cortical developmental malformations. The clinical characteristics of MOGHE remain challenging.MethodsChildren with histologically confirmed MOGHE were retrospectively studied. The clinical findings, electroclinical and imaging features, and postoperative outcomes were analyzed, and previously published studies were reviewed up to June 2022.ResultsThirty‐seven children were included in our cohort. Clinical characteristics included early onset in infancy (94.6% before 3 years), multiple seizure types, and moderate or severe delay. Epileptic spasm is the most common seizure type and initial manifestation. The lesions were mainly multilobar (59.5% multiple lobes and 8.1% hemispheres), and predominance in the frontal lobe was observed. The interictal EEG pattern was circumscribed or widespread. The prominent MRI characteristics were cortical thickening, cortical/subcortical hyperintense T2/FLAIR signal, and blurring at the GM and WM transition. Among the 21 children followed up for more than 1 year after surgery, 76.2% were seizure‐free. Preoperative interictal circumscribed discharges and larger resections were significantly associated with a good postoperative outcome. The clinical features of 113 patients in the reviewed studies were similar to those we reported, but the lesions were mainly unilobar (73.5%) and Engel I was achieved in only 54.2% after surgery.SignificanceDistinct clinical characteristics in MOGHE, especially age at onset, epileptic spasm, and age‐related MRI characteristics, can help in early diagnosis. Preoperative interictal discharge and surgical strategy may be predictors of postoperative outcomes.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clinical characteristics and surgical outcomes in children with mild malformation of cortical development and oligodendroglial hyperplasia in epilepsy

et al. 2023

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“…When drugs fail to control seizures, a surgical option is recommended for good surgical candidates who manifest focal findings on long-term video EEG and neuroimaging. Surgical treatment initiated early in the disease course may significantly improve both seizure and developmental outcomes [9,10]; a series of studies have shown that a seizure-free outcome is obtained in approximately 60-83% of children with intractable epileptic spasms [10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Resective epilepsy surgery for West syndrome: The Hypsarrhythmic Asymmetric Scoring Scheme is a determining predictor of seizure outcome

Li¹,

Lin²,

Tan³

et al. 2022

Seizure: European Journal of Epilepsy

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Seizure outcomes in children with Sturge-Weber syndrome undergoing epilepsy surgery: An individual participant data meta-analysis

Mozaffari

Krishnakumar

Chen

et al. 2023

Seizure: European Journal of Epilepsy

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Postoperative seizure and developmental outcomes of children with hemimegalencephaly and drug-resistant epilepsy

Cited by 5 publications

References 20 publications

Clinical characteristics and surgical outcomes in children with mild malformation of cortical development and oligodendroglial hyperplasia in epilepsy

Clinical characteristics and surgical outcomes in children with mild malformation of cortical development and oligodendroglial hyperplasia in epilepsy

Resective epilepsy surgery for West syndrome: The Hypsarrhythmic Asymmetric Scoring Scheme is a determining predictor of seizure outcome

Seizure outcomes in children with Sturge-Weber syndrome undergoing epilepsy surgery: An individual participant data meta-analysis

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