Postoperative Schmerztherapie

Zucker, T.-P.

doi:10.1007/s001290050196

Cited by 3 publications

(1 citation statement)

References 13 publications

(24 reference statements)

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“…Combination of dipyrone with another drug Tulunay 1996 No usable data - first dose data contaminated; used nonstandard PI scale. Drugs were not identical in appearance Velez Rivera 1997 Not randomised or blind. Vergara 1998 No data to extract. Villareal Guzman 1993 Small size (n = 8). Weber 1971 Not randomised. Wieck 1970 Combination of dipyrone with another drug. Wolff 1971 Not randomised. Zieren 1999 No data to extract. Zucker 1997 Not a randomised controlled trial - review. Zuev 1997 Not randomised or blind. PCA=Patient controlled anaesthesia …”

Section: Characteristics Of Included Studies [Ordered By Study Id]mentioning

confidence: 99%

Single dose dipyrone for acute postoperative pain

Derry

Faura²,

Edwards

et al. 2010

Cochrane Database of Systematic Reviews

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Background Dipyrone (metamizole) is a non-steroidal anti-inflammatory drug used in some countries to treat pain (postoperative, colic, cancer, and migraine); it is banned in others because of an association with life-threatening blood agranulocytosis. This review updates a 2001 Cochrane review, and no relevant new studies were identified, but additional outcomes were sought. Objectives To assess the efficacy and adverse events of single dose dipyrone in acute postoperative pain. Search methods The earlier review searched CENTRAL, MEDLINE, EMBASE, LILACS and the Oxford Pain Relief Database to December 1999. For the update we searched CENTRAL, MEDLINE,EMBASE and LILACS to February 2010. Selection criteria Single dose, randomised, double-blind, placebo or active controlled trials of dipyrone for relief of established moderate to severe postoperative pain in adults. We included oral, rectal, intramuscular or intravenous administration of study drugs. Data collection and analysis Studies were assessed for methodological quality and data extracted by two review authors independently. Summed total pain relief over six hours (TOTPAR) was used to calculate the number of participants achieving at least 50% pain relief. Derived results were used to calculate, with 95% confidence intervals, relative benefit compared to placebo, and the number needed to treat (NNT) for one participant to experience at least 50% pain relief over six hours. Use and time to use of rescue medication were additional measures of efficacy. Information on adverse events and withdrawals was collected. Main results Fifteen studies tested mainly 500 mg oral dipyrone (173 participants), 2.5 g intravenous dipyrone (101), 2.5 g intramuscular dipyrone (99); fewer than 60 participants received any other dose. All studies used active controls (ibuprofen, paracetamol, aspirin, flurbiprofen, ketoprofen, dexketoprofen, ketorolac, pethidine, tramadol, suprofen); eight used placebo controls. Over 70% of participants experienced at least 50% pain relief over 4 to 6 hours with oral dipyrone 500 mg compared to 30% with placebo in five studies (288 participants; NNT 2.4 (1.9 to 3.2)). Fewer participants needed rescue medication with dipyrone (7%) than with placebo (34%; four studies, 248 participants). There was no difference in participants experiencing at least 50% pain relief with 2.5 g intravenous dipyrone and 100 mg intravenous tramadol (70% vs 65%; two studies, 200 participants). No serious adverse events were reported. Authors’ conclusions Based on very limited information, single dose dipyrone 500 mg provides good pain relief to 70% of patients. For every five individuals given dipyrone 500 mg, two would experience this level of pain relief who would not have done with placebo, and fewer would need rescue medication, over 4 to 6 hours.

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Section: Characteristics Of Included Studies [Ordered By Study Id]mentioning

confidence: 99%

Single dose dipyrone for acute postoperative pain

Derry

Faura²,

Edwards

et al. 2010

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

show abstract

Single dose dipyrone for acute postoperative pain

Derry

Faura

Edwards

et al. 2001

The Cochrane Database of Systematic Reviews (Protocol)

View full text Add to dashboard Cite

Background-Dipyrone (metamizole) is a non-steroidal anti-inflammatory drug used in some countries to treat pain (postoperative, colic, cancer, and migraine); it is banned in others because of an association with life-threatening blood agranulocytosis. This review updates a 2001 Cochrane review, and no relevant new studies were identified, but additional outcomes were sought. Objectives-To assess the efficacy and adverse events of single dose dipyrone in acute postoperative pain. Search methods-The earlier review searched CENTRAL, MEDLINE, EMBASE, LILACS and the Oxford Pain Relief Database to December 1999. For the update we searched CENTRAL, MEDLINE,EMBASE and LILACS to February 2010. Selection criteria-Single dose, randomised, double-blind, placebo or active controlled trials of dipyrone for relief of established moderate to severe postoperative pain in adults. We included oral, rectal, intramuscular or intravenous administration of study drugs. Data collection and analysis-Studies were assessed for methodological quality and data extracted by two review authors independently. Summed total pain relief over six hours

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